A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy

Abstract

Resveratrol is a polyphenolic antioxidant whose possible health benefits include anticarcinogenic, antiaging, and antimicrobial properties that have gained significant attention. The compound is well accepted by individuals and has been commonly used as a nutraceutical in recent decades. Its widespread usage makes it essential to study as a single agent as well as in combination with traditional prescription antibiotics as regards to antimicrobial properties. Resveratrol demonstrates the action of antimicrobials against a remarkable bacterial diversity, viruses, and fungus. This report explains resveratrol as an all-natural antimicrobial representative. It may modify the bacterial virulence qualities resulting in decreased toxic substance production, biofilm inhibition, motility reduction, and quorum sensing disturbance. Moreover, in conjunction with standard antibiotics, resveratrol improves aminoglycoside efficacy versus Staphylococcus aureus, while it antagonizes the deadly function of fluoroquinolones against S. aureus and also Escherichia coli. The present study aimed to thoroughly review and study the antimicrobial potency of resveratrol, expected to help researchers pave the way for solving antimicrobial resistance.

Solid Dispersions Incorporated into PVP Films for the Controlled Release of Trans-Resveratrol: Development, Physicochemical and In Vitro Characterizations and In Vivo Cutaneous Anti-Inflammatory Evaluation

“…Trans-resveratrol can diminish the production of biofilms and toxins and reduce this bacteria's motility. It also avoids the production of exotoxins (including the staphylococcal enterotoxin A) that can activate the immune response of T lymphocytes, which produce immunoglobulin E, increasing irritation and inflammation, and aggravating the clinical condition [66,73].…”

Chemistry and Bioactivity of Microsorum scolopendria (Polypodiaceae): Antioxidant Effects on an Epithelial Damage Model

“…These results may be attributed to the relative abundance of polyphenols such as isoxanthohumol, resveratrol, and kaempferide [ 51 , 52 ]. These types of compounds have been shown to have the ability to inhibit biofilm formation by downregulating the expression of genes such as rsbU and spa, which are genes responsible for bacterial adhesion, communication, and bacterial protection [ 53 , 54 , 55 ]. The extract that showed more significant inhibition of biofilm formation was RAE at 128 µg/mL against S. epidermidis .…”

The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review

“…In recent years, resveratrol has been extensively studied for its effects on human pathogens. Many studies have shown the antimicrobial activity of resveratrol against a wide range of bacteria, viruses, and fungi [54]. Interestingly, it was demonstrated that resveratrol is able to inhibit replication of human herpes viruses [55], influenza viruses [56], and Epstein-Barr virus [57,58].…”