TEAD2 as a novel prognostic factor for hepatocellular carcinoma

Joo, Jong Seok; Cho, Sang Yeon; Rou, Woo Sun; Kim, Ju Seok; Kang, Sun Hyung; Lee, Eaum Seok; Moon, Hee Seok; Kim, Seok Hyun; Sung, Jae Kyu; Kwon, In Sun; Eun, Hyuk Soo; Lee, Byung Seok

doi:10.3892/or.2020.7578

Cited by 18 publications

(14 citation statements)

References 42 publications

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“…Previous studies showed that the expression of TEAD2 was enriched in the nucleus and directed a predominant nuclear localization of YAP via the formation of TEAD2-YAP complex in the process of epithelial-mesenchymal transition of breast cancer cells [28]. Besides, the expression of TEAD2 is associated with a poor prognosis in hepatocellular carcinoma patients, which can be considered as a therapeutic target of hepatocellular carcinoma [30]. However, there are little data about the effects of TEAD2 in GC.…”

Section: Discussionmentioning

confidence: 99%

TEADs serve as potential prognostic biomarkers and targets for human gastric cancer

et al. 2022

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TEADs are critical transcription factors that participate in the Hippo pathway. Evidence indicates the promotion role of TEADs in cancer progression. However, the role of TEADs and the expression patterns in gastric cancer remains unclear. In this study, we evaluated the expression levels of TEADs in gastric cancer samples, and the clinical outcomes of patients with high TEADs expression were observed. Co-expression and interaction analysis as well as functional enrichment analysis were further conducted to determine the potential role of TEADs in gastric cancer. These results suggested TEADs may serve as the prognostic biomarkers or therapeutic targets for gastric cancer. However, more studies are warranted to verify our findings and promote the application in gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%

TEADs serve as potential prognostic biomarkers and targets for human gastric cancer

et al. 2022

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“…24,25 TEAD2 was significantly upregulated in hepatocellular carcinoma (HCC) and the higher expression was associated with poor OS time of HCC. 26,27 In addition, TEAD3 could promote the proliferation of gastric cancer cell line MKN-28 through increasing SLC35B4 expression. 28,29 Abnormally expressed TEAD4 could obviously cause epithelial-to-mesenchymal transition (EMT) in colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma

Ren

Wang

Peng

et al. 2021

IJGM

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Purpose: To explore the molecular profiles of transcriptional enhanced associate domain (TEAD) family in ovarian serous carcinoma (OSC). Methods: In this study, we use bioinformatics methods including GEPIA, GE-mini, Oncomine 3.0, Kaplan-Meier plotter, cBioPortal, WebGestalt, TIMER2.0 and DiseaseMeth2.0, and in vitro experimental RT-PCR to assess the expression profiles and prognostic significance of TEAD family in OSC. Results: According to the bioinformatics analysis, TEAD family was abnormally expressed in OSC. In terms of prognosis, Kaplan-Meier plotter indicated that OSC patients with high level of TEAD4 showed poor overall survival (OS), progression-free survival (PFS) and post progression survival (PPS). TEAD family also had significantly diagnostic values for OSC patients. Tumor Immune Estimation Resource (TIMER) algorithm indicated that TEAD family was significantly associated with different types of infiltrating immune cells, including B cells, macrophages, dendritic cells, neutrophils, CD8+ T cells and CD4+ T cells. Gene set enrichment analysis of TEAD family-associated coexpression genes was further explored. In in vitro experiments, the RT-PCR results showed the upregulated TEAD2/4 in OSC tissues and cells (A2780 and TOV112D). Moreover, decreased expression of TEAD2 could induce the ferroptosis through increasing the ROS accumulation. Conclusion: Thus, TEAD family correlated with the diagnosis, prognosis and immune infiltration in OSC. These results could provide comprehensive understanding of TEAD family in the diagnosis and prognosis of OSC patients.

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“…TEAD2, like other members of the TEAD family, can bind to YAP (an important member of the evolutionarily conserved Hippo pathway [ 36 ] and activate the expression of anti-apoptosis and proliferation genes. TEAD2 was considered a new tumor prognostic factor [ 37 ]. Tamm et al [ 38 ] revealed that the Yes-YAP-TEAD2 signaling system was downstream of the LIF signaling pathway, which was of great significance to the self-renewal of mouse ESCs.…”

Section: Discussionmentioning

confidence: 99%

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming

Huang

Zhu

Liu

et al. 2021

Stem Cell Rev and Rep

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Background Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs). Many studies have provided a number of alternative combinations to the non-Yamanaka factors. However, it is clear that many additional transcription factors that can generate iPSCs remain to be discovered. Methods The chromatin accessibility and transcriptional level of human embryonic stem cells and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to identify potential reprogramming factors. Selected transcription factors were employed to reprogram urine cells, and the reprogramming efficiency was measured. Urine-derived iPSCs were detected for pluripotency by Immunofluorescence, quantitative polymerase chain reaction, RNA sequencing and teratoma formation test. Finally, we assessed the differentiation potential of the new iPSCs to cardiomyocytes in vitro. Results ATAC-seq and RNA-seq datasets predicted TEAD2, TEAD4 and ZIC3 as potential factors involved in urine cell reprogramming. Transfection of TEAD2, TEAD4 and ZIC3 (in the presence of Yamanaka factors) significantly improved the reprogramming efficiency of urine cells. We confirmed that the newly generated iPSCs possessed pluripotency characteristics similar to normal H1 embryonic stem cells. We also confirmed that the new iPSCs could differentiate to functional cardiomyocytes. Conclusions In conclusion, TEAD2, TEAD4 and ZIC3 can increase the efficiency of reprogramming human urine cells into iPSCs, and provides a new stem cell sources for the clinical application and modeling of cardiovascular disease. Graphical abstract

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TEAD2 as a novel prognostic factor for hepatocellular carcinoma

Cited by 18 publications

References 42 publications

TEADs serve as potential prognostic biomarkers and targets for human gastric cancer

TEADs serve as potential prognostic biomarkers and targets for human gastric cancer

Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming

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