2016
DOI: 10.18632/aging.100873
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Abstract: Telomere shortening occurs when cells divide, both in vitro and in vivo. On the other hand, telomerase is able to maintain telomere length in cells by adding TTAGGG repeats to the ends of telomeres. However, the interrelationships existing among telomere length, telomerase activity and growth in vertebrates remain to be clarified. In the present study we measured telomere length (terminal restriction fragment length), telomerase activity and body growth of Oryzias latipes from the embryo stage until senescence… Show more

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Cited by 32 publications
(121 citation statements)
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References 67 publications
(121 reference statements)
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“…To our knowledge, late-growth elongation, like we observed, is only known for one species, the fish Oryzias latipes [54]. Increased telomerase activity is the proposed mechanism for developmental telomere elongation observed in O. latipes [54], so this is likely the same mechanism contributing to our results. Although we did not measure telomerase directly, we measured an increase in telomere length from shortest length on day 15 back to hatch day length by day 30, similar to what was shown in O. latipes .…”
Section: Discussionsupporting
confidence: 67%
“…To our knowledge, late-growth elongation, like we observed, is only known for one species, the fish Oryzias latipes [54]. Increased telomerase activity is the proposed mechanism for developmental telomere elongation observed in O. latipes [54], so this is likely the same mechanism contributing to our results. Although we did not measure telomerase directly, we measured an increase in telomere length from shortest length on day 15 back to hatch day length by day 30, similar to what was shown in O. latipes .…”
Section: Discussionsupporting
confidence: 67%
“…Previous studies have shown that heat stress reduced telomere length in the Siberian sturgeon Acipenser baerii (Simide, Angelier, Gaillard, & Stier, 2016) and the brown trout Salmo trutta (Debes et al, 2016). Fishes show life stage-specific telomere lengths because they exhibit lifelong somatic growth and express telomerase across tissues and throughout all life stages (Anchelin, Murcia, Alcaraz-Pérez, García-Navarro, & Cayuela, 2011;Hartmann et al, 2009;Hatakeyama et al, 2016). Fishes show life stage-specific telomere lengths because they exhibit lifelong somatic growth and express telomerase across tissues and throughout all life stages (Anchelin, Murcia, Alcaraz-Pérez, García-Navarro, & Cayuela, 2011;Hartmann et al, 2009;Hatakeyama et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…One possible mechanism could relate to telomerase expression, which is capable of elongating telomeres (Blackburn, ). Many species downregulate telomerase expression in postembryonic somatic tissue; however, a number of fish studies have found telomerase to be active in a diversity of somatic cells at various postembryonic life stages (Hartmann et al., ; Hatakeyama et al., ; Lund, Glass, Tolar, & Blazar, ; Yip et al., ). Moreover, studies suggest that telomerase activity is positively linked to fish growth rate (Hatakeyama et al., ; Peterson, Mok, & Au, ; Yap, Yeoh, Brenner, & Venkatesh, ).…”
Section: Discussionmentioning
confidence: 99%
“…Many species downregulate telomerase expression in postembryonic somatic tissue; however, a number of fish studies have found telomerase to be active in a diversity of somatic cells at various postembryonic life stages (Hartmann et al, 2009;Hatakeyama et al, 2016;Lund, Glass, Tolar, & Blazar, 2009;Yip et al, 2017). Moreover, studies suggest that telomerase activity is positively linked to fish growth rate (Hatakeyama et al, 2016;Peterson, Mok, & Au, 2015;Yap, Yeoh, Brenner, & Venkatesh, 2005). Therefore, it is possible that fathers who have a slower growth rate in early life also experience a down-regulation in telomerase expression, which could affect germline telomere length and therefore the telomere length of their offspring.…”
Section: Embryo Rtl (Log) Adjusted Fry Rtl (Log)mentioning
confidence: 99%