Tekrarlayan Venöz Tromboemboli’ye Trombofilik Gen Mutasyonunun Etkisi: Geriye-Dönük Kesitsel Bir Araştırma

Abstract

The aim of this study is to evaluate the influence of the risk factors from the point of thrombophilic gene mutations (TGM) with type and inter-cooperation's on recurrence in venous thromboembolism (VTE) patients.This retrospectively and crosssectionally designed study was conducted between 2008-2009. The VTE patients, who were evaluated for TGM were elected. Among a total of 109 patients, the mean age at first VTE event was 42.6±14.1 years. Fifty-nine (54.1%) patients were male. While 33 (30.3%) patients had primary VTE, 46 (42.2%) patients had recurrent VTE (rVTE). In the univariate analysis, the significant variables associated with the increased rate of rVTE were age ≥40 years, first event at in-hospital, malignancy, internal medical disease, TGM, factor V Leiden, prothrombin G20210A. The analyses of different mutation count on rVTE pointed that, there were significant differences in recurrence rates, except groups with no mutation and one mutation. Additionally, the increasing number of clinical risk factors and TGM per case were considerably associated with rVTE in both univariate and multivariate analysis. Regarding the risk of rVTE, the TGMs were significant but do not appear to play a vital role per se. However, simultaneous existence of clinical risk factors, including TGM seem to be more important for the prediction of rVTE.