Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer

Wang, Shitong; Cui, Weicheng; Pan, Dan; Jiang, Min; Chang, Bing; Sang, Li-Xuan

doi:10.3748/wjg.v26.i6.562

Cited by 77 publications

(58 citation statements)

References 272 publications

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“…The strength of the study included the availability of data pertaining to many potential confounding factors in this rich molecular pathological epidemiology [59] , 60 , [61] , 62 dataset, which were adjusted for in the logistic regression model and Cox regression models. In addition to clarifying the relationships between tumour budding and cytotoxic T-cell response, our study represents one of the most extensive validations of the prognostic significance of ITBCC grading of tumour budding, as well as an investigation of the molecular correlates of tumour budding and PDCs.…”

Section: Discussionmentioning

confidence: 99%

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

et al. 2020

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Background Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. Methods Utilising 915 colon and rectal carcinomas in two U.S.-wide prospective cohort studies, and multiplex immunofluorescence combined with machine learning algorithms, we assessed CD3, CD4, CD8, CD45RO (PTPRC), and FOXP3 co-expression patterns in lymphocytes. Tumour budding and PDC at invasive fronts were quantified by digital pathology and image analysis using the International tumour Budding Consensus Conference criteria. Using covariate data of 4,420 incident colorectal cancer cases, inverse probability weighting (IPW) was integrated with multivariable logistic regression analysis that assessed the association of T-cell subset densities with tumour budding and PDC while adjusting for selection bias due to tissue availability and potential confounders, including microsatellite instability status. Findings Tumour budding counts were inversely associated with density of CD3 + CD8 + [lowest vs. highest: multivariable odds ratio (OR), 0.50; 95% confidence interval (CI), 0.35–0.70; P trend < 0.001] and CD3 + CD8 + CD45RO + cells (lowest vs. highest: multivariable OR, 0.44; 95% CI, 0.31–0.63; P trend < 0.001) in tumour epithelial region. Tumour budding levels were associated with higher colorectal cancer-specific mortality (multivariable hazard ratio, 2.13; 95% CI, 1.57–2.89; P trend < 0.001) in Cox regression analysis. There were no significant associations of PDC with T-cell subsets. Interpretation Tumour epithelial naïve and memory cytotoxic T cell densities are inversely associated with tumour budding at invasive fronts, suggesting that cytotoxic anti-tumour immunity suppresses tumour microinvasion.

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Section: Discussionmentioning

confidence: 99%

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

et al. 2020

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“…The major strength of this study was the use of a molecular pathological epidemiology ( 8–10 ) database of colorectal carcinoma patients in 2 US nationwide prospective cohort studies that integrate clinicopathological and molecular features, long-term survival data, and lifestyle factors, including smoking status and tumor immune profile. The concept of molecular pathological epidemiology has been used widely ( 53–58 ). In particular, examining the interactions between environmental exposures and immune cells in the tumor microenvironment is an important research direction ( 59 ) and may inform strategies to improve clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction

Fujiyoshi

Chen

Haruki

et al. 2020

JNCI Cancer Spectrum

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Background Smoking has been associated with worse colorectal cancer patient survival and may potentially suppress the immune response in tumor microenvironment. We hypothesized that the prognostic association of smoking behavior at colorectal cancer diagnosis might differ by lymphocytic reaction patterns in cancer tissue. Methods Using 1,474 colon and rectal cancer cases within two large prospective cohort studies (Nurses’ Health Study and Health Professionals Follow-up Study), we characterized four patterns of histopathologic lymphocytic reaction, including tumor-infiltrating lymphocytes (TIL), intratumoral periglandular reaction, peritumoral lymphocytic reaction, and Crohn’s-like lymphoid reaction. Using covariate data of 4,420 incident colorectal cancer cases in total, inverse probability weighted multivariable Cox proportional hazards regression model was conducted to adjust for selection bias due to tissue availability and potential confounders, including tumor differentiation, disease stage, microsatellite instability status, CpG island methylator phenotype, long interspersed nucleotide element-1 methylation, and KRAS, BRAF, and PIK3CA mutations. Results The prognostic association of smoking status at diagnosis differed by TIL status. Compared with never smokers, the multivariable-adjusted colorectal cancer-specific mortality hazard ratio for current smokers was 1.50 [95% confidence interval (CI), 1.10-2.06] in tumors with negative/low TIL, and 0.43 (95% CI, 0.16-1.12) in tumors with intermediate/high TIL (two-sided Pinteraction = .009). No statistically significant interactions were observed in the other patterns of lymphocytic reaction. Conclusions : The association of smoking status at diagnosis with colorectal cancer mortality may be stronger for carcinomas with negative/low TIL, suggesting a potential interplay of smoking and lymphocytic reaction in colorectal cancer microenvironment.

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“…The debate continues even today, focusing on the aging process, with a new hypothesis formulated in 2018, "A Free Radical Theory of Frailty", according to which oxidative damage is not entirely related to chronological age, but rather to the health status of the elderly 3 . Antioxidants, as preventive factors against age-related diseases, are confirmed today in many studies [4][5][6][7] . Simultaneously with the growing scientific interest in antioxidants, we are witnessing a demographic challenge for the XXI st century -extending live expectancy and corresponding growth of diseases associated with aging.…”

Section: Introductionmentioning

confidence: 88%

"Polymerase chain reaction-based subtype diversity of Blastocystis species isolates obtained from hospitalized patients with blastocystosis"

TSANOVA-SAVOVA¹,

SAVOVA²,

RIBAROVA³

2020

Arch Balk Med Union

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La densité antioxydante des aliments végétaux typiques dans l'alimentation bulgare et le vieillissement en bonne santé Introduction. La théorie des radicaux libres (Denham Harman, 1950) lance une recherche des antioxydants comme facteurs préventifs contre les maladies dégénératives liées au processus de vieillissement. L'importance des antioxydants dans l'alimentation pour fortifier la défense antioxydante est confirmée dans de nombreuses études, d'où la nécessité de présenter leur contenu dans différents aliments. L'objectif de l'étude est de présenter des données sur la composition des micronutriments antioxydants et des composés biologiquement actifs dans les aliments, typiques du régime bulgare, en raison de leur rôle actif dans la prévention des maladies liées à l'âge, offrant ainsi des choix alimentaires sains et disponibles aux personnes âgées pour un régime de densité des antioxydants. Matériaux et méthodes. Les vitamines E, C et les bioactifs -carotène et flavonoïdes-quercétine, les catéchines et les flavones dans 13 fruits et 13 légumes sont étudiées. Les composés sont analysés par les méthodes HPLC.

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Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer

Cited by 77 publications

References 272 publications

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction

"Polymerase chain reaction-based subtype diversity of Blastocystis species isolates obtained from hospitalized patients with blastocystosis"

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