Telomere Length Correlates with Life Span of Dog Breeds

Fick, Laura J.; Fick, Gordon H.; Li, Zi‐Chen; Cao, Eric; Bao, Bo; Heffelfinger, Doug; Parker, Heidi G.; Ostrander, Elaine A.; Riabowol, Karl

doi:10.1016/j.celrep.2012.11.021

“…A shortening of telomeres with cell replications of in vitro canine fibroblasts has been detected [22] , and Fick et al [21] showed a connection between telomere loss with age in 15 dog breeds (n=175), similar to our results. Furthermore, Fick et al [21] reported that different dog breeds varied in telomere length, which contributed to average lifespan. Moreover, dog breeds with shorter telomeres exhibited higher susceptibility to cardiovascular, gastrointestinal, musculoskeletal and respiratory disorders.…”

Section: Discussionsupporting

confidence: 81%

“…Telomere length shortening occurs normally in somatic cells during DNA replication [13] , throughout the life of an individual [14][15][16][17][18][19][20] . Thus, measures of telomere length have been used to estimate age in several mammalian species, including mice [19] , dogs [15,21,22] , sea lions [20] and humans [18,23] . However, results have been inconsistent; correlations between telomere length and age have been found in some [14,16] , but not all studies [15] .…”

Section: Introductionmentioning

confidence: 99%

Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Buddhachat¹,

KRIANGWANICH²,

KUMOUN³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This Article AbstractHere, we explored the rate of telomere attrition with increasing age by real-time quantitative PCR (qPCR) in a short-(Chihuahua dog) and long-(Asian elephant) lived species. A total of 122 Asian elephants (female = 106, male = 16) ranging from 24-840 months of age, and 89 Chihuahuas (female = 65, male = 24) 1-179 months of age were used in this study. We found that young (pre-and peri-pubertal) Asian elephants had a higher relative telomere length (RTL) compared to dogs. A low, but significant negative relationship between RTL and increasing age was observed in both Chihuahuas (R 2 =0.0490, P=0.0017) and Asian elephants (R 2 =0.0177, P=0.0210). The estimated rate of telomere loss for males and females of both species ranged from -0.0023 to -0.0065, with no clear differences between gender or species. Results suggest that Asian elephants may start with longer telomeres than Chihuahuas, as RTL was higher, but then the rate of telomere attrition proceeds at a similar rate in both species. Age accounted for only a small percentage of the variation in RTL in both Chihuahua dogs and Asian elephants, however. Thus, its use as a biological tool for age estimation would appear to be limited for these species. Keywords: Age, Asian elephant, Dog, Telomere Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma ÖzetBu çalışmada, kısa (Chihuahua köpek) ve uzun (Asya fili) ömürlü hayvanlarda artan yaş ile birlikte telomerik yıpranma oranı gerçek zamanlı kantitatif PCR (qPCR) kullanılarak araştırıldı. Yaşları 24-840 hafta arasında değişen toplam 122 Asya fili (106 dişi ve 16 erkek) ile 1-179 aylık Chihuahua (65 dişi ve 24 erkek) çalışmada kullanıldı. Genç Asya filleri (pre-ve peri-puberte) köpekler ile karşılaştırıldığında daha fazla orantısal telomer uzunluğuna sahip olduğu tespit edildi. Hem Chihuahua (R 2 =0.0490, P=0.0017) hem de Asya fillerinde (R 2 =0.0177, P=0.0210) orantısal telomer uzunluğu ile artan yaş arasında düşük ama anlamlı negatif yönlü bir ilişki gözlemlendi. Her iki tür için erkek ve dişi hayvanlardaki tahmini telomer kayıp oranı 0.0023 ile 0.0065 arasında değişirken tür veya cinsiyet yönünden bir fark tespit edilmedi. Elde edilen sonuçlar daha fazla orantısal telomer uzunluğuna sahip olan Asya fillerinin Chihuahua köpeklerden daha uzun telomer ile başladıklarını ancak daha sonra telomer yıpranmanın her iki türde de benzer oranda şekillendiğini gösterdi. Hem Chihuahua köpeklerde hem de Asya fillerinde orantısal telomer uzunluğundaki varyasyonun sadece küçük bir yüzdesi yaşa bağlıdır. Bu sebeple, yaş tayininde bir biyolojik araç olarak kullanılması bu türlerde sınırlı gözükmektedir.

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“…By contrast, we did find a significant negative correlation between age and telomere length in Chihuahua dogs (n=89). A shortening of telomeres with cell replications of in vitro canine fibroblasts has been detected [22] , and Fick et al [21] showed a connection between telomere loss with age in 15 dog breeds (n=175), similar to our results. Furthermore, Fick et al [21] reported that different dog breeds varied in telomere length, which contributed to average lifespan.…”

Section: Discussionsupporting

confidence: 81%

“…By contrast, in Chihuahua dogs, we found a significant correlation between RTL and age in females. This result contrasts with that of Fick et al [21] though, who found a relationship in male, but not female dogs. That study did not consider breed in data analyses, so differential results might be due to a species difference.…”

Section: Dog and Elephant Telomeres With Age Changecontrasting

confidence: 56%

Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Buddhachat¹,

Kriangwanich²,

Kumoun³

et al. 2017

Kafkas Univ Vet Fak Derg

0

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Citation of This Article AbstractHere, we explored the rate of telomere attrition with increasing age by real-time quantitative PCR (qPCR) in a short-(Chihuahua dog) and long-(Asian elephant) lived species. A total of 122 Asian elephants (female = 106, male = 16) ranging from 24-840 months of age, and 89 Chihuahuas (female = 65, male = 24) 1-179 months of age were used in this study. We found that young (pre-and peri-pubertal) Asian elephants had a higher relative telomere length (RTL) compared to dogs. A low, but significant negative relationship between RTL and increasing age was observed in both Chihuahuas (R 2 =0.0490, P=0.0017) and Asian elephants (R 2 =0.0177, P=0.0210). The estimated rate of telomere loss for males and females of both species ranged from -0.0023 to -0.0065, with no clear differences between gender or species. Results suggest that Asian elephants may start with longer telomeres than Chihuahuas, as RTL was higher, but then the rate of telomere attrition proceeds at a similar rate in both species. Age accounted for only a small percentage of the variation in RTL in both Chihuahua dogs and Asian elephants, however. Thus, its use as a biological tool for age estimation would appear to be limited for these species. Keywords: Age, Asian elephant, Dog, Telomere Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma ÖzetBu çalışmada, kısa (Chihuahua köpek) ve uzun (Asya fili) ömürlü hayvanlarda artan yaş ile birlikte telomerik yıpranma oranı gerçek zamanlı kantitatif PCR (qPCR) kullanılarak araştırıldı. Yaşları 24-840 hafta arasında değişen toplam 122 Asya fili (106 dişi ve 16 erkek) ile 1-179 aylık Chihuahua (65 dişi ve 24 erkek) çalışmada kullanıldı. Genç Asya filleri (pre-ve peri-puberte) köpekler ile karşılaştırıldığında daha fazla orantısal telomer uzunluğuna sahip olduğu tespit edildi. Hem Chihuahua (R 2 =0.0490, P=0.0017) hem de Asya fillerinde (R 2 =0.0177, P=0.0210) orantısal telomer uzunluğu ile artan yaş arasında düşük ama anlamlı negatif yönlü bir ilişki gözlemlendi. Her iki tür için erkek ve dişi hayvanlardaki tahmini telomer kayıp oranı 0.0023 ile 0.0065 arasında değişirken tür veya cinsiyet yönünden bir fark tespit edilmedi. Elde edilen sonuçlar daha fazla orantısal telomer uzunluğuna sahip olan Asya fillerinin Chihuahua köpeklerden daha uzun telomer ile başladıklarını ancak daha sonra telomer yıpranmanın her iki türde de benzer oranda şekillendiğini gösterdi. Hem Chihuahua köpeklerde hem de Asya fillerinde orantısal telomer uzunluğundaki varyasyonun sadece küçük bir yüzdesi yaşa bağlıdır. Bu sebeple, yaş tayininde bir biyolojik araç olarak kullanılması bu türlerde sınırlı gözükmektedir.

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“…This could be the case in dogs, where lifespan is negatively correlated with body size among breeds and telomere length in larger dog breeds is reported to be shorter than in the smaller breeds. However, the extreme variation in size created in this species (100 fold) could have created aberrant patterns that are not evident under natural conditions [26]. A key question then is whether telomere length covaries with intraspecific variation in body size in natural conditions, in the absence of such extreme size variation.…”

Section: Introductionmentioning

confidence: 99%

On being the right size: increased body size is associated with reduced telomere length under natural conditions

Ringsby

¹

,

Jensen

²

,

Pärn

³

et al. 2015

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Evolution of body size is likely to involve trade-offs between body size, growth rate and longevity. Within species, larger body size is associated with faster growth and ageing, and reduced longevity, but the cellular processes driving these relationships are poorly understood. One mechanism that might play a key role in determining optimal body size is the relationship between body size and telomere dynamics. However, we know little about how telomere length is affected when selection for larger size is imposed in natural populations. We report here on the relationship between structural body size and telomere length in wild house sparrows at the beginning and end of a selection regime for larger parent size that was imposed for 4 years in an isolated population of house sparrows. A negative relationship between fledgling size and telomere length was present at the start of the selection; this was extended when fledgling size increased under the selection regime, demonstrating a persistent covariance between structural size and telomere length. Changes in telomere dynamics, either as a correlated trait or a consequence of larger size, could reduce potential longevity and the consequent trade-offs could thereby play an important role in the evolution of optimal body size.

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Telomere Length Correlates with Life Span of Dog Breeds

Cited by 66 publications

References 40 publications

Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

On being the right size: increased body size is associated with reduced telomere length under natural conditions

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