The Relationship between Telomerase Activity and Clinicopathological Parameters in Colorectal Cancer: A Meta-Analysis

Abstract

Background:Recently, accumulated research has found that the expression of telomerase activity (TA) was associated with colorectal cancer (CRC) advancement, whereas the TA prognostic effect in CRC patients is still controversial. Aims: To investigate relationships between TA and CRC clinicopathological parameters. Study Design: Meta-analysis study. Methods:We searched published studies in databases, such as EMBASE, the Cochrane Library, PubMed, and Ovid databases (last search updated to October 2014) by meeting specified search criteria. The quality of the included studies was usually evaluated and a metaanalysis was implemented by Stata 12.0 software. We used an odds ratio (OR) with a 95% confidence interval (CI) to evaluate relationship strengths between TA and CRC clinicopathological parameters. Results: In total, 11 studies (715 patients) were included to assess the relation between TA and metastasis-related parameters in CRC patients. The results indicate that a senior TA expression was connected with the existence of lymph node metastasis (180 patients; OR=2.85, 95% CI=1.40-5.81, p=0.004), and tumor site (522 Colorectal cancer (CRC) is the third most general neoplasm in humans with the CRC mortality rate accounting for around 9% of all tumor deaths (1). The 5-year survival rate of the early stages of CRC after surgical resection is around 85%, while this rate is meaningfully decreased (<50%) in lymph node metastasis positive CRC patients (2). Therefore, early and more accurate detection of tumorigenesis or progression is critical to enhancing therapeutic strategy and prognosis of patients. Accumulating evidence indicates that cellular immortality plays an important role in tumor biology (3).The indispensable and key factor for tumor immortalization and tumorigenesis is telomerase, an enzyme that protects DNA sequences on chromosome ends. Telomerase can prevent cellular senescence in somatic cells through synthesizing

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