Techniques of tumour bed boost irradiation in breast conserving therapy: Current evidence and suggested guidelines

Jalali, Rakesh; Singh, Suruchi; Budrukkar, Ashwini

doi:10.1080/02841860701441798

Cited by 42 publications

(24 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[19,20] Additional risk factors for local recurrence can be big tumor size, close A number of trials have studied and compared the different boost modalities in the past, electrons and interstitial implant boost being the standard among them. [21] In case of boost with electrons, fields defined on the basis of clinical details and scar have been found to be erroneous in several studies. [22,23] Hence, the dimensions as well as depth for tumor bed boost should be determined either by fluoroscopy or CT combined with surgical clips, or an ultrasound.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and cosmetic results of breast boost radiotherapy in early breast cancer: A randomized study between electron and photon

et al. 2014

View full text Add to dashboard Cite

Both electrons and 3DCRT can be used for boost planning to the tumor bed in post-lumpectomy patients. Though there was slightly increased acute skin toxicity with 3DCRT photon which led to interruption of therapy, overall cosmesis at 2 years is similar in both modalities. 3DCRT boost is a better option than electrons dosimetrically, considering the fact that conformality; PTV coverage and OAR dosimetry were superior with photons. Thus in centers where electron beam therapy is not available, 3DCRT photon can be used effectively for tumor bed boost.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[25] Interstitial implant is an invasive procedure associated with pain, is technically challenging and is not universally available in community settings. [21,25] The overall cosmesis is commonly compromised with formation of scars at the entry and exit sites of interstitial needles or tubes.…”

Section: Discussionmentioning

confidence: 99%

Clinical and cosmetic results of breast boost radiotherapy in early breast cancer: A randomized study between electron and photon

et al. 2014

View full text Add to dashboard Cite

show abstract

“…[1,2] Radiotherapy (RT) to whole breast followed by tumor bed boost is the standard adjuvant treatment option after breast conserving surgery (BCS). [3] RT after breast conservation in developed countries is usually done by linear accelerators (LA). [4] It is a well-known fact of physics that patients treated with cobalt have higher skin and subcutaneous dose.…”

Section: Introductionmentioning

confidence: 99%

Impact of adjuvant radiation therapy photon energy on quality of life after breast conservation therapy: Linear accelerator versus the cobalt machine

et al. 2012

Self Cite

View full text Add to dashboard Cite

There is no significant difference in QOL domains between appropriately selected patients treated with cobalt and LA. There are no significant changes in QOL domain scores at RT conclusion as compared to pre-RT baseline in patients treated with cobalt or LA source. A cobalt machine may be effectively used to deliver adjuvant RT in appropriately selected BCT patients especially in developing countries with limited resources.

show abstract

“…2–4 Following BCS, some form of localized postoperative therapy such as radiation (RT), chemotherapy, or both is used in the hope of eliminating any remaining malignant cells. 5–9 The use of ionizing RT, though effective, has several limitations, as does the dose-limiting toxicity of many of the chemotherapeutic agents in use as postoperative therapy. 10–14 In this study we investigated the ability of a light-based approach known as photochemical internalization (PCI) to increase the local efficacy of cisplatin (CP) and one of its analogs, dichloro(4,4′-dipropyl-2,2′-bipyridine) platinum (DP) on several breast tumor cell lines in vitro.…”

Section: Introductionmentioning

confidence: 99%

Photochemical Internalization-Mediated Delivery of Chemotherapeutic Agents in Human Breast Tumor Cell Lines

Mathews

Shih

et al. 2012

J Environ Pathol Toxicol Oncol

View full text Add to dashboard Cite

Breast-conservation surgery (BCS) is now utilized in patients with stage I and II invasive breast cancer. However, positive surgical margins are associated with recurrence, and therefore some form of localized postoperative therapy (radiation/chemotherapy) is necessary to eliminate remaining cancer cells. Existing modalities have significant treatment-limiting side effects; therefore, alternative forms of localized therapy need to be explored. We studied the ex vivo effects of photochemical internalization (PCI) using 4 chemotherapeutic agents: cisplatin, cisplatin analog [D prostanoid, DP], doxorubicin, and bleomycin) on 3 breast cancer cell lines: MCF-7, MDA-MB-435, and MDA-MB-231. Illumination was carried out using a 670-nm diode laser at 5 mW/cm2 following incubation in the photosensitizer with aluminum phthalocyanine disulfonate. Toxicity was investigated using colony-forming assays and the mechanism of cell death was determined using Annexin flow-cytometry. We found that toxicity of DP and bleomycin was significantly enhanced by PCI compared with drug alone but was unchanged for cisplatin and doxorubicin. PCI treatment caused a decrease in the percentage of viable cells, predominantly by enhancing apoptosis. The action was synergistic across all 3 cell lines tested for DP and bleomycin. Thus, with appropriate delivery devices and choice of chemotherapeutic agents, PCI holds the promise of enhancing tumor cell toxicity surrounding the cavity of BCS resection sites and thereby decreasing local recurrence.

show abstract

Techniques of tumour bed boost irradiation in breast conserving therapy: Current evidence and suggested guidelines

Cited by 42 publications

References 83 publications

Clinical and cosmetic results of breast boost radiotherapy in early breast cancer: A randomized study between electron and photon

Clinical and cosmetic results of breast boost radiotherapy in early breast cancer: A randomized study between electron and photon

Impact of adjuvant radiation therapy photon energy on quality of life after breast conservation therapy: Linear accelerator versus the cobalt machine

Photochemical Internalization-Mediated Delivery of Chemotherapeutic Agents in Human Breast Tumor Cell Lines

Contact Info

Product

Resources

About