Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Buddhachat, Kittisak; KRIANGWANICH, Wannapimol; KUMOUN, Isaraporn; BROWN, Janine L.; CHAILANGKARN, Sasisophin; SOMGIRD, Chaleamchat; THITARAM, Chatchote; Prasitwattanaseree, Sukon; NGANVONGPANIT, Korakot

doi:10.9775/kvfd.2017.17504

Cited by 3 publications

(2 citation statements)

References 19 publications

(38 reference statements)

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“…(i.4) Elephants (order Proboscidea, suborder Elephantiformes). Telomere length has been studied in relation to age in the Asian elephant using 122 samples across the full lifespan of the species (Buddhachat et al, 2017). A significant decline in telomere length was found (P < 0.05) independent of any observed effect for sex-linked differences in ageing rate.…”

Section: Speciesmentioning

confidence: 99%

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

et al. 2023

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Various biological attributes associated with individual fitness in animals change predictably over the lifespan of an organism. Therefore, the study of animal ecology and the work of conservationists frequently relies upon the ability to assign animals to functionally relevant age classes to model population fitness. Several approaches have been applied to determining individual age and, while these methods have proved useful, they are not without limitations and often lack standardisation or are only applicable to specific species. For these reasons, scientists have explored the potential use of biological clocks towards creating a universal age‐determination method. Two biological clocks, tooth layer annulation and otolith layering have found universal appeal. Both methods are highly invasive and most appropriate for post‐mortem age‐at‐death estimation. More recently, attributes of cellular ageing previously explored in humans have been adapted to studying ageing in animals for the use of less‐invasive molecular methods for determining age. Here, we review two such methods, assessment of methylation and telomere length, describing (i) what they are, (ii) how they change with age, and providing (iii) a summary and meta‐analysis of studies that have explored their utility in animal age determination. We found that both attributes have been studied across multiple vertebrate classes, however, telomere studies were used before methylation studies and telomere length has been modelled in nearly twice as many studies. Telomere length studies included in the review often related changes to stress responses and illustrated that telomere length is sensitive to environmental and social stressors and, in the absence of repair mechanisms such as telomerase or alternative lengthening modes, lacks the ability to recover. Methylation studies, however, while also detecting sensitivity to stressors and toxins, illustrated the ability to recover from such stresses after a period of accelerated ageing, likely due to constitutive expression or reactivation of repair enzymes such as DNA methyl transferases. We also found that both studied attributes have parentally heritable features, but the mode of inheritance differs among taxa and may relate to heterogamy. Our meta‐analysis included more than 40 species in common for methylation and telomere length, although both analyses included at least 60 age‐estimation models. We found that methylation outperforms telomere length in terms of predictive power evidenced from effect sizes (more than double that observed for telomeres) and smaller prediction intervals. Both methods produced age correlation models using similar sample sizes and were able to classify individuals into young, middle, or old age classes with high accuracy. Our review and meta‐analysis illustrate that both methods are well suited to studying age in animals and do not suffer significantly from variation due to differences in the lifespan of the species, genome size, karyotype, or tissue type but rather that quantitative method, patterns of inheritance, and environmental factors should be the main considerations. Thus, provided that complex factors affecting the measured trait can be accounted for, both methylation and telomere length are promising targets to develop as biomarkers for age determination in animals.

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Section: Speciesmentioning

confidence: 99%

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

et al. 2023

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“…They play an important role in maintaining chromosome integrity which may be affected by deterioration or damage (Blackburn, 1991;Shay and Wright, 2000;Takasaki et al, 2003) Telomere length shortening occurs normally in most somatic cells during DNA replication throughout the lifespan of living organisms (McEachern et al, 2000;Cawthon, 2002;McKevitt et al, 2002;Haussmann et al, 2003;Vleck et al, 2003;Callicott and Womack, 2006;Hewakapuge et al, 2008;Izzo et al, 2011). Presently, telomere length has been widely used to estimate age in human subjects (Hewakapuge et al, 2008;Karlsson et al, 2008) and for several other mammalian species such as mice (Callicott andWomack, 2006), dogs (Nasir et al, 2001;McKevitt et al, 2002;Fick et al, 2012;Buddhachat et al, 2017), sea lions (Izzo et al, 2011) and elephants (Buddhachat et al, 2017). However, when the outcomes from several studies were compared, a degree of inconsistency was observed among the various subjects.…”

Section: Introductionmentioning

confidence: 99%

Age Estimation by Telomeric Length Using Human (Homo sapiens) and Domestic Cat (Felis catus) Epidermis, Bone and Cartilage Samples was Found to be Ineffective

Kaewkool¹,

Kriangwanich²,

Buddhachat³

et al. 2020

CMUJNS

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Age estimation using telomere length is an alternative tool that could facilitate the casework in forensic investigations. Although blood can be used in the measurement of telomere length in order to estimate chronological age and/or biological age, the use of blood does present certain potential limitations such as the possibility of infection, the influence of medication, chemicals or the level of stress a subject might have been exposed to, all of which can

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Decline in telomere length with increasing age across nonhuman vertebrates: A meta‐analysis

et al. 2021

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The prediction that telomere length (TL) shortens with increasing age is a major element in considering the role of telomeres as a key player in evolution. While telomere attrition is found in humans both in vitro and in vivo, the increasing number of studies reporting diverse age-specific patterns of TL challenges the hypothesis of a universal decline of TL with increasing age. Here we performed a meta-analysis to estimate the relationship between TL and age across 175 estimates encompassing 98 species of vertebrates. We found that, on average, TL does decline with increasing age during adulthood. However, this decline was weak and variable across vertebrate classes, and we also found evidence for a publication bias that might weaken our current evidence of decreasing TL with increasing age. We found no evidence for a faster decline in TL with increasing age when considering the juvenile stage (from birth to age at first reproduction) compared to the adult stage. Heterogeneity in TL ageing rates was explained by the method used to measure telomeres: detectable TL declines with increasing age were found only among studies using TRF with in-gel hybridisation and qFISH methods, but not in studies using qPCR and Southern blot-based TRF methods. While we confirmed that TL declines with increasing age in most adult vertebrates, our results identify an influence of telomere measurement methodology, which highlights the need to examine more thoroughly the effect of the method of measurement on TL estimates.

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Kısa (Chihuahua köpek) ve Uzun (Asya fili) Ömürlü Hayvanlarda Artan Yaş İle Birlikte Telomerik Yıpranma

Cited by 3 publications

References 19 publications

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

Age Estimation by Telomeric Length Using Human (Homo sapiens) and Domestic Cat (Felis catus) Epidermis, Bone and Cartilage Samples was Found to be Ineffective

Decline in telomere length with increasing age across nonhuman vertebrates: A meta‐analysis

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