“…As shown in Figure 2, when viruses, such as iridoviruses, herpesviruses, reoviruses, or rhabdoviruses attempt to enter a host cell, they first meet physical barriers on the skin and interact with a continuous layer of mucus and the complex regulatory networks that control skin immunity [163][164][165][166]. After such viruses pass the first line of defense and enter the host cell, the infected cell immediately initiates a series of innate immune responses; these include an inflammatory response, complement system activation, interferon production, induction of antiviral reactions, cell apoptosis, and innate immune cell responses from macrophages, neutrophils, dendritic cells, natural killer and other immune cells that prevent viral replication and inhibit virus propagation [153,156,167].…”