Teichoic Acid Antibodies in Staphylococcal and Nonstaphylococcal Endocarditis

Western blot analysis of staphylococcal antibodies present in human sera during health and disease

“…Recent work on such antibodies has centred on the development of serological tests for deepseated staphylococcal disease. Several antibodies have been assessed for their diagnostic potential, including those directed against a haemolysin (Towers and Gladstone, 1958 ;Larinkari and Valtonen, 1984), teichoic acid (Crowder and White, 1972;Shaegren, 1984), y haemolysin (Taylor and Plommet, 1973) and staphylococcal nuclease (Taylor et al, 1976). Their value in the diagnosis of deep-seated infection is limited (Parker, 1984).…”

Occurrence of antibodies to teichoic acid in patients with diseases other than staphylococcal infection

“…In patients without S. aureus infection, TAA has most often been reported in patients with endocarditis or bacteraemia caused by streptococci or pneumococci, S. epidermidis, diphtheroids and E. coli (Crowder and White, 1972;Hoppes and White, 1975;Nagel et al, 1975;Larinkari et al, 1977;Leffell et al, 1978;Tuazon et al, 1978;Tenenbaum and Archer, 1980).…”

“…Cross-reactions can be expected in TAA assay, because many gram-positive and also some gram-negative bacteria have structures that are antigenically similar to 'those of the ribitol teichoic acids of S. aureus (Juergens, Sanderson and Strominger, 1963;Brundish and Baddiley, 1968;Kane and Karakawa, 1969;Aasen and Oeding, 1971;Argaman, Liu and Robbins, 1974;Gmeiner et al, 1977). In practice, however, false positive TAA test results have been fairly uncommon (Crowder and White, 1972;Larinkari et al, 1977, Leffell, Folds andWasilauskas, 1978;Martin, Greenberg and Wallace, 1979). They have been found usually in low titres in some patients with streptococcal and diphtheroid endocarditis, (Hoppes and White, 1975;Nagel et al, 1975;Tuazon et al, 1978;Bayer et al, 1980).…”

“…Especially high TAA titres have been found in staphylococcal endocarditis and in other complicated staphylococcal infectibns with metastatic abscess formation (Crowder and White, 1972;Nagel et al, 1975;Tuazon and Sheagren, 1976;Tuazon et al, 1978;Wheat et al, 1978;Bayer et al, 1980;Tenenbaum and Archer, 1980). Patients with atopic dermatitis often have high TAA titres without evidence of clinical infection (Larinkari, 1982a).…”

Antibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis

“…Bound human IgG was detected by phosphatase-conjugated mouse anti-human antibodies, and the optical density at 405 nm was recorded at 30-min intervals over 2 h (21). The titers of IgG antibodies for teichoic acid and alpha-toxin were within the range seen by using a commercial enzyme-linked immunosorbent assay (4,6,9,23). Titers of IgG antibodies against the recombinant Bbp protein were lower by 1 order of magnitude within the 2-h development time (Table 1).…”