Telithromycin-Induced TEN: Report of a Case

Bédard, Marie-Sophie

doi:10.1001/archderm.143.3.427

Cited by 10 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30 In two other cases, skin eruption appeared after taking the first dose of the second course of telithromycin, which was prescribed after symptoms of pharyngitis developed. 35,36 In this case, it is difficult to say that the patient's re-exposure to telithromycin precipitated the reaction since it usually progresses over 4 to 5 days. 36 The summary of treatment for each patient is given in Complications of the healing in one patient with azithromycin associated SJS included restricted mouth opening owing to adhesion of the lips (lip synechiae) which required treatment with bilateral chalinoplasty.…”

Section: Resultsmentioning

confidence: 96%

“…28 One patient with telithromycin-induced TEN had dermatologic sequelae such as cutaneous scarring, hyperpigmentation, scarring alopecia, and milium formations. 35 One patient with clarithromycin-induced SJS was feeling well, but slight discoloration persisted at the place of skin lesions. 26 One patient with erythromycin-induced SJS developed webbing of both oral commissures causing slightly restricted mouth opening but no interference with normal activities.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the literature search are shown in Figure 1. Twenty‐five publications describing a total of 27 patients were included in the review: 23 case reports 14–36 having one patient in each and two case series 6,37 (details of two patients from each case series were relevant for this review). Figure 2 shows the quality assessment of the identified cases.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Stevens‐Johnson syndrome and toxic epidermal necrolysis associated with the use of macrolide antibiotics: a review of published cases

Pejčić

2020

Int J Dermatology

View full text Add to dashboard Cite

Macrolides are one of the most commonly prescribed antibiotics. In several studies, their use was associated with the occurrence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This review aimed to explore and summarize available cases of SJS/TEN suspected to be associated with the use of macrolide antibiotics reported in the literature. Electronic searches were conducted in PubMed/MEDLINE, Web of Science, Scopus, and Serbian Citation Index (SCIndeks). Twenty-five publications describing a total of 27 patients were included. Cases of SJS/TEN which satisfied inclusion criteria were found for azithromycin (n = 11), clarithromycin (n = 7), erythromycin (n = 5), roxithromycin (n = 2), and telithromycin (n = 2). The age of the patients ranged from 2 to 77 years (median: 29 years). There were 14 female (51.9%) and 13 male (48.1%) patients. SJS was diagnosed in 16 patients (59.3%), TEN in 10 patients (37.0%), and SJS/TEN overlap in one patient (3.7%). Time to onset of the first symptoms ranged from 1 to 14 days (median: 3 days). All patients received some form of supportive and symptomatic care. Systemic corticosteroids were reported to be administered in 12 patients (44.4%) and intravenous immunoglobulin in five patients (18.5%). Three patients (11.1%) died. Considering that SJS/TEN is a severe and potentially life-threatening reaction, physicians should be aware that they could be adverse effects of macrolide antibiotics and keep in mind that prompt recognition of SJS/TEN and discontinuation of the culprit drug in combination with supportive care is essential.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Stevens‐Johnson syndrome and toxic epidermal necrolysis associated with the use of macrolide antibiotics: a review of published cases

Pejčić

2020

Int J Dermatology

View full text Add to dashboard Cite

show abstract

“…Hypersensitivity reactions to macrolides are rare, with urticaria and angioedema being the most common symptoms (112,115,183). Descriptions of telithromycin hypersensitivity are anecdotal [ 186 , 187 ]. A report exists of a life-threatening immediate-type hypersensitivity reaction after the first administration of telithromycin prescribed for an upper respiratory tract infection [ 186 ].…”

Section: Telithromycinmentioning

confidence: 99%

“…They are collectively known as derivatives of polycyclic naphthacene carboxamide [ 189 ]. Classical natural occurring members of this group are: tetracycline, chlortetracycline, oxytetracycline, declocycline and other semisynthetic like doxycycline and minocycline [ 187 ]. They are amphoteric antibiotics forming acid or basic salts which are soluble in water.…”

Section: Tetracyclinesmentioning

confidence: 99%

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

Sánchez‐Borges

Thong

Blanca

et al. 2013

World Allergy Organization Journal

View full text Add to dashboard Cite

Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among the most important agents involved in adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J Allergy Clin Immunol 113:832–836, 2004]. Most studies published to date deal mainly with reactions to the beta-lactam group, and information on hypersensitivity to each of the other antimicrobial agents is scarce. The present document has been produced by the Special Committee on Drug Allergy of the World Allergy Organization to present the most relevant information on the incidence, clinical manifestations, diagnosis, possible mechanisms, and management of hypersensitivity reactions to non beta-lactam antimicrobials for use by practitioners worldwide.

show abstract