TD-09 IL-34 promotes macrophage-mediated lupus nephritis in MRL-Fas^lpr mice

Abstract

class III/IV LN. Using RNA-in-situ hybridization methods, we document infiltration of class III/IV nephrtis biopsy tissue with PDCs with IFN-signature positive cells surrounding them, supporting local production of type I IFNs. Conclusions Our data support an association between type I IFN and class III/IV nephritis that is independent of overall SLEDAI and anti-dsDNA antibodies, suggesting that IFN is involved in renal pathogenesis. These data also suggest that IFN could predict renal disease activity or the future risk of developing LN, especially class III/IV LN in EA SLE patients.

Interleukin-34 as a marker for subclinical proliferative lupus nephritis

“…One experimental study, done on intra-renal IL-34, proved that IL-34 was up-regulated in renal tubular epithelial cells and had a role in macrophage recruitment in comparison to healthy controls where the level of intra-renal IL-34 was low. 42 Many cytokines are involved and contribute to both the onset and progression of renal pathology such as IL-17, 43 IL-18, 44 IL-22, 45 IL-23 46 and IFN-γ. 47 However, too many contradictions are found in the precise role of these cytokines, and it is hard to state which one could be the predictive marker for any pathology by itself.…”