“…Their results demonstrate that their formulation can enhance the bioavailability of celecoxib which is hydrophobic. Another study evaluates PVP to form a film with an anti-inflammatory Trans -resveratrol drug and the result shows that this formulation can decrease the inflammation in vivo by approximately 66 % ( Riccio et al, 2022 ). In addition, several other studies demonstrated a lack of toxicity of PVP owing to its biologically inertness ( Wessel et al, 1971 , Nair, 1998 ).…”