Telmisartan in the hypertension treatment: from pharmacological characteristics to clinical benefits

Саютина, Е. В.; Butorova, L. I.; Туаева, Е. М.; Осадчук, М А

doi:10.15829/1728-8800-2020-1-2453

Cited by 1 publication

(2 citation statements)

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“…По данным литературы, сочетание АГ и хронической обструктивной болезни легких (ХОБЛ) встречается в 34,3% случаев [1,4]. Пациенты с АГ и ХОБЛ имеют особенно высокий сердечно-сосудистый риск [2,5,6]. Эти заболевания имеют много общих факторов риска, кроме того, риск возрастает вследствие гипоксии, хронического воспаления в бронхах, повреждения эндотелия сосудов, активации свободнорадикального окисления [2,6,7].…”

Section: оригинальные исследования Original Researchunclassified

“…В связи с этим лечение АГ при ХОБЛ должно включать медикаментозную терапию и рекомендации по изменению образа жизни [1-3, 7, 8]. Согласно современным отечественным рекомендациям, блокаторы ренин-ангиотензин-альдостероновой системы, представителями которых являются ингибиторы ангиотензинпревращающего фермента и блокаторы ре-цепторов ангиотензина, сохранили лидирующее значение среди основных классов антигипертензивных препаратов и рассматриваются в настоящее время как базовые лекарственные средства, в том числе в составе комбинированной терапии [2,5], которая позволяет подавить контррегуляторные механизмы повышения АД. Все преимущества такой терапии присущи только рациональным комбинациям антигипертензивных препаратов, одной из таких комбинаций у больных ХОБЛ является сочетание блокатора рецепторов ангиотензина и антагониста кальция пролонгированного действия [1,4,5].…”

Section: оригинальные исследования Original Researchunclassified

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Increased adherence to the treatment of comorbid patients with arterial hypertension and chronic obstructive pulmonary disease on the background of complex therapy

Меньшикова

Magalyas

Sklyar

et al. 2021

Bûlletenʹ fiziologii i patologii dyhaniâ

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Aim. To determine the adherence to treatment of patients with arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) against the background of complex therapy.Materials and methods. We examined 56 patients with stage II hypertension in combination with COPD. Men accounted for 70%, women – 30%. The average age of patients is 52.9±0.46 years. The patients were prescribed a fixed combination of antihypertensive drugs – telmisartan 40 mg with amlodipine 5 mg and COPD therapy according to GOLD. Patients of group 1 (n=30) studied at a health school against the background of drug treatment, patients in group 2 (n=26) did not attend a health school.Results. After 6 months of treatment, the number of patients in group 1 increased (p=0.001) regularly taking antihypertensive drugs, 96.7% of patients began to independently control blood pressure and keep a diary of a patient with hypertension. Patients of group 2 showed a statistically significant increase in the level of awareness of the presence of the disease and the awareness of patients about the risk factors for the development of the disease (p=0.01), although the number of patients controlling blood pressure remained low (p=0.1). In group 1, there was a positive trend in terms of the main risk factors, in group 2 the frequency of the prevalence of risk factors practically did not change. By the 6th month of therapy, all patients in group 1 achieved the target blood pressure, in group 2 – in 73.1% of patients. By the end of the observation, in patients of group 1, against the background of the chosen treatment tactics, there was a significantly more significant decrease in left ventricular mass index (LVMI) with its normalization in 33.3% of patients, indicating regression of LV hypertrophy (p=0.01), as well as a significant increase in the ratio of peak velocities on the mitral valve (E/A), (p=0.01), indicating an improvement in LV diastolic function. In group 2, antihypertensive therapy showed a moderate decrease in LVMI (p=0.1) with normalization of this indicator in only 2 (7.7%) of patients. By the 6th month of treatment, an improvement in the parameters of bronchial patency was revealed, however, in the 2nd group of patients, the changes in these parameters were statistically insignificant.Conclusion. The effectiveness of the treatment of hypertension and COPD depends not only on the choice of the optimal treatment tactics, but also on the patient's compliance with the prescribed therapy regimen. The results obtained indicate a positive effect of the chosen complex treatment regimen on the functional parameters of the left ventricle and bronchial patency.

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Section: оригинальные исследования Original Researchunclassified