Tea and coffee consumption in relation to DNA methylation in four European cohorts

Ek, Weronica E.; Tobi, Elmar W.; Ahsan, Muhammad; Lampa, Erik; Ponzi, Erica; Kyrtopoulos, Soterios A.; Georgiadis, Panagiotis; Lumey, L. H.; Heijmans, Bastiaan T.; Botsivali, Maria; Bergdahl, Ingvar A.; Karlsson, Torgny; Rask‐Andersen, Mathias; Palli, Domenico; Ingelsson, Erik; Hedman, Åsa K.; Nilsson, Lena; Víneis, Paolo; Lind, Lars; Flanagan, James M.; Johansson, Åsa

doi:10.1093/hmg/ddx194

Cited by 29 publications

(23 citation statements)

References 74 publications

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“…In our study, EWAS meta-analysis of tea consumption showed only two suggestive associations, despite having the advantage of much larger sample size and good statistical power compared to the previously published EWA study 20 . In the earlier study, Ek et al reported two CpGs associated with tea consumption in women, nevertheless, those CpGs were not replicated in our study.…”

Section: Discussioncontrasting

confidence: 75%

“…Here, we postulate that alteration of DNA methylation via coffee or tea consumptions is an underlying mechanism linking the intake of these beverages to health outcomes. Previous epigenome-wide association studies (EWAS) have reported suggestive association of a few CpGs with tea or coffee consumptions 20,21 ; however, these studies were limited by modest sample sizes. In the present study, we conducted large-scale EWAS meta-analyses on coffee and tea consumptions in 15,789 participants of European and African-American ancestries from 15 cohort studies.…”

Section: Introductionmentioning

confidence: 99%

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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Karabegović

Portilla‐Fernandez

et al. 2020

Preprint

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Coffee and tea are extensively consumed beverages worldwide. Observational studies have shown contradictory findings for the association between consumption of these beverages and different health outcomes. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. We conducted epigenome-wide association studies (EWAS) on coffee and tea consumptions in 15,789 participants of European and African-American ancestries from 15 cohorts.EWAS meta-analysis revealed 11 CpG sites significantly associated with coffee consumption (P-value <1.1×10 -7 ), nine of them annotated to the genes AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH, and two CpGs suggestively associated with tea consumption (P-value<5.0×10 -6 ). Among these, cg14476101 was significantly associated with expression of its annotated gene PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells showed a correlation with expression levels of lipid-associated genes, suggesting a role of PHGDH in hepatic-lipid metabolism.Collectively, this study indicates that coffee consumption is associated with differential DNA methylation levels at multiple CpGs, and that coffee-associated epigenetic variations may explain the mechanism of action of coffee consumption in conferring disease risk.

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Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Karabegović

Portilla‐Fernandez

et al. 2020

Preprint

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“…it mainly by the death of dopamine-producing neurons in our brain [86][87][88][89][90][91] Coffee consumption protects against 65 or more aged people from Alzheimer's disease and dementia. It lower 65% risk of Alzheimer's disease…”

Section: Health Benefit Of Coffee Consumption Description Of Action Smentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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Coffee is the world's beloved drink that is the most regularly consumed caffeine-containing beverage next to water and tea. It contains a multipart combination of chemicals constituents, which associated with health benefits, most consumers, begin their day with a minimum a cup of coffee after eating food, and end their workday with coffee. It is considered as a significant part of modern daily life because it has an alerting outcome on the human brain. Opposing this, various groups report experiencing uneven health risks thus hesitant to drink coffee, this suggests individual disparity to coffee intolerance. The aim of this review was to in brief summarize health benefits and risks coffee consumption. Most of the informative reports suggested that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among these it is used to boosts our physical performance, burn fat, reduces risk of stroke, liver, prostate and colorectal cancer by 20%, risk of Parkinson's disease by 25%, lower risk of Type II diabetes, reduces risk of dementia and protects our mind, brightens our mood, helps us to fight depression and minimize risk of suicide by 50%. In addition, coffee consumers have less risk of heart disease, with strongly integrated DNA. Also reports that coffee drinking has also naturally extended sleep latency, minimizes total sleep time and its effectiveness, and worsened supposed sleep feature.However, from positive health prospect of coffee consumption, a recent study finds coffee consumption does not always provide protective benefits because overdrinking is associated with negative impact or risk on our health. Some negative impact of coffee consumption on our health; it reduces appetite levels for food, impact on pregnant women, on people with cholesterol, cause insomnia and restlessness, breast tissue cysts in women, incontinence digestive disorders, and risk of headaches. In addition, decrease fertility probability in female and male, cause allergies and miscarriage, forceful heart contractions, anxiety, depression and the need for anxiety medication, inhibits collagen production in the skin of human being, less hearing loss improvement, does not help with extended sleep deprivation interferes with ossification and could also lead to greater risk of bone fracture. Finally, the most recent studies reported that coffee consumption is beneficial for our health when it is optimum range approximately four cups on average. The supplementary research will be crucial to make clear that both the health benefits and risk of coffee consumption.

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“…A recent epidemiological study was conducted to evaluate the in vivo effects of green tea consumption on human DNA. The analysis revealed that 28 regions were differentially methylated in relation to green tea consumption, but only in women [21]. This indicates that some genomic regions are relatively more sensitive to DNA demethylating compounds, which are known to act through several mechanisms.…”

Section: Discussionmentioning

confidence: 95%

New Insights into the Epigenetic Activities of Natural Compounds

Vidaković¹,

Marinello²,

Lahtela‐Kakkonen³

et al. 2018

obm genet

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Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic activities. In this study, we screened a small natural compound library for epigenetic activities. Methods: Seventy-one different natural products plus 17 controls collected from all collaborating laboratories were screened. Localized DNA methylation (DNAm) was studied on a stretch of the retinoic acid receptor gene RAR. All genomic 5-methylated cytosine (5mC) bases were then detected by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). DNA methyl transferase 1 (DNMT1) enzymatic activity was measured for selected compounds. Level of histone H3 trimethylation at lysine 9 and 27 (me3H3K9 and me3H3K27) was measured by Western blot analysis. Global histone deacetylase inhibition (HDAC) was assayed first using a bioluminescent resonance energy transfer-based (BRET) assay and then with enzymatic fluorescence based-assays for most HDAC class 1. HDAC6 inhibition was measured by Western blot analysis. Sirtuin (Sirt2) inhibition was assessed first with a thermal shift assay and then using the enzymatic SIRTainty™ Class III HDAC assay for Sirt1 and Sirt2. Results: Diosmetin, (S)-equol, umbelliferone, papaverin and L-carnitine were identified as novel DNA demethylating agents. Emodin, rhein, aloin and D-glucuronic acid were identified as novel histone H3 demethylating compounds. Previously undescribed Sirt activation by apigenin, biochanin B, robinin, pinocembrin, aureusidine, brucine and boldine was also detected. Conclusions: High-throughput alpha screens are used for initial studies of diverse compound libraries; however, this approach has significant disadvantages for the study of DNAm. Indeed, finding unmethylated RARalleles in one cell line does not indicate the activity of the compound at the level of the entire genome over a given time-frame and a given dose. Measurement of DNMT1 activity is not useful since most natural compounds are not direct enzymatic inhibitors. When studying histone methylation, Western blot analysis is laborious

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Tea and coffee consumption in relation to DNA methylation in four European cohorts

Cited by 29 publications

References 74 publications

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Review on Health Benefit and Risk of Coffee Consumption

New Insights into the Epigenetic Activities of Natural Compounds

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