Tear function and goblet cell density after pterygium excision

Li, M; Zhang, M; Lin, Ying; Xiao, Qing; Zhu, Xiaomin; Song, Seung Yeon; Lin, Jingyi; Chen, J; Liu, Z

doi:10.1038/sj.eye.6702186

Cited by 50 publications

(48 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tear osmolarity, however, deteriorated after 12 months in cases of pterygium recurrence. The authors inferred that pterygium excision improves tear film function, supporting similar findings of two previous studies [23,24], and concluded that pterygium recurrence leads to dry eye.…”

Section: Discussionsupporting

confidence: 82%

Dry-Eye Disease in Recurrent Pterygium

Tan

Vollmer‐Conna

Tat³

et al. 2018

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: The aim of this paper was to investigate the degree of inflammation and dry-eye disease (DED) in recurrent pterygium. Methods: Fifty-five patients with a history of pterygium excision were divided into 3 groups – Group 1: no recurrence after the first excision; Group 2: recurrence after the first excision; Group 3: no recurrence after the second excision. Dry-eye symptoms and tear production were elicited for each patient. Results: A high prevalence of DED was observed in patients with primary and recurrent pterygium based on self-reported dry-eye symptoms (63.6%) and an abnormal Schirmer test result (78.1%). There was a statistically significant difference (p = 0.025) in the Schirmer test values between patients with (5.6 mm) and without (11.4 mm) recurrence after surgery for primary pterygium. Patients who were cured after a second excision had an improved Schirmer test value (9.5 mm), although this was not significant. Conclusion: Pterygium recurrence is associated with a greater severity of dry eye, possibly by perpetuating ocular surface inflammation in the postoperative period.

show abstract

Section: Discussionsupporting

confidence: 82%

Dry-Eye Disease in Recurrent Pterygium

Tan

Vollmer‐Conna

Tat³

et al. 2018

Ophthalmic Res

View full text Add to dashboard Cite

show abstract

“…But the Schirmer test still showed no significant difference. Li et al [14] have shown similar results. In their study, 70 eyes (70 patients) were enrolled and underwent a bare-sclera procedure.…”

Section: Discussionmentioning

confidence: 56%

“…The results of the MFT showed that the ratio of normal crystallization in the affected eyes was significantly increased 4 and 8 weeks after the operation, which coincided with BUT. We could conclude from our results that once formed, pterygium itself leads to abnormal tear film function [14] . Pterygium excision combined with limbalconjunctival autograft transplantation can partially restore the tear functions into normal state in the affected eyes.…”

Section: Discussionmentioning

confidence: 57%

“…A previous smallscale study has investigated the effects of pterygium excision using the limbal-conjunctival autografting technique on the tear function tests in 14 eyes of 13 patients, but no difference was found in the Schirmer and BUT tests at 1 and 6 months after compared to before surgery [13] . However, a recent study found that tear function in patients with primary pterygium improved 1 month after pterygium excision [14] . The 2 studies produced conflicting results.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Changes of Tear Film Function after Pterygium Operation

Wang

Jiang

2010

Ophthalmic Res

View full text Add to dashboard Cite

Objective: To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. Methods: Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the patients before and after pterygium excision combined with limbal-conjunctival autograft transplantation. Results: Compared with the opposite healthy eyes, the BUT and MFT in the eyes with pterygium were significantly different before the operation (p < 0.05); however, there was no significant difference in the results of the Schirmer test (p > 0.05). The results of the BUT and MFT in the eyes with pterygium were significantly different before and 4 weeks after the operation (p < 0.05). The BUT was prolonged from 9.89 ± 3.95 to 12.78 ± 4.12 s, and the ratio of normal crystallization in the MFT increased from 46.7 to 80.0%. There was no significant difference in the Schirmer test results before and after the operation (p > 0.05). Conclusion: Tear functions were abnormal in the eyes with pterygium. Pterygium excision combined with limbal-conjunctival autograft transplantation can partially restore the tear film function into normal state, and the tear film function was stable 4 weeks after surgery.

show abstract

“…Finally, it develops a vicious circle in which the tear hyperosmolarity same stimulates the expression of MMP and leads to inflammation of the ocular surface [71]. A study shows that excision of pterygium improves the osmolarity and function of the tear film, bringing an improvement of the tear BUT and ferning tests, due to increase in density of conjunctival GCs and lacrimal mucous component [72]. However, the tear osmolarity remains stable for the time in which no pterygium recurrence.…”

Section: Pterygiummentioning

confidence: 99%

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Nebbioso¹,

Regno²,

Gharbiya³

et al. 2017

Preprint

View full text Add to dashboard Cite

The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome, because the tear film represents the interface between the eye and the environment. Despite having a multifactorial origin, the main risk factors for the emergence of the ocular disease are female gender and advanced age. Peer-reviewed version available at Int. J. Mol. Sci. 2017, 18, 1764 doi:10.3390/ijms18081764 2 Likewise, morphological changes in several glands and in chemical composition of their secretions such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors to maintain a condition of good health of the ocular anterior segment. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic infiammation that reflex on the ocular surface. However, it is one of the most commonly encountered disease in clinical practice and many other causes related to daily life and to lengthen the average life will contribute to the beginning. This review will consider how and what disorders of the ocular surface are responsible for a widespread pathology so. In the end, the most appropriate and new therapies will be briefly exposed according to the specific pathology.

show abstract

Tear function and goblet cell density after pterygium excision

Cited by 50 publications

References 19 publications

Dry-Eye Disease in Recurrent Pterygium

Dry-Eye Disease in Recurrent Pterygium

Changes of Tear Film Function after Pterygium Operation

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Contact Info

Product

Resources

About