Tegretol: A double blind trial in tinnitus

Donaldson, Ivor

doi:10.1017/s0022215100091659

Cited by 36 publications

(27 citation statements)

References 16 publications

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“…Our results were poorer than those ob tained by other authors [4,13,17], The crite rion 'suppression to a non-annoying level' for successful treatment was not used in any of these studies. The use of percentages as a scale for estimation of changes in the com plaint during treatment [4,12,13,17,18] is unreliable.…”

Section: Discussioncontrasting

confidence: 94%

“…Another author [17] who reported a tinnitus-suppressing effect for carbamaze pine recommended that blood levels of 4-8 pg/ml be achieved. The dose given in the present study was about equal to the dosage used in other studies [4,11,13]. In the treat ment of epilepsy, the therapeutic zone is 4-10 pg/ml [14,16].…”

Section: Discussionmentioning

confidence: 76%

“…Recent findings have made it likely that the tinnitus-suppressing effect of lidocaine is localized in the cochlea [10], Although a central anticonvulsive ac tion of lidocaine that suppresses tinnitus is theoretically unlikely, good tinnitus suppres sion by the anticonvulsive drug carbamazepine has been described by some authors [13,17]. According to others, however, carbama zepine is not effective in this respect [4,11],In the present study, the value of carba mazepine in the treatment of tinnitus was assessed in a double-blind controlled trial. The effect on tinnitus and the side effects are discussed.…”

mentioning

confidence: 99%

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The Value of Carbamazepine in the Treatment of Tinnitus

Hulshof¹,

Vermeij

1985

ORL

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

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The Value of Carbamazepine in the Treatment of Tinnitus

Hulshof¹,

Vermeij

1985

ORL

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“…Our report has described a distinct tinnitus syndrome responsive to carbamazepine despite well-designed prior studies showing no benefi t of carbamazepine for tinnitus subjects [11][12][13] . The failure of the prior studies to detect this effect is probably due to its infrequent occurrence.…”

Section: Discussioncontrasting

confidence: 56%

Typewriter Tinnitus: A Carbamazepine-Responsive Syndrome Related to Auditory Nerve Vascular Compression

Levine

2006

ORL

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Six subjects with similar unilateral tinnitus that was fully suppressed by carbamazepine have been identified. Their ages at the time of the sudden onset of their tinnitus ranged from 39 to 87 years (mean 67). The 3 men had right ear tinnitus. Two of the 3 women had left ear tinnitus. All 6 described a staccato quality of their intermittent tinnitus (‘like a typewriter in the background, pop corn, Morse code’). Five of the 6 subjects had no other hearing or vestibular complaints; their audiograms were symmetric and consistent with their ages. Vascular compression of the auditory nerve ipsilateral to the tinnitus was detected in 4 of the 5 subjects imaged. The similarities between typewriter tinnitus and other cranial nerve syndromes associated with vascular compression (trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia) suggest that surgical decompression of the auditory nerve can relieve medication-refractive cases of typewriter tinnitus.

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“…69 Antispasmodic drugs 70 and drugs for neuropathic pain 71 are generally ineff ective, although one trial showed a possible small eff ect of gabapentin in a subgroup of patients with tinnitus secondary to acoustic trauma. 72 Several anticonvulsant drugs have been tested, including amino-oxyacetic acid, 73 lamotrigine, 74 and carbamazepine, 75 without success. Glutamate is the main excitatory neurotransmitter in the auditory system; consequently, various antagonist drugs have been investigated.…”

Section: Drug Treatmentsmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,027

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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Tegretol: A double blind trial in tinnitus

Cited by 36 publications

References 16 publications

The Value of Carbamazepine in the Treatment of Tinnitus

The Value of Carbamazepine in the Treatment of Tinnitus

Typewriter Tinnitus: A Carbamazepine-Responsive Syndrome Related to Auditory Nerve Vascular Compression

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