Telocytes are the physiological counterpart of inflammatory fibroid polyps and <i><scp>PDGFRA</scp></i>‐mutant <scp>GIST</scp>s

Ricci, Riccardo; Giustiniani, Maria Cristina; Gessi, Marco; Lanza, Paola; Castri, Federica; Biondi, Alberto; Persiani, Roberto; Vecchio, Fabio Maria; Risio, Mauro

doi:10.1111/jcmm.13748

Cited by 33 publications

(22 citation statements)

References 34 publications

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“…Therefore, most authors consider that GISTs derive from, or differentiate towards, the interstitial cells of Cajal (ICC) lineage [ 93 , 94 , 95 , 96 , 97 ]. Likewise, TCs and PDGFRa, a marker of TCs [ 33 , 98 , 99 ] are related to GISTs (familial PDGFRa-mutation syndrome) [ 94 , 100 , 101 , 102 ].…”

Section: Tcs (Tcs/cd34+scs) In the Pathologic Peripheral Nervous Smentioning

confidence: 99%

Telocytes in the Normal and Pathological Peripheral Nervous System

Díaz‐Flores

Gutiérrez

García

et al. 2020

IJMS

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We studied telocytes/CD34+ stromal cells in the normal and pathological peripheral nervous system (PNS), for which we reviewed the literature and contributed our observations under light and electron microscopy in this field. We consider the following aspects: (A) general characteristics of telocytes and the terminology used for these cells (e.g., endoneurial stromal cells) in PNS; (B) the presence, characteristics and arrangement of telocytes in the normal PNS, including (i) nerve epi-perineurium and endoneurium (e.g., telopodes extending into the endoneurial space); (ii) sensory nerve endings (e.g., Meissner and Pacinian corpuscles, and neuromuscular spindles); (iii) ganglia; and (iv) the intestinal autonomic nervous system; (C) the telocytes in the pathologic PNS, encompassing (i) hyperplastic neurogenic processes (neurogenic hyperplasia of the appendix and gallbladder), highly demonstrative of telocyte characteristics and relations, (ii) PNS tumours, such as neurofibroma, schwannoma, granular cell tumour and nerve sheath myxoma, and interstitial cell of Cajal-related gastrointestinal stromal tumour (GIST), (iii) tumour-invaded nerves and (iv) traumatic, metabolic, degenerative or genetic neuropathies, in which there are fewer studies on telocytes, e.g., neuroinflammation and nerves in undescended testicles (cryptorchidism), Klinefelter syndrome, crush injury, mucopolysaccharidosis II (Hunter’s syndrome) and Charcot–Marie–Tooth disease.

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Section: Tcs (Tcs/cd34+scs) In the Pathologic Peripheral Nervous Smentioning

confidence: 99%

Telocytes in the Normal and Pathological Peripheral Nervous System

Díaz‐Flores

Gutiérrez

García

et al. 2020

IJMS

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“…Besides IBD, recent evidence suggests that the TCs might be a cell source of certain kinds of gastrointestinal stromal tumors (GIST) [55]. While ICCs hyperplasia has been identified as a crucial pathogenic feature of KIT-mutant GIST, it has been proposed that the TCs could represent the physiological counterpart of PDGFRa-mutant GIST and inflammatory fibroid polyps [55]. Indeed, a pathogenic relationship between TCs hyperplasia and both inflammatory fibroid polyps and PDGFRa-mutant GIST has been suggested.…”

Section: Telocyte Network In Gastrointestinal Diseasesmentioning

confidence: 99%

“…Indeed, a pathogenic relationship between TCs hyperplasia and both inflammatory fibroid polyps and PDGFRa-mutant GIST has been suggested. Moreover, the term "telocytoma" was proposed for defining inflammatory fibroid polyps, since it conveys both the pathogenic (neoplastic) and histotypic ("telocytary") nature of this tumor [55].…”

Section: Telocyte Network In Gastrointestinal Diseasesmentioning

confidence: 99%

Telocytes: New Connecting Devices in the Stromal Space of Organs

Crețoiu¹,

Vannucchi²,

Bei³

et al. 2020

Innovations in Cell Research and Therapy

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Telocytes (TCs) represent a new type of interstitial cells, and were discovered by Prof. Popescu and his collaborators from Bucharest in 2005, and described as Interstitial Cajal-Like Cells (ICLCs). In 2010, Prof. Popescu and Prof. Faussone-Pellegrini from Florence, based on their expertise in morphology, agreed that in fact ICLCs were a brand-new entity and they renamed them telocytes. TCs are characterized by specific veil-or ribbon-like extensions called telopodes. Telopodes aid TCs in forming homo-or hetero-cellular contacts; thus, assembling three-dimensional networks that organizes the stromal and the parenchymal components of the organs. TCs can transfer information to neighbor cells ensuring a short-distance communication, and remotely by the release a wide variety of extracellular vesicles: exosomes, ectosomes, and multivesicular bodies. Here, we reviewed the evolution of the interest regarding TCs in different organs, in normal and pathological conditions. The main focus was on the role of TCs in gastrointestinal tract, urinary bladder, reproductive tract, and heart. This chapter sums up information about the possibilities that TCs are capable to behave as sensors/mediators in nervous activity, to represent mesenchymal stem cell precursors in adulthood, and to control and determine the differentiation/maturation of other cell types either during development or in postnatal life.

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“…As exceptional interstitial connecting devices, TCs are supposed to be committed to intercellular signaling likely making a significant contribution to tissue morphogenetic and developmental processes, homeostatic balance, immunosurveillance as well as reparative/regenerative mechanisms by supporting local stem cell niche maintenance and differentiation or performing themselves as progenitors 1–4,30–35 . Besides tissue physiologic conditions, the notion that TCs may undergo interesting variations in a number of pathologic states suggests either their possible pathogenetic implications or their potentiality as target cells for regenerative medicine purposes 36–42 .…”

Section: Introductionmentioning

confidence: 99%

Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue

Rosa

Taverna

Novelli

et al. 2019

Sci Rep

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Telocytes have recently emerged as unique interstitial cells defined by their extremely long, thin and moniliform prolongations termed telopodes. Despite growing evidence that these cells consistently reside in the stromal compartment of various organs from human beings, studies dealing with telocytes in structures of the oral cavity are scarce. Hence, the present morphologic study was undertaken to explore for the first time the presence and specific localization of telocytes within tissues of the normal human tongue, a complex muscular organ whose main functions include taste, speech, and food manipulation in the oral cavity. Telocytes were initially identified by CD34 immunostaining and confirmed by CD34/PDGFRα double immunofluorescence and transmission electron microscopy. CD34+/PDGFRα+ telocytes were organized in interstitial meshworks either in the tongue lamina propria or in the underlying striated muscle. Lingual telocytes were immunonegative for CD31, c-kit and α-SMA. Telopodes were finely distributed throughout the stromal space and concentrated beneath the lingual epithelium and around CD31+ vessels, skeletal muscle bundles/fibers, and intramuscular nerves and ganglia. They also enveloped salivary gland units outside the α-SMA+ myoepithelial cells and delimited lymphoid aggregates. These findings establish telocytes as a previously overlooked interstitial cell population worth investigating further in the setting of human tongue pathophysiology.

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Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA‐mutant GISTs

Cited by 33 publications

References 34 publications

Telocytes in the Normal and Pathological Peripheral Nervous System

Telocytes in the Normal and Pathological Peripheral Nervous System

Telocytes: New Connecting Devices in the Stromal Space of Organs

Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue

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