Tear Osmolarity and Ocular Surface Changes in Patient with Polycystic Ovary Syndrome

Gönen, Tansu; Çelik, Cem; Öznur, Meltem; Abalı, Remzi; Gönen, Korcan Aysun; Horozoğlu, Fatih; Aksu, Erson; Keskinbora, Kadircan

doi:10.3109/02713683.2012.749917

Cited by 27 publications

(18 citation statements)

References 18 publications

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“…Particularly in these women there is a significant increase in signs and symptoms of DE. Not surprisingly, a high incidence of evaporative DE disease was found in hyperandrogenic women affected by syndrome of polycystic ovarian syndrome [40,41]. This allows us to speculate that for the tear film to be stable it is necessary a perfect balance between androgens and estrogens for a normal function [40,41].…”

Section: Hormonal Changesmentioning

confidence: 91%

“…Androgens are steroid hormones that are produced by the adrenals (dehydroepiandrosterone demonstrated that androgen levels are essential for normal lacrimal gland function and structural organization and that prolactin and estrogens also play important roles in providing an adeguate hormone provision for optimal lacrimal production [39][40][41]. In particular, the androgen receptor influence the MGs, this has led to the hypothesis that these glands are under hormonal control.…”

Section: Hormonal Changesmentioning

confidence: 99%

“…This reduction has been attributed to a significant fall in the conversion of androstenedione to testosterone after the menopause [39,40]. The data suggest that sex hormone deficiency can not only cause a reduction in the production of aqueous tears leading to a deficiency but also to a dysfunction in the MG function resulting in an evaporative DE.…”

Section: Hormonal Changesmentioning

confidence: 99%

“…The data suggest that sex hormone deficiency can not only cause a reduction in the production of aqueous tears leading to a deficiency but also to a dysfunction in the MG function resulting in an evaporative DE. In women with complete androgen insensitivity syndrome due to androgen receptor dysfunction, an alteration in neutral and polar lipid patterns of human MG secretion along with a keratinisation of the MG ductal epithelium (ie, orifice metaplasia) and the lid has been observed [38][39][40][41]. Particularly in these women there is a significant increase in signs and symptoms of DE.…”

Section: Hormonal Changesmentioning

confidence: 99%

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Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Nebbioso¹,

Regno²,

Gharbiya³

et al. 2017

Preprint

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The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome, because the tear film represents the interface between the eye and the environment. Despite having a multifactorial origin, the main risk factors for the emergence of the ocular disease are female gender and advanced age. Peer-reviewed version available at Int. J. Mol. Sci. 2017, 18, 1764 doi:10.3390/ijms18081764 2 Likewise, morphological changes in several glands and in chemical composition of their secretions such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors to maintain a condition of good health of the ocular anterior segment. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic infiammation that reflex on the ocular surface. However, it is one of the most commonly encountered disease in clinical practice and many other causes related to daily life and to lengthen the average life will contribute to the beginning. This review will consider how and what disorders of the ocular surface are responsible for a widespread pathology so. In the end, the most appropriate and new therapies will be briefly exposed according to the specific pathology.

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Section: Hormonal Changesmentioning

confidence: 91%

Section: Hormonal Changesmentioning

confidence: 99%

Section: Hormonal Changesmentioning

confidence: 99%

Section: Hormonal Changesmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Nebbioso¹,

Regno²,

Gharbiya³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…M aters et al reported a negative correlation betw een total testosterone and tear function in prem enopausal w om en, w hereas total testosterone correlated positively w ith tear function for w om en in m enopause (25) . O ne recent study, G onen et al (26) evaluated tear osm olarity test. T his study reported that there w as no significant difference betw een the m ean tear osm olarity values obtained from P (26) .…”

Section: Discussionmentioning

confidence: 99%

Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome

Guliyev¹,

Çabuk²,

Kirgiz³

et al. 2016

Revista Brasileira De Oftalmologia

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P urpose: P olycystic ovary syndrom e (P C O S) is an endocrine disease characterized by chronic anovulation and hyperandrogenism . H orm onal changes can affect tear function. T his study evaluates tear function and im pact of hyperandrogenism on it in P C O S patients. M ethods: F ifty patients w ith P C O S and thirty control volunteers w ere exam ined for tear break-up tim e, Schirm er-I and tear osm olarity. A lso, serum levels of total testosterone, F SH , L H and A M H w ere determ ined in venous blood sam ples in the early follicular phase. P C O S patients w ere divided into tw o groups by plasm a total testosterone level: G roup A w ith norm al (0.513 ng/m l;n= 27), G roup B w ith higher horm one level (> 0.513 ng/m l;n= 23). H ealthy control group indicated as G roup C (n= 30). R esults: L H , total testosterone levels w ere higher in the P C O S group than in the control group (p= 0.012;p= 0.025). M ean values of tear break-up tim e and Schirm er-I w ere different betw een groups and especially G roup A and C w ere near to each other differing from B (p> 0.05). Tear osm olarity results w ere higher in G roup B , com pared to A and C (p= 0.049;p= 0.033). N o significant difference detected in tear osm olarity value m eans of G roup A and C (p= 0.107). A M H levels w ere higher in G roup B , com pared to A and C (p= 0.002;p= 0.001). A M H levels in G roup A w ere higher than that of C (p= 0.002). P ositive correlation betw een levels of total testosterone and A M H w as detected in all P C O S patients (n=. U m a correlação positiva entre os níveis de testosterona total e A M H foi detectada em todas as pacientes com SO P (n = 50;P earson's r = 0,579; p < 0,001). C onclusão: a função lacrim al pode ser afetada em pacientes com SO P com hiperandrogenism o. A osm olaridade lacrim al é o m étodo de avaliação m ais sensível e objetivo para alterações da superfície ocular em SO P. D escritores: Síndrom e dos ovários policísticos; L ágrim as / fisiologia; C oncentração osm olar; H iperandrogenism o; H orm ônio anti-m ülleriano

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Cornea in PCOS patients as a possible target of IGF-1 action and insulin resistance

Kebapçılar

Tatar

İpekçi

et al. 2014

Arch Gynecol Obstet

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These findings indicate that PCOS has target organ effects on the eye. Consequently, it can change central corneal thickness. Higher IGF-1 levels seem to be the main causes of increased corneal thickness. Insulin resistance in PCOS is one of the underlying causes and promotes increase in IGF-1. We suggest a careful and detailed corneal evaluation in PCOS patients to prevent the potential risk of increased CCT, in addition to the already-known complications.

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Tear Osmolarity and Ocular Surface Changes in Patient with Polycystic Ovary Syndrome

Abstract: In patients with recently diagnosed PCOS, tear volume and osmolarity are not affected but, conjunctival morphology may be affected, though on a limited scale.

Cited by 27 publications

References 18 publications

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome

Cornea in PCOS patients as a possible target of IGF-1 action and insulin resistance

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