Abstract:The optimal composition and production technique were identified for preparation of liposomal formulations of lisomustine. The stability of this formulation was increased by lyophilization of the liposomal dispersion using a cryoprotector, i.e., 10% sucrose solution. The lisomustine content in lysosomes was assayed by spectrophotometry at a wavelength of 230 nm. Uptake of lisomustine into freshly prepared liposomes amounted to 61.2 ± 0.4% and particle size was 170 ± 20 nm.
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