Tear and serum vitamin D levels in children with allergic rhinoconjunctivitis

Göksügür, Sevil Bilir; Erdurmuş, Mesut; Bekdaş, Mervan; Erkoçoğlu, Mustafa; Ağca, Sümeyra; Tosun, Mehmet; Göksügür, Nadir; Demircioğlu, Fatih

doi:10.1016/j.aller.2014.10.004

Cited by 17 publications

(15 citation statements)

References 18 publications

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“…The present data show that the serum levels of VitD3 are significantly lower in AR patients than that in healthy controls. Similar condition was also reported by others in AR patients , allergic conjunctivitis , and asthma . Besides allergic disorders, VitD3 abnormality was also found associating with rheumatoid arthritis , diabetes , and cancer .…”

Section: Discussionsupporting

confidence: 89%

Vitamin D regulates immunoglobulin mucin domain molecule‐4 expression in dendritic cells

Liu

Geng

et al. 2017

Clin Experimental Allergy

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Section: Discussionsupporting

confidence: 89%

Vitamin D regulates immunoglobulin mucin domain molecule‐4 expression in dendritic cells

Liu

Geng

et al. 2017

Clin Experimental Allergy

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“…In the current study, we have shown that 25-hydroxyvitamin D can be measured in human tears by competitive chemiluminescent immunoassay and that the 25-hydroxyvitamin D levels were significantly higher in the tears than in the serum. Similarly, another study reported significantly higher 25-hydroxyvitamin D levels in tears (71.8 ± 6.2 ng/ml) compared to serum (21.8 ± 11.3 ng/ml) in children (12.5 ± 2.5 years) using electro chemiluminescent immunoassay [22]. The difference in the 25-hydroxyvitamin D levels between tear fluid and serum seem to vary between the current study and that reported by Goksugur SB et al The primary reason underlying this difference could be related to the principle and sensitivity of the assay used to measure 25-hydroxyvitamin D [23, 24].…”

Section: Discussionmentioning

confidence: 98%

Correlation between tear fluid and serum vitamin D levels

et al. 2016

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Background: Vitamin D deficiency is associated with a range of systemic diseases including ocular disorders. The objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D levels. Methods: A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort study. Serum was collected using clot activator coated Vacutainer® Plus tubes. Tear fluid was collected using Schirmer's strips. Serum and tear total 25-hydroxyvitamin D levels were measured by competitive chemiluminescent ELISA and the correlation between the levels were studied. Results: The measured serum 25-hydroxyvitamin D level ranged between 3.3 and 27.5 ng/ml (Mean ± SEM, 9.4 ± 0. 7 ng/ml; Median 8.4 ng/ml). Significantly (p < 0.0001) higher level of 25-hydroxyvitamin D was detected in the tears (Mean ± SEM, 17.0 ± 1.6 ng/ml; Range 3.2-45.8 ng/ml; Median, 16.3 ng/ml) compared to serum. An average of~2 fold (Mean ± SEM, 1.9 ± 0.2; Range 0.4-5.8; Median, 1.7) higher 25-hydroxyvitamin D was observed in tears compared to serum in the subjects. In addition, a positive correlation was observed between serum and tear 25-hydroxyvitamin D levels (r = 0.5595; p < 0.0001). Conclusions: A higher level of 25-hydroxyvitamin D was observed in the tear fluid compared to that of the serum. It would be beneficial to consider tear vitamin D levels to study its role with reference to ocular surface diseases.

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“…In a study it was found that the 25-hydroxyvitamin D level was significantly higher in the tears than in the serum [18]. Also in, another study reported significantly higher 25-hydroxyvitamin D levels in tears (71.8 ± 6.2 ng/ml) compared to serum (21.8 ± 11.3 ng/ml) in children (12.5 ± 2.5 years) using electro chemiluminescent immunoassay [19]. .…”

Section: Discussionmentioning

confidence: 95%

Role of Vitamin D in Endothelial Cell of Retina

Jindal¹,

Taneja²

2019

IJMBS

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Vitamin D deficiency is a common health problem worldwide. Many parts of the human eye, including the epithelium of the cornea, lens, ciliary body, and retinal pigment epithelium, as well as the corneal endothelium, ganglion cell layer, and retinal photoreceptors, contain vitamin D receptor. Physiological effects of vitamin D From an ocular point of view, the role in macular and retinal health had been advanced, as well as the involvement in corneal inflammatory response, wound healing, and dry eye disease. The most important effect of vitamin D is on, phosphorus, calcium metabolism and on bone mineralization. Recently, it was observed that vitamin D deficiency and insufficiency are related with common cancers, cardiovascular diseases, metabolic syndromes, infectious, and many chronic diseases including autoimmune disease. Benefits of vitamin D may be amplified through synergistic interaction with topical corticosteroids which accelerates improvement in corneal shape and optics, substantially benefiting the control of ocular surface disease and dry eye symptoms. Aqueous humour is the primary source responsible for the feeding of corneal endothelial layer hence endothelial abnormalities can be expected due to accumulated inflammatory cytokines and multiple toxic products in the aqueous humour of the patients with vitamin D deficiency. MATERIAL AND METHODS: Subjects were selected with vitamin D deficiency in the age group of 20–55 years. 50 patients having serum vitamin D levels <15 ng/ml were included in the study. Serum vitamin D levels of <15 ng/ml were included in the control group. Vitamin D levels in tear fluid were measured by direct competitive chemiluminescent enzyme linked immunoassay. A complete ophthalmic evaluation was performed in all participants which includes assessment of visual acuity, anterior segment evaluation and posterior segment evaluation. Specular microscopy was performed on the eyes of the patients with vitamin D deficiency and healthy control group individuals. Corneal endothelial cell density (CD) and central corneal thickness (CCT) values were calculated automatically using the software of the specular microscope. RESULTS: The study group included 23 male and 27 female subjects while study group included 24 male and 26 female. Mean age of male in study group was 46.4 ± 12.56 and female was 45.6 ± 11.77. In control group mean male age was 48.5 ± 9.25 and female age was 49.56 ± 12.55. In study group Mean Corneal endothelial cell density (CD) was observed as 2632.89 ± 189.25 cells/mm 2 and Mean central corneal thickness (CCT) was 587.2 ± 25.89 μ. In control group Mean Corneal endothelial cell density (CD) was observed as 2954.97 ± 116.89 cells/mm 2 and Mean central corneal thickness (CCT) was 546.0 ± 36.22 μ. Vitamin D levels of Tears in study group was 8.4 ± 1.7 ng/ml and in control group it was 16.2 ± 2.3 ng/ml. CONCLUSION: It has been observed that there is statistically significant difference in the corneal endothelial cell density (CD) and central corneal thickness (CCT) in patients with vitamin D deficiency. It was observed that Vitamin D is present in tear fluid and there is significant difference in the levels of vitamin D in study and control group.

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Tear and serum vitamin D levels in children with allergic rhinoconjunctivitis

Cited by 17 publications

References 18 publications

Vitamin D regulates immunoglobulin mucin domain molecule‐4 expression in dendritic cells

Vitamin D regulates immunoglobulin mucin domain molecule‐4 expression in dendritic cells

Correlation between tear fluid and serum vitamin D levels

Role of Vitamin D in Endothelial Cell of Retina

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