Tea and Tea Polyphenols in Cancer Prevention

Yang, Chung S.; Yang, Guang; Chung, Jee Young; Lee, M J; Li, C

doi:10.1007/978-1-4615-1283-7_5

Cited by 90 publications

(109 citation statements)

References 34 publications

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“…Further, high doses of fluoride have also been linked to cancer (Marshall 1990). Other experiments carried out in Japan (Tohyama 1996), USA (Takahashi et al 2001) and Taiwan (Yang et al 2000) proved that various types of cancers are associated with fluoride. Further, studies also show that in animals, kidney damage occurs even at lower levels of fluoride exposure over a long time (Manocha et al 1975).…”

Section: Medical Perspectivementioning

confidence: 98%

Worldwide contamination of water by fluoride

et al. 2016

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Fluoride contamination in water is a major problem across the globe, with health hazards such as dental and skeletal fluorosis. Most earlier studies are confined to local or regional scales. As the problem has serious socioeconomic implications, there is a need for a global perspective. Thus, here we review worldwide research for nearly a century on fluoride contamination in water. We investigated the distribution of fluoride contamination in water, its sources, mobilization and association. The major findings are: (1) Anomalous fluoride concentration in groundwater is mainly confined to arid and semiarid regions of Asia and North Africa. (2) The geogenic sources of fluoride in water are mainly fluorine-bearing minerals in rocks and sediments, whereas anthropogenic sources of fluoride in water are mainly pesticides and industrial waste.(3) Fluoride mobilization from geogenic sources is mainly controlled by alkalinity and temperature. (4) Fluoride occurrence in water is associated with ions such as sodium, arsenic chloride and bicarbonate. There are few associations of fluoride in water with calcium and magnesium.

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Section: Medical Perspectivementioning

confidence: 98%

Worldwide contamination of water by fluoride

et al. 2016

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“…This beneficial effect has been attributed to the bioactive compounds of these natural products and first of all to phenolic compounds, due to their ability to act as efficient free radical scavengers. Many plants possess antioxidant activities and their consumption was recommended [4,5]. Therefore, the phytochemicals present in herbal products, marketed as dietary supplements, may act as preventative or therapeutic agents similar to over-the counter (OTC) and prescription drugs.…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line

Encalada

Hoyos

Rehecho

et al. 2011

Plant Foods Hum Nutr

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Melissa officinalis L. (Lamiaceae) is consumed as a traditional herbal tea in the Mediterranean region. The cytotoxic effect of the 50% ethanolic and aqueous extract, determined by the MTT and NR assays, was evaluated in vitro on Human Colon Cancer Cell Line (HCT-116), using Triton 10% as positive control. The 50% ethanolic extract showed significant differences after 72 h of treatment, reducing cell proliferation to values close to 40%, even the lowest dose tested (5 μg/ml). In the MTT assay, the same extract caused the lowest cell viability with 13% at a concentration of 1,000 μg/ml after 72 h of treatment, being a value lower than Triton 10%. The antioxidant activity was also confirmed evaluating the capacity of the extracts to scavenge ABTS and DPPH radicals, and IC(50) values were highly correlated with the total phenolic and flavonoid content. Bioassay guided fractionation led to the isolation of an anti-proliferative compound, rosmarinic acid. Its structural elucidation was performed by HPLC/DAD/ESI/MS analysis. High dose of rosmarinic acid (1,000 μg/ml) was clearly cytotoxic against HCT-116 cells, with a significant decrease in cell number since the earliest time point (24 h).

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“…The methods of preparation differ slightly in China, where it is pan-roasted after harvesting, while in Japan it is steamed and dried naturally. Both methods prevent oxidation of the naturally occurring flavonoid contents [5]. Green tea is rich in polyphenols, including catechins and gallocatechins, which may prevent various human diseases.…”

Section: Introductionmentioning

confidence: 99%

Green tea consumption and breast cancer risk or recurrence: a meta-analysis

Ogunleye

Xue

Michels

2009

Breast Cancer Res Treat

133

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Green tea is a commonly consumed beverage in Asia and has been suggested to have anti-inflammatory and possible anti-carcinogenic properties in laboratory studies. We sought to examine the association between green tea consumption and risk of breast cancer incidence or recurrence, using all available epidemiologic evidence to date. We conducted a systematic search of five databases and performed a meta-analysis of studies of breast cancer risk and recurrence published between 1998 and 2009, encompassing 5,617 cases of breast cancer. Summary relative risks (RR) were calculated using a fixed effects model, and tests of heterogeneity across combined studies were conducted. We identified two studies of breast cancer recurrence and seven studies of breast cancer incidence. Increased green tea consumption (more than three cups a day) was inversely associated with breast cancer recurrence (Pooled RR = 0.73, 95% CI: 0.56-0.96). An analysis of case-control studies of breast cancer incidence suggested an inverse association with a pooled RR of 0.81 (95% CI: 0.75, 0.88) while no association was found among cohort studies of breast cancer incidence. Combining all studies of breast cancer incidence resulted in significant heterogeneity. Available epidemiologic evidence supports the hypothesis that increased green tea consumption may be inversely associated with risk of breast cancer recurrence. The association between green tea consumption and breast cancer incidence remains unclear based on the current evidence.

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Tea and Tea Polyphenols in Cancer Prevention

Cited by 90 publications

References 34 publications

Worldwide contamination of water by fluoride

Worldwide contamination of water by fluoride

Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line

Green tea consumption and breast cancer risk or recurrence: a meta-analysis

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