Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line

Encalada, Manuel Alejandro; Hoyos, Kelly Melissa; Rehecho, Sheyla; Berasategi, Izaskun; Ciriano, Mikel García-Íñiguez de; Ansorena, Diana; Astiasarán, Icíar; Navarro-Blasco, Í.; Cavero, Rita Yolanda; Calvo, María Isabel

doi:10.1007/s11130-011-0256-y

Cited by 84 publications

(58 citation statements)

References 26 publications

(29 reference statements)

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“…According to the in-vitro cytotoxicity analysis, using MTT and NR assays, this plant found as very effective against human colon cancer cell line (HCT-116) (Encalada et al, 2011). M. officinalis is a plant, which has shown several types of biological activity.…”

mentioning

confidence: 99%

Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo

Saraydın¹,

Tuncer²,

Tepe³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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mentioning

confidence: 99%

Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo

Saraydın¹,

Tuncer²,

Tepe³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…For example, a recent study by Karthik kumar et al, showed that RA supplementation reduced cell proliferation markers in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis [30] and other studies in the last five years have described cytotoxic and anti-proliferative roles for RA in a number of other cancer cell types [19,[31][32][33]. In this study, initial experiments examined whether treatment with RA at concentrations ranging from 10-80 µg/ml, could reduce HNSCC cell numbers at 24 hrs.…”

Section: Ra Inhibits Hnscc Cell Viabilitymentioning

confidence: 99%

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Tumur¹,

Guerra²,

Yanni³

et al. 2015

J Cancer Sci Ther

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Objective: Active components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. Rosmarinic acid (RA), a phenolic compound in various herbal plants, is well-recognized for its anti-oxidant, anti-inflammatory, anti-proliferative properties in a variety of cell types. In this report, we describe a novel role for RA as an inhibitor of epidermal growth factor (EGF) stimulated signaling in HNSCC and propose a cellular reactive oxygen species (ROS)-mediated mechanism for the observed effects.Methods: Cellular growth, migration and reactive oxygen species (ROS) profiles were examined in RA-treated and untreated HNSCC cell lines (UM-SCC-6 and UM-SCC-10B) using the WST-1 viability assay, established in vitro migration assays, and the CM-H2DCFDA ROS assay, respectively. The influence of RA on EGF-stimulated phosphorylation and its downstream pathways was evaluated using Western-blotting techniques.Results: RA inhibited cell viability, migration and cellular production of ROS in HNSCC cell lines. Furthermore, RA inhibited EGF-induced phosphorylation of the EGFR at tyrosine residues 992 and 845, which led to downregulation of the phosphatidylinositol 3-kinase Akt (PI3K/Akt) and mitogen-activated protein kinase ERK (MAPK/ ERK) pathways.Conclusions: This is the first report describing both growth-and motility-inhibitory roles for RA in HNSCC cells. Additionally, our study is the first to demonstrate that treatment with RA can reduce EGF-induced activation of PI3K/ Akt in tumor cells. The present data suggests that RA holds promise as a chemotherapeutic agent against HNSCC. a novel strategy to down-regulate EGFR signaling using the phenolic compound, rosmarinic acid. RosmarinicActive components of natural foods are increasingly receiving attention for their chemopreventive and chemotherapeutic potential in a wide variety of cancers. One such food component, rosmarinic acid (RA), is a widely distributed phenolic compound in various herbal plants such as rosemary, sweet basil, sage, mint, and perilla (Figure 1) [10,11]. RA is regarded as a daily-consumed safe ingredient, due to its extensive use in the food industry for flavoring, but studies have also elucidated a medicinal role for RA, especially in regard to its anti-oxidant, and anti-inflammatory activities [12,13]. Furthermore, an emerging body of literature has also described the growth inhibitory and anti-invasion properties of RA in colon, skin, breast and ovarian cancers in vitro and/or in vivo [14][15][16][17][18][19], but the mechanisms underlying these effects are poorly understood. A chemopreventive role for RA in HNSCC has been described in 7,12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis [20], but a chemotherapeutic role for RA in the treatment of HNSCC has not yet been reported.Given the anti-oxidant properties attributed to RA, it is possible that RA's anti-tumor effects stem from its ability to combat oxidative stress in HNSCC. Oxidative ...

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“…According to Bauman,8 in fruits, there are important nutrient besides other vitamins, minerals, flavonoids and phytochemicals, which have been reported as a good contributing factor to the health.In addition, epidemiological studies, including experiments performed on animal models and investigations on humans have proven that consumption of a diet rich in vegetables and fruits is associated with a low risk of contracting some diseases, including cardiovascular diseases and cancers. 9 The genus, L. domesticum corr. belongs to the family Meliaceae, and known locally as duku.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Effect and Morphological Study of Different Duku(Lansium domesticum corr.) Extract towards Human Colorectal Adenocarcinoma Cells Line (HT-29)

Rohin¹,

Noratiqah²,

Ridzwan³

et al. 2017

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Context:Lansium domesticum corr. is a member of the family Meliaceae, and known locally as duku and has been used traditionally in the prevention and treatment of various illness. Aim: To study the cytotoxic effect and morphological changes of human colorectal adenocarcinoma cells (HT-29) treated with different duku (Lansium domesticum corr.) extracts. Methods: The L.domesticum corr. fruit extracts were processed involving three different solvents; methanol, ethanol and ethyl acetate. HT-29 cell lines were treated with different concentrations of L. domesticum corr. (0-100 µg/ml) extracts for a total of 24, 48 and 72 hours. Cytotoxicity of cells line was determined by using MTT assay as per IC 50 values. Results: Methanol extract of L. domesticum corr. showed IC 50 value at 6.79 ± 0.00 µg/ml and 50.0 ± 0.00 µg/ml respective, while ethyl acetate extract of L. domesticum corr. reached IC 50 value at 86.00 ± 0.08 µg/ml, and 96.0 ± 0.12 µg/ml. There was no IC 50 value of ethanol extract from L.domesticum corr. Only methanol extract showed toxicity towards HT-29 cells line. Conclusion: To the best of our knowledge, this is the first repeat the exploring the effect of duku (L. domesticum corr.) extract on HT-29 cells line.

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Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line

Cited by 84 publications

References 26 publications

Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo

Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

Cytotoxicity Effect and Morphological Study of Different Duku(Lansium domesticum corr.) Extract towards Human Colorectal Adenocarcinoma Cells Line (HT-29)

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