Telomerase activation in the treatment of aging or degenerative diseases: a systematic review

Prieto-Oliveira, P.

doi:10.1007/s11010-020-03929-x

Cited by 11 publications

(2 citation statements)

References 103 publications

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“…Since most human somatic cells have low or no telomerase activity, it results in age-related telomere erosion and associated pathological processes. Therefore, activation of telomerase is regarded by several authors as promising therapeutic modality in the treatment of degenerative aging disorders (Bernardes de Jesus and Blasco, 2011 ; Prieto-Oliveira, 2020 ). However, even although telomerase indeed has potential in anti-aging medicine, the fact that it is over-expressed in about 90% of human cancers raises doubts about the applicability of telomerase activators in clinical practice (Smith-Sonneborn, 2020 ).…”

Section: Basic Principles Of Telomere Biologymentioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mortality. Evidence is obtained that other indicators such as certain immune parameters, indices of epigenetic age, etc., could be stronger predictors of the health status and the risk of chronic disease. However, despite these issues and limitations, TL remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. This review article is aimed at describing the current state of the art in the field and at discussing recent research findings and divergent viewpoints regarding the usefulness of leukocyte TL for estimating the human biological age.

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Section: Basic Principles Of Telomere Biologymentioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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“…38 Hence, considering the biological significance of telomerase in the maintenance of TL, telomerase activators have been considered as a promising anti-ageing therapeutic option for degenerative disorders. 136,137 In contrast, telomerase is reactivated in most human malignancies, and this has cast doubts on the clinical applicability of telomerase activator. 138…”

Section: Telomere Shortest Length Assaymentioning

confidence: 99%

Telomere and Telomerase Biology in Cardiovascular Disease: A State-of-the-art Review and Outlook

Tan,

Fong

2023

J Asian Pac Soc Cardiol

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Telomeres are short repetitive hexanucleotides located at the ends of eukaryotic DNA sequences. They progressively shorten with each mitotic cycle, and telomerase counteracts the process by regulating and extending the telomeres. Ageing, oxidative stress and inflammation are predisposing factors that accelerate telomere shortening, and eventually drive cells to senescence. Recent findings have observed the associations of short telomere length with traditional cardiovascular risk factors leading to cardiovascular phenotype. However, such association remains hypothesised as a reserved causation, mainly confounded by unfathomable covariates and mixed research findings. Based on the recent literature, the present review aimed to provide a concise update and diverging view on telomere−telomerase biology in cardiovascular disease.

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Melatonin in Aging and Aging-Related Disorders

Süzen¹

2023

Emerging Anti-Aging Strategies

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Telomerase activation in the treatment of aging or degenerative diseases: a systematic review

Cited by 11 publications

References 103 publications

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Telomere and Telomerase Biology in Cardiovascular Disease: A State-of-the-art Review and Outlook

Melatonin in Aging and Aging-Related Disorders

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