Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Lü, Muhan; Deng, Jiaqi; Cao, Yunxia; Fang, Dian‐Chun; Zhang, Yao; Yang, Shi‐Ming

doi:10.3892/etm.2012.471

Cited by 19 publications

(14 citation statements)

References 41 publications

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“…Many studies have shown that hTERT is related to the unlimited growth of gastric cancer cells 7 8 . In addition, our previous study found that hTERT was highly expressed in GC tissues, we also proved that hTERT was positive related to the distant metastasis and lymphatic metastasis in patients with GC 9 . The overexpression of hTERT can significantly enhance the invasiveness and metastatic ability of the telomerase-negative osteosarcoma cell line U2OS 10 .…”

supporting

confidence: 64%

hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a

Xiao

Tang

et al. 2016

Sci Rep

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Human telomerase reverse transcriptase (hTERT) plays a key role in tumor invasion and metastasis, but the mechanism of its involvement in these processes is not clear. The purpose of this study is to investigate the possible molecular mechanism of hTERT in the promotion of gastric cancer (GC) metastasis. We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 (ITGB1). In addition, the invasive capacity of gastric cancer cells was also highly increased after hTERT overexpression. Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo. Taken together, our results suggested that hTERT may promote GC metastasis through the hTERT-miR-29a-ITGB1 regulatory pathway.

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supporting

confidence: 64%

hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a

Xiao

Tang

et al. 2016

Sci Rep

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“…It is worth noting that our results have some differences from a similar meta-analysis that examined TA and clinicopathological parameters in gastric cancer (32). Results from this previous study indicated that high TA expression tended to be associated with lymph node metastasis, the depth of invasion, distant metastasis, tumor size, and TNM stage.…”

Section: Discussioncontrasting

confidence: 50%

The Relationship between Telomerase Activity and Clinicopathological Parameters in Colorectal Cancer: A Meta-Analysis

Xie

Lai

et al. 2016

Balkan Med J

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Background:Recently, accumulated research has found that the expression of telomerase activity (TA) was associated with colorectal cancer (CRC) advancement, whereas the TA prognostic effect in CRC patients is still controversial. Aims: To investigate relationships between TA and CRC clinicopathological parameters. Study Design: Meta-analysis study. Methods:We searched published studies in databases, such as EMBASE, the Cochrane Library, PubMed, and Ovid databases (last search updated to October 2014) by meeting specified search criteria. The quality of the included studies was usually evaluated and a metaanalysis was implemented by Stata 12.0 software. We used an odds ratio (OR) with a 95% confidence interval (CI) to evaluate relationship strengths between TA and CRC clinicopathological parameters. Results: In total, 11 studies (715 patients) were included to assess the relation between TA and metastasis-related parameters in CRC patients. The results indicate that a senior TA expression was connected with the existence of lymph node metastasis (180 patients; OR=2.85, 95% CI=1.40-5.81, p=0.004), and tumor site (522 Colorectal cancer (CRC) is the third most general neoplasm in humans with the CRC mortality rate accounting for around 9% of all tumor deaths (1). The 5-year survival rate of the early stages of CRC after surgical resection is around 85%, while this rate is meaningfully decreased (<50%) in lymph node metastasis positive CRC patients (2). Therefore, early and more accurate detection of tumorigenesis or progression is critical to enhancing therapeutic strategy and prognosis of patients. Accumulating evidence indicates that cellular immortality plays an important role in tumor biology (3).The indispensable and key factor for tumor immortalization and tumorigenesis is telomerase, an enzyme that protects DNA sequences on chromosome ends. Telomerase can prevent cellular senescence in somatic cells through synthesizing

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“…Specifically, it has been shown how ectopic expression of miR-1207-5p in the SGC7901 gastric tumor cell line is able to reduce proliferation and invasion in vitro and in vivo by targeting the catalytic subunit of the telomerase complex hTERT (52). Aberrant expression of hTERT is associated with the metastatic ability of gastric tumors (114,115). In turn, miR-1207-5p overexpression in the HCoEpiC normal colon epithelial cell line enables the formation of primary and secondary spheres by a mechanism involving the upregulation at the mRNA level of TGFβ, CTNNB1, MMP2 and several colorectal stem cell markers such as CD44, CD133, and CD166 (81).…”

Section: Oncogenic Pvt1 Functions In Colorectal and Gastric Cancermentioning

confidence: 99%

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

2020

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Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.

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Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Cited by 19 publications

References 41 publications

hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a

hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a

The Relationship between Telomerase Activity and Clinicopathological Parameters in Colorectal Cancer: A Meta-Analysis

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

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