Erythema Multiforme, Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Breathnach, S.M.; BChir,; Dermatologist, Frcp Consultant

doi:10.1002/9781444317633.ch76

Cited by 22 publications

(24 citation statements)

References 449 publications

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“…[5] Females appear to have a greater predilection for developing toxic epidermal necrolysis than males. [6] Though the main culprit drugs include sulfonamides, antiepileptic drugs, ampicillin, allopurinol and NSAIDs, toxic epidermal necrolysis is rarely reported with ciproß oxacin. [6] Agranulocytosis is another rare life threatening complication of ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Though the main culprit drugs include sulfonamides, antiepileptic drugs, ampicillin, allopurinol and NSAIDs, toxic epidermal necrolysis is rarely reported with ciproß oxacin. [6] Agranulocytosis is another rare life threatening complication of ciprofloxacin. [3] The overall incidence of non chemotherapy drug induced agranulocytosis ranges from 2.6 to 10 cases per million patients exposed to drugs per year.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Toxic epidermal necrolysis and agranulocytosis: Rare adverse effects of ciprofloxacin

Upadya¹,

Ruxana²

2009

Indian J Med Sci

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis and agranulocytosis: Rare adverse effects of ciprofloxacin

Upadya¹,

Ruxana²

2009

Indian J Med Sci

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“…SJS/TEN are of major concern because of severe morbidity and high mortality rates reported from less than 10% in SJS patients to more than 40% in TEN patients (overall 20-25%) (Valeyrie-Allanore and Roujeau, 2008;Breathnach, 2010). Because of the rareness of the reaction (Europe: 1.5-2 patients/year/million people), knowledge is often derived from case reports or small cohorts, leaving several questions unanswered (Naldi et al, 1990;Roujeau et al, 1990;Rzany et al, 1996).…”

Section: Introductionmentioning

confidence: 98%

“…Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions (SCAR) mainly induced by drugs (Valeyrie-Allanore and Roujeau, 2008;Mockenhaupt, 2009;Breathnach, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Survival Analysis of a Cohort of Patients with Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Sekula

Dunant

Mockenhaupt

et al. 2013

Journal of Investigative Dermatology

363

280

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Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous adverse reactions that are of major concern because of high mortality rates. On the basis of data collected in the RegiSCAR study, the aim was to assess risk factors (including modalities of patient management) for mortality, regardless of the cause, up to 1 year after the reaction. Within this cohort, the mortality rate was 23% (95% confidence interval (CI) 19-27%) at 6 weeks and 34% (95% CI 30-39%) at 1 year. Severity of reaction was a risk factor for mortality only in the first 90 days after onset, whereas serious comorbidities and age influenced mortality beyond 90 days and up to 1 year after onset of reaction. The risk of death for patients with identified drug cause was borderline lower than for patients with a reaction of unknown cause (hazard ratio 0.66, 95% CI 0.45-0.96). The study could not provide conclusive evidence regarding patient management. This large-scale population-based follow-up study of such patients confirmed high in-hospital mortality and revealed a remarkable number of deaths after discharge, which could mainly be attributed to severe comorbidities and older age, whereas the impact of severity of reaction on the risk of death was limited to the first few weeks.

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“…4 Clinically it presents as macular, papular or urticarial lesions as well as the classical "target lesions" distributed preferentially on the distal extremities. 5 Cases of Herpes associated erythema multiforme (HAEM) can often be confused with Steven-Johnsons syndrome (SJS) and Toxic epidermal necrolysis (TEN). HAEM can be distinguished from SJS by the presence of typical target lesions on the skin with or without mucosal involvement.…”

Section: Introductionmentioning

confidence: 99%