Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis
Michael E. Werner,
Dylan D. Ray,
Coleman Breen
et al.
Abstract:Contractile force generation by the cortical actomyosin cytoskeleton is essential for a multitude of biological processes. The actomyosin cortex behaves as an active material that drives local and large-scale shape changes via cytoskeletal remodeling in response to biochemical cues and feedback loops. Cytokinesis is the essential cell division event during which a cortical actomyosin ring generates contractile force to change cell shape and separate two daughter cells. Our recent work with active gel theory pr… Show more
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