Melatonin in Aging and Aging-Related Disorders

Süzen, Síbel

doi:10.1007/978-981-19-7443-4_9

Cited by 2 publications

(2 citation statements)

References 242 publications

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“…The amplitudes of each mode for the model fit with the lowest RSME was obtained from the Hilbert transform of the corresponding intrinsic mode functions and the mode periods were calculated as the inverse of the frequency output of the WSST. Weighted histograms were created in Matlab by aggregating all mode frequencies from the ANH fit with the lowest RMSE and adjusting the amplitudes by their corresponding angular frequencies and normalizing the data to the frequency bin with the largest amplitude [105].…”

Section: Methodsmentioning

confidence: 99%

“…Beeswarm plots (Figures 3F, 4C-D, 5B and 6D) were generated in Matlab adapting code from [109]. Wind Weighted histograms (Figure 2C, 3E-F, 4E, 5C and Supplemental Figure 2A-B [105]) were generated from Matlab scripts from the Matlab central File exchange. Statistical significance was determined using a two-tailed Student’s t test or one way ANOVA followed by a Dunnet test for multiple comparison with the same control using corresponding Matlab functions.…”

Section: Figures and Statistical Analysismentioning

confidence: 99%

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Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

Werner,

Ray,

Breen

et al. 2023

Preprint

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Contractile force generation by the cortical actomyosin cytoskeleton is essential for a multitude of biological processes. The actomyosin cortex behaves as an active material that drives local and large-scale shape changes via cytoskeletal remodeling in response to biochemical cues and feedback loops. Cytokinesis is the essential cell division event during which a cortical actomyosin ring generates contractile force to change cell shape and separate two daughter cells. Our recent work with active gel theory predicts that actomyosin systems under the control of a biochemical oscillator and experiencing mechanical strain will exhibit complex spatiotemporal behavior, but cytokinetic contractility was thought to be kinetically simple. To test whether active materialsin vivoexhibit spatiotemporally complex kinetics, we used 4-dimensional imaging with unprecedented temporal resolution and discovered sections of the cytokinetic cortex undergo periodic phases of acceleration and deceleration. Quantification of ingression speed oscillations revealed wide ranges of oscillation period and amplitude. In the cytokinetic ring, activity of the master regulator RhoA pulsed with a timescale of approximately 20 seconds, shorter than that reported for any other biological context. Contractility oscillated with 20-second periodicity and with much longer periods. A combination ofin vivoandin silicoapproaches to modify mechanical feedback revealed that the period of contractile oscillation is prolonged as a function of the intensity of mechanical feedback. Effective local ring ingression is characterized by slower speed oscillations, likely due to increased local stresses and therefore mechanical feedback. Fast ingression also occurs where material turnover is high,in vivoandin silico. We propose that downstream of initiation by pulsed RhoA activity, mechanical positive feedback, including but not limited to material advection, extends the timescale of contractility beyond that of biochemical input and therefore makes it robust to fluctuations in activation. Circumferential propagation of contractility likely allows sustained contractility despite cytoskeletal remodeling necessary to recover from compaction. Our work demonstrates that while biochemical feedback loops afford systems responsiveness and robustness, mechanical feedback must also be considered to describe and understand the behaviors of active materialsin vivo.

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Section: Methodsmentioning

confidence: 99%

Section: Figures and Statistical Analysismentioning

confidence: 99%

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

Werner,

Ray,

Breen

et al. 2023

Preprint

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Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury

Tozihi

Shademan

Yousefi

et al. 2023

Front. Aging Neurosci.

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Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial event. The reperfusion process impairs critical cascades that support cell survival, including mitochondrial biogenesis and antioxidant enzyme activity. Failure to activate prosurvival signals may result in increased neuronal cell death and exacerbation of CIR damage. Melatonin, a hormone produced naturally in the body, has high concentrations in both the cerebrospinal fluid and the brain. However, melatonin production declines significantly with age, which may contribute to the development of age-related neurological disorders due to reduced levels. By activating various signaling pathways, melatonin can affect multiple aspects of human health due to its diverse range of activities. Therefore, understanding the underlying intracellular and molecular mechanisms is crucial before investigating the neuroprotective effects of melatonin in cerebral ischemia-reperfusion injury.

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Melatonin in Aging and Aging-Related Disorders

Cited by 2 publications

References 242 publications

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury

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