Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice

Sur, Subhayan; Pal, Debolina; Roy, Ranabir Sinha; Barua, Atish; Roy, Anup; Saha, Prosenjit; Panda, Chinmay Kumar

doi:10.1016/j.taap.2016.03.016

Cited by 51 publications

(35 citation statements)

References 42 publications

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“…Tea polyphenols are an important group of natural compounds that have gained popularity as ingredients in dietary supplements and functional foods. Tea polyphenols have also been reported to possess a variety of biological properties that have positive impact on human health [1][2][3], which includes anti-inflammatory, anti-obesity effects and reduced risk of cardiovascular diseases and cancer [4][5][6][7][8]. Green, black and oolong teas are rich sources of polyphenols, the most abundant being catechins and theaflavins.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of eight catechins and four theaflavins in green, black and oolong tea using new HPLC–MS–MS method

Tao

Zhou

Zhao

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of eight catechins and four theaflavins in green, black and oolong tea using new HPLC–MS–MS method

Tao

Zhou

Zhao

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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“…Foods of plant origin are recommended, such as whole grain, vegetable, fruit, and bean, according to the WCRF (, ). Numerous epidemiological studies have shown high dietary intake of fruits and vegetables, containing phytochemicals such as resveratrol, EGCG, carotenoids, antioxidative vitamins, phenolic compounds, organosulfur compounds, flavones, isothiocyanates, indoles, and fibers could reduce cancer risk or prevent multistage carcinogenesis (Bishayee, Politis, & Darvesh, ; Chinni, Li, Upadhyay, Koppolu, & Sarkar, ; Georgia & Catherine, ; Gupta et al., ; Iriti & Varoni, ; Kang, Tsai, & Lee, ; Karen‐Ng et al., ; Stagos et al., ; Sur et al., ). However, there has been no report up to now on the cancer prevention effects of applying multiple food components which are derived from elite crop varieties containing high ACEs.…”

Section: Discussionmentioning

confidence: 99%

“…Each sample was amplified in triplicate. Relative gene expression data were analyzed using the 2 −ΔΔCT method (Sur et al., ).…”

Section: Methodsmentioning

confidence: 99%

Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats

Zheng

Liao

et al. 2018

Food Science & Nutrition

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The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and evaluated their cancer preventive effects on N‐nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis. After 20 weeks of dietary intervention, Diet I and Diet II reduced incidence, size, and number of hepatic nodules (p < 0.01) and prevented hepatic tumor formation in NDEA‐induced hepatocarcinogenesis rats. Low‐grade hepatic dysplasia incidence was 20% for Diet II and 40% for Diet I, and apparent hepatocellular carcinomas (HCC) rates were both 0, while 90% HCC in control diet treatment group (p < 0.01). Diet I and Diet II ameliorated abnormal liver function enzymes, reduced serum alpha fetal protein, tumor‐specific growth factor, dickkopf‐related protein 1, tumor necrosis factor‐alpha and interleukin‐6 levels, regulated hepatic phase I and II xenobiotic‐metabolizing enzymes, enhanced antioxidant capacity, suppressed NDEA‐initiated oxidative DNA damage, and induced apoptosis coupled to down‐regulation of proinflammatory, invasion, and angiogenesis markers. Daily intake of combination diet produced from ACEs‐rich elite crop varieties can effectively prevent or delay occurrence and development of NDEA‐induced hepatocarcinogenesis in rats.

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“…EGCG is a predominant ingredient of catechins (Vuong et al 2010). There are broad application prospects for tea with high EGCG content due to its function in human health (Sur et al 2016;Wei et al 2016). However, EGCG can't be artificially synthesized at present, and it can only be extracted from tea.…”

Section: Discussionmentioning

confidence: 99%

A treasure reservoir of genetic resource of tea plant (Camellia sinensis) in Dayao Mountain

Jiang

Zhao

Zeng

et al. 2017

Genet Resour Crop Evol

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Components of 29 wild type tea single plants collected from Dayao Mountain, in Guangxi province, South China, were investigated. They included tea polyphenols, free amino acids, catechin, amino acid and alkaloid monomers etc. Genetic diversity and clustering analyses were conducted based on the main biochemical components. Meanwhile, genetic relationships among 6 wild type tea plants representing 3 tea populations of Daoyao Mountain with 15 tea varieties grown in Yunnan, Guangdong, Hunan, Fujian provinces were analyzed by random amplified polymorphic DNA. The results showed that wild type tea plants from Dayao Mountain were of rich genetic diversity. Furthermore, some tea germplasms with high quality, including high contents of amino acids, high epigallocatechin gallate, and high caffeine have been discovered. These wild type tea germplasms are of high values for further development values due to their geographical uniqueness.

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Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice

Cited by 51 publications

References 42 publications

Simultaneous determination of eight catechins and four theaflavins in green, black and oolong tea using new HPLC–MS–MS method

Simultaneous determination of eight catechins and four theaflavins in green, black and oolong tea using new HPLC–MS–MS method

Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats

A treasure reservoir of genetic resource of tea plant (Camellia sinensis) in Dayao Mountain

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