Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome

Lu, Lingeng; Zhang, Chong; Zhu, Guanbao; Irwin, Melinda L.; Risch, Harvey A.; Menato, Guido; Mitidieri, Marco; Katsaros, Dionyssios; Yu, Herbert

doi:10.1186/bcr2893

Cited by 69 publications

(51 citation statements)

References 49 publications

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“…The detection of increased telomerase activity and shortening of telomeres are hypothesized to serve as specific signals of carcinogenesis. According to a number of studies (25)(26)(27), the detection of telomerase activity or telomere length alterations may be observed either in migrating cancer cells or in peripheral blood leukocytes. Such results may provide an opportunity to distinguish or qualify patients with differential cancer stages or grades.…”

Section: Discussionmentioning

confidence: 99%

Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer

et al. 2016

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Abstract.Telomere shortening is associated with cancer development, primarily through the induction of genomic instability. The majority of studies have indicated that individuals with shorter blood telomeres may be at a higher risk of developing various types of cancer. There is increasing evidence that the study of the alterations in telomere length may improve cancer prognosis. The aim of the present study was to verify the use of telomere length parameters in the diagnostics of breast cancer stage. Telomere length was analyzed in the blood leukocytes of 52 patients with breast cancer relative to 47 control subjects using quantitative polymerase chain reaction. The effects of stage, grade, estrogen receptor, progesterone receptor and human epidermal growth factor 2 (HER2) status were assessed. The current study demonstrated that the average telomeric sequence length was significantly shorter in leukocytes from individuals diagnosed with a more severe stage of breast cancer (T2N1M0) than in leukocytes in the early stages of the disease (T1N0M0) (P=0.0207). Furthermore, the data indicated that telomeres in leukocytes derived from patients with HER2 + breast cancer were significantly longer compared with those with the HER2 -type (P=0.0347). These results suggest that the assessment of telomeres in blood leukocytes may, at least partially, correspond with breast cancer staging and HER2 receptor status.

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Section: Discussionmentioning

confidence: 99%

Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer

et al. 2016

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“…It is critical to explore molecular biomarkers to guide clinical decision-making with regard to the treatment of GC. TA is thought to be a critical step in the evolution of most tumor types (34)(35)(36)(37), including GC (38,39). Considerable clinical research has been conducted with the aim of assessing the correlation between TA expression and clinicopathological outcome in patients with GC, but the Size Histo T N M TNM >5 cm P/U T3/T4 positive/ positive/ TIII/IV (<5 cm) (W/M) (T1/T2) (negative) (negative) (TI/TII) Liu et al (27) 2008 English China 26 (14) --20 (6) 22 (4) 11 (15) 24 (2) Yang et al (15) 2001 English China 40 (2) 26 (14) 30 (10) 26 (14) 20 (20) -17 (23) Wu et al (17) 2006 English China 52 (12) 23 (29) 49 (3) 40 (12) 37 (15) 14 (38) 33 (19) Hu et al (23) 2004 English China 18 (17) 10 (8) 14 (4) 7 (11) 14 (4) 10 (8) -Zhan et al (31) 1999 English China 81 (13) 46 (35) 43 (38) 68 (13) 51 (30) -60 (21) Hu et al (16) 2009 English China 41 (5) 28 (13) 33 (8) 21 (20) 5 (36) 30 (11) -Wang et al (18) 2004 English China 32 (9) 19 (13) 25 (7) (21) 43 (1) 18 …”

Section: Discussionmentioning

confidence: 99%

Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Lü

Deng²,

Cao

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Activation of telomerase is involved in carcinogenesis in most types of cancers. However, the prognostic value of telomerase activity (TA) in patients with gastric carcinoma (GC) remains controversial. We conducted a meta-analysis to assess the relationship between TA and the clinical outcome of GC. A meta-analysis of 18 studies (886 patients) was performed to evaluate the association between TA and metastasis-related parameters in GC patients by searching databases, including PubMed, MEDLINE, EMBASE, Web of Science databases, Cochrane Library and the Chinese Biomedical Literature database (CBM) (last search updated in October 2011). We used the odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association between TA and metastasis of GC. Our analysis results indicated that high telomerase activity expression tended to be associated with the presence of lymph node metastasis (866 patients) (OR=2.03, 95% CI 1.21-3.39, p=0.007), the depth of invasion (886 patients) (OR=1.87, 95% CI 1.30-2.70, p=0.0007), distant metastasis (407 patients) (OR=2.71, 95% CI 1.59-4.63, p=0.0002), tumor size (466 patients) (OR=2.14, 95% CI 1.31-3.50, p=0.002) and TNM stage (711 patients) (OR=2.39, 95% CI 1.30-4.41, p=0.005). However, high TA expression was not associated with the presence of histologic differentiation (791 patients) (OR=1.51, 95% CI 0.73-3.11, p=0.26). In conclusion, telomerase overexpression not only plays a key role in primary initiation, but also promotes invasion and metastatic progression of GC.These findings raise the possibility of using TA to screen for the prognosis of gastric cancer.

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“…disease or survival outcomes, 13 whereas other studies have shown that TL was related to breast cancer risk 46,51 and survival. 10,46,47 Although interpretation remains difficult, the results of the current study nonetheless provide provocative new data that suggest it is possible to influence TL in cancer survivors through the use of psychosocial interventions involving group support, emotional expression, stress reduction, and mindfulness meditation.…”

mentioning

confidence: 95%

“…[10][11][12] However, the relationships between TL and the clinical or pathological features of tumors are still not clearly understood. 13 Recent emerging research has suggested that TL and its enzyme telomerase may be susceptible to psychosocial influences, particularly stress. 14 Telomerase is the specialized cellular reverse transcriptase that elongates telomeric DNA, thereby counteracting the telomere shortening that occurs with successive rounds of cell division.…”

Section: Introductionmentioning

confidence: 99%

Mindfulness‐based cancer recovery and supportive‐expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors

Carlson

Beattie

Giese‐Davis

et al. 2014

Cancer

140

109

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BACKGROUND: Group psychosocial interventions including mindfulness-based cancer recovery (MBCR) and supportive-expressive group therapy (SET) can help breast cancer survivors decrease distress and influence cortisol levels. Although telomere length (TL) has been associated with breast cancer prognosis, the impact of these two interventions on TL has not been studied to date. METHODS: The objective of the current study was to compare the effects of MBCR and SET with a minimal intervention control condition (a 1-day stress management seminar) on TL in distressed breast cancer survivors in a randomized controlled trial. MBCR focused on training in mindfulness meditation and gentle Hatha yoga whereas SET focused on emotional expression and group support. The primary outcome measure was relative TL, the telomere/single-copy gene ratio, assessed before and after each intervention. Secondary outcomes were self-reported mood and stress symptoms. RESULTS: Eighty-eight distressed breast cancer survivors with a diagnosis of stage I to III cancer (using the American Joint Committee on Cancer (AJCC) TNM staging system) who had completed treatment at least 3 months prior participated. Using analyses of covariance on a per-protocol sample, there were no differences noted between the MBCR and SET groups with regard to the telomere/single-copy gene ratio, but a trend effect was observed between the combined intervention group and controls (F [1,84], 3.82; P 5 .054; h 2 5 .043); TL in the intervention group was maintained whereas it was found to decrease for control participants. There were no associations noted between changes in TL and changes in mood or stress scores over time. CONCLUSIONS: Psychosocial interventions providing stress reduction and emotional support resulted in trends toward TL maintenance in distressed breast cancer survivors, compared with decreases in usual care. Cancer 2015;121:476-84.

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Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome

Cited by 69 publications

References 49 publications

Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer

Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer

Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Mindfulness‐based cancer recovery and supportive‐expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors

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