Occurrence of antibodies to teichoic acid in patients with diseases other than staphylococcal infection

Larinkari, Ulla; Leirisalo, M; Pentikäinen, Pertti J.; Turunen, Ulla; Pikkarainen, P; Vuoristo, Matti; Lumio, Jukka; Räsänen, Tarja; Valtonen, Ville

doi:10.1099/00222615-16-1-45

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…In this context, an association between S. aureus and human lupus has been documented in many reports. Lupus patients have high levels of antibodies to staphylococcal lipoteichoic acid (58) and staphylococcal DNA (59). Induction or flare of SLE and cutaneous lesions has been described following an infection with S. aureus (60).…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Chowdhary

Tilahun

Clark

et al. 2012

The Journal of Immunology

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Chronic nasal and skin colonization with superantigen (SAg)-producing Staphylococcus aureus is well documented in humans. Given that trans-mucosal and trans-cutaneous absorption of SAgs can occur, we determined whether chronic exposure to small amounts of SAg per se could activate autoreactive CD4+ and CD8+ T cells and precipitate any autoimmune disease without further external autoantigenic stimulation. Because HLA class II molecules present SAg more efficiently than do mouse MHC class II molecules, HLA-DQ8 transgenic mice were implanted s.c. with mini-osmotic pumps capable of continuously delivering the SAg, staphylococcal enterotoxin B (total of 10 μg/mouse), or PBS over 4 wk. Chronic exposure to staphylococcal enterotoxin B resulted in a multisystem autoimmune inflammatory disease with features similar to systemic lupus erythematosus. The disease was characterized by mononuclear cell infiltration of lungs, liver, and kidneys, accompanied by the production of anti-nuclear Abs and deposition of immune complexes in the renal glomeruli. The inflammatory infiltrates in various organs predominantly consisted of CD4+ T cells bearing TCR Vβ8. The extent of immunopathology was markedly reduced in mice lacking CD4+ T cells and CD28, indicating that the disease is CD4+ T cell mediated and CD28 dependent. The absence of disease in STAT4-deficient, as well as IFN-γ–deficient, HLA-DQ8 mice suggested the pathogenic role of Th1-type cytokines, IL-12 and IFN-γ. In conclusion, our study suggests that chronic exposure to extremely small amounts of bacterial SAg could be an etiological factor for systemic lupus erythematosus.

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Section: Discussionmentioning

confidence: 99%

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Chowdhary

Tilahun

Clark

et al. 2012

The Journal of Immunology

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“…Information on ASTA and TAA in rheumatology is mainly based on septic arthritis and osteomyelitis in which they are considered to be fairly specific to Staphylococcus aureus infection but not very sensitive serological tests (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). A high ASTA titre has also been found Legend to Table I: * = One patient with ankylosing spondylitis had a high salmonella titre.…”

Section: Discussionmentioning

confidence: 95%

“…Watson and Kerr (41,42) have reported high ASO titre in some patients having documented staphylococcal infections. On the other hand, high TAA has been found in some patients with streptococcal throat infection (29).…”

Section: Discussionmentioning

confidence: 99%

“…Antistaphylolysin is another test used in infections caused by Staphylococcus aureus. Both these serological tests are considered to be reasonably specific but not very sensitive (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). High titres of antistaphylolysin and teichoic acid antibody are seldom seen together in culture-verified Staphylococcus aureus infections (25).…”

Section: Introductionmentioning

confidence: 98%

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Association between high antistaphylolysin and teichoic acid antibody titres with rheumatic syndromes

1997

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To analyse which rheumatic syndromes are associated with serological evidence of recent Staphylococcus aureus infection, we studied retrospectively 44 adult patients, gathered between 1979-1990, having an acute arthritis syndrome or an exacerbation in their chronic rheumatic disease and simultaneously a high antistaphylolysin (ASTA > 4,0) and/or high teichoic acid antibody titre (TAA > 8). Patients with septic arthritis or endoprosthetic infections were not included. 25 patients had arthritis/arthralgia associated with a known rheumatic disease, 9 patients had reactive arthritis and 8 patients had arthralgia. The frequency of HLA-B27 in tested patients was significantly higher in the whole patient group than in the healthy Finnish population (43% v 14%, p < 0.001). It is concluded that high ASTA and/or TAA titres are associated with various acute rheumatic syndromes including reactive arthritis.

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“…Antibodies against a-toxin [7,12] have been measured in haemolysin neutralizing tests but the low sensitivity has limited the value of this test. Antibodies against many staphylococcal antigens occur in sera from healthy subjects as well as from patients with infections other than those caused by ;5. aureus [4,5,17,23,24]. Antibodies against many staphylococcal antigens occur in sera from healthy subjects as well as from patients with infections other than those caused by ;5. aureus [4,5,17,23,24].…”

Section: Introductionmentioning

confidence: 99%

Detection of staphylococcus aureus infection by enzyme-linked immunosorbent assay and immunoblotting, using high molecular weight staphylococcal proteins

Rydén¹

1990

FEMS Immunology and Medical Microbiology

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Two high molecular weight staphylococcal proteins, fibronectin‐binding protein and a M 200 000 protein, were investigated as antigens for serodiagnosis of staphylococcal infections. Sera from patients with staphylococcal infections and from controls were subjected to immunoblot analysis with staphylococcal lysate proteins to identify staphylococcal antigens to which patients with staphylococcal infections specifically exhibited antibodies. On such protein was found in the M 200 000 region. This protein was purified and used as antigen in ElISA and compared with other antigens, namely fibronectin‐binding protein(s) (FNBP, M, 185 000), α‐toxin and teichoic acid. Sera from patients with staphylococcal infections contained antibodies to the high molecular weight proteins in higher titers than sera from patients with non‐staphylococcal infections or healthy subjects. Based on their amino‐acid compositions and different abilities to bind fibronectin it was concluded that the M 200 000 protein and FNBP were not identical.

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Occurrence of antibodies to teichoic acid in patients with diseases other than staphylococcal infection

Cited by 9 publications

References 22 publications

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus

Association between high antistaphylolysin and teichoic acid antibody titres with rheumatic syndromes

Detection of staphylococcus aureus infection by enzyme-linked immunosorbent assay and immunoblotting, using high molecular weight staphylococcal proteins

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