Technological Potential of Antimicrobial Peptides: a Systematic Review

Abstract

Machado et al.: Review of Antimicrobial Peptides Resistance to antibiotics has being considered one of the greatest public health problems worldwide. The objective of this systematic review was to compile important bibliographical references that support the studies related to the biotechnological potential of antimicrobial peptides. Antimicrobial peptides are considered the major components of the innate immune system and work in defence against infections caused by different microorganisms. Many researchers argue that the studies associated with the discoveries of antimicrobial peptides that are more effective in the treatment of infections caused by microorganisms be also directed to the substances produced by insects. The major aspects associated to the technological potential of antimicrobial peptides are, general characteristics, classification, mode of action and prospects for applying, mainly in the pharmaceutical industry. It can be concluded that research for new substances with action against pathogenic microorganisms aim mainly to seek alternatives to the use of antibiotics. In addition, anticancer peptides are small cationic molecules with promising pharmacological use. However, the products for application in the protection of food, treatment of skin infections and its use in the cosmetics industry are those with the greatest potential.

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Insect antimicrobial peptides: isolation, separation and antimicrobial activity

“…In addition, in vivo AMPs of different classes and various antimicrobial substances have a synergistic antimicrobial effect [5]. According to some studies, the development of resistance in microorganisms to antimicrobial peptides in vitro is unlikely [6].…”

Augmenting Bioactive Metabolite Synthesis from Streptomyces Species Isolated from Mangrove Sediments through Physio-Chemical Parameters

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