Technical and Alarm signs for referral in adult patients with acute febrile illness: A study from a tertiary care hospital in North India

Gupta, Nitin; Mittal, Ankit; Kutty, Sharada V; Kumar, Arvind; Wig, Naveet

doi:10.4103/jfmpc.jfmpc_138_18

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…There is not much data which reveal how CHIKV infection affects the kidneys, but what little clinical evidence exists shows that CHIKV can cause acute kidney injury (AKI), usually if rhabdomyolysis, acute interstitial nephritis, thrombotic microangiopathy, or a renal lesion is already present [97][98][99]. Furthermore, kidney disease, as a pre-existing condition, can be exacerbated, resulting in worse symptoms of infection, hospitalization, or death [99][100][101][102]. Unfortunately, due to the lack of data, not many conclusions can be made about the immunological response to CHIKV infection in the renal system.…”

Section: Potential Renal Complications and Concerns For Organ Transpl...mentioning

confidence: 99%

Chikungunya Immunopathology as It Presents in Different Organ Systems

Traverse

Millsapps

Underwood

et al. 2022

Viruses

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Chikungunya virus (CHIKV) is currently an urgent public health problem as high morbidity from the virus leaves populations with negative physical, social, and economic impacts. CHIKV has the potential to affect every organ of an individual, leaving patients with lifelong impairments which negatively affect their quality of life. In this review, we show the importance of CHIKV in research and public health by demonstrating the immunopathology of CHIKV as it presents in different organ systems. Papers used in this review were found on PubMed, using “chikungunya and [relevant organ system]”. There is a significant inflammatory response during CHIKV infection which affects several organ systems, such as the brain, heart, lungs, kidneys, skin, and joints, and the immune response to CHIKV in each organ system is unique. Whilst there is clinical evidence to suggest that serious complications can occur, there is ultimately a lack of understanding of how CHIKV can affect different organ systems. It is important for clinicians to understand the risks to their patients.

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Section: Potential Renal Complications and Concerns For Organ Transpl...mentioning

confidence: 99%

Chikungunya Immunopathology as It Presents in Different Organ Systems

Traverse

Millsapps

Underwood

et al. 2022

Viruses

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A diagnostic randomised controlled trial to study the impact of rapid diagnostic tests in patients with Acute febrile illness when compared to conventional diagnostics (DRACO study)

Gupta

Joylin

Ravindra

et al. 2021

Journal of Infection

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Chikungunya Death Risk Factors in Brazil, in 2017: A case-control study

et al. 2022

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Background In 2016/2017 we had a major epidemic of chikungunya (CHIK) in Brazil, with many deaths. We evaluated to factors associated with deaths from CHIK that occurred in the city of Fortaleza, Brazil. Methods A matched case-control study was conducted (1:2), by sex, age (± 5 years) and neighborhood. Cases were CHIK deaths that occurred between January 1 and December 31, 2017, in Fortaleza, Brazil, and which were laboratory confirmed. Controls were laboratory confirmed CHIK patients occurring in the same neighborhood and in the same period, but which did not progress to death. Results 82 cases of CHIK and 164 controls were included. Considering the clinical history, significant associations were found between other chronic heart diseases (OR 3.8; CI: 1.53–9.26) and chronic kidney disease (OR 12.77; CI: 2.75–59.4). In the multivariate analysis of the variables related to signs and symptoms, fever (OR: 19.23 CI: 1.73–213.78), abdominal pain (OR: 3; 74 CI: 1.06–13.16), apathy (OR: 11.62 CI: 2.95–45.82) and dyspnea (OR: 50.61; CI: 12.37–207.18) were identified with greater likelihood of death from CHIK. It also stood out that altered blood glucose was associated with cases with a worse prognosis (OR: 13.5; CI: 1.3–135.0). Among the laboratory findings, only lymphocytes and albumin were not associated with greater likelihood of death. Conclusion The factors related with deaths were chronic kidney disease and previous heart disease, presence of fever, abdominal pain, apathy, dyspnea and arthritis and laboratory findings such as leukocytosis, leukopenia, thrombocytopenia, neutropenia and lymphopenia.

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Technical and Alarm signs for referral in adult patients with acute febrile illness: A study from a tertiary care hospital in North India

Cited by 4 publications

References 13 publications

Chikungunya Immunopathology as It Presents in Different Organ Systems

Chikungunya Immunopathology as It Presents in Different Organ Systems

A diagnostic randomised controlled trial to study the impact of rapid diagnostic tests in patients with Acute febrile illness when compared to conventional diagnostics (DRACO study)

Chikungunya Death Risk Factors in Brazil, in 2017: A case-control study

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