TCR gamma delta Cells: A Specialized T Cell Subset in the Immune System

Bluestone, J. A.

doi:10.1146/annurev.cellbio.11.1.307

Cited by 25 publications

(34 citation statements)

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“…of enrichment for specific TCR V␥V␦-paired T cell subsets within RCC tissues is not entirely unexpected since it is well established that ␥␦ T cells (bearing paired V␥V␦ TCR and exhibiting limited VDJ diversity) distribute themselves throughout the host in an organ-specific fashion following thymic emigration, presumably to provide a first line of immunologic defense against pathogenic insults specific to each organ type or to down-regulate organ-specific TCR ␣␤ T cell-mediated autoimmunity (22,23). With regard to lysis of RCC tumor cells by ␥␦ T cells, the published literature simply fails to support specific lysis of RCC tumors by Phosphostim-expanded (Innate Pharma) TCR V␥9V␦2 T cells.…”

Section: Discussionmentioning

confidence: 99%

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Inman¹,

Frigola²,

Harris³

et al. 2008

The Journal of Immunology

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Adoptive γδ T cell immunotherapy has moved briskly into clinical trials prompted by several small studies suggesting abundant accumulation of γδ T cells within renal cell carcinoma (RCC). In this study, we re-examined levels of γδ T cells within RCC tumors and correlated levels of these cells with pathologic features and outcome associated with this form of cancer. Tissues from 248 consecutive clear cell RCC tumors obtained from 2000 to 2003 were stained and quantified for total CD3+ and γδ T cells per mm2. Wilcoxon rank sum and Kruskal-Wallis tests were used to evaluate associations between T cell amounts and prognostic factors (age, gender, tumor size, stage, grade, tumor necrosis). Cox models were used to assess associations with RCC-specific death. Median numbers of total CD3+ and γδ T cells were 281/mm2 (interquartile range (IQR): 149–536) and 2.6/mm2 (IQR: 1.3–4.6), respectively. The median percentage of CD3+ T cells that were γδ T cells was 1.0% (IQR: 0.4–1.9). This low percentage of intratumoral γδ T cells was diluted even further with rising CD3+ T cell infiltration. Percentages of γδ T cells were not associated with even one single clinicopathologic feature examined. Median follow-up for this study was 3.1 years (48 patients died of RCC) and Cox analysis failed to demonstrate that γδ T cells (hazard ratio = 1.02, p = 0.25) were predictive of RCC-specific death. γδ T cells are rare and not recruited nor expanded within RCC tumors. Percentages of γδ T cells fail to correlate with any prognostic features of RCC nor specific death. As such, the role of γδ T cells in RCC immunobiology remains questionable.

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Section: Discussionmentioning

confidence: 99%

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Inman¹,

Frigola²,

Harris³

et al. 2008

The Journal of Immunology

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“…6,14 This distribution of disease reflects the localization of normal ␥␦ T cells, which are believed to play a role in host mucosal and epithelial immune responses. 8,19 Mucosal and cutaneous ␥␦ T-cell lymphomas differ from hepatosplenic ␥␦ T-cell lymphomas, which are derived from functionally immature ␥␦ T cells, positive for TIA-1, but negative for granzyme B and perforin. 12,18,39 It is possible that the activated cytotoxic phenotype contributes to the aggressive clinical behavior, as suggested in prior studies.…”

Section: Discussionmentioning

confidence: 99%

“…7 The T-cell receptor consists of either a gamma-delta (␥␦) or an alpha-beta (␣␤) heterodimer expressed in association with the CD3 complex of proteins on the cell surface. 8 The majority of mature T cells express the ␣␤ T-cell receptor. However, 5% of normal T cells express the ␥␦ T-cell receptor.…”

Section: Introductionmentioning

confidence: 99%

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Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma

Toro

Liewehr

Pabby

et al. 2003

Blood

276

256

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The importance of ␣␤ versus ␥␦ T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor-␦1 (TCR␦1) expression in primary cutaneous T-cell lymphomas. TCR␦1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. Univariate analysis indicated that there was a statistically significant difference in survival between the patients with ␣␤ cutaneous T-cell lymphoma and patients with ␥␦ cutaneous T-cell lymphoma (P < .0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and/or dermal involvement (P < .0001). Cox model analysis indicated that TCR␦1 expression was the factor that was most closely associated with decreased survival (P < .0001). Among those patients with cutaneous ␥␦ T-cell lymphoma (n ‫؍‬ 33), there was a trend for decreased survival for patients who had histologic evidence of subcutaneous fat involvement in comparison with patients who had epidermotropic or dermal patterns of infiltration (P ‫؍‬ .067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR␦1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival. (Blood.

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“…By contrast, the second subset of V␦1 T cells is resident mainly in the oral and intestinal epithelia, where these cells might provide a first line of defense against viral infections or malignancies (16). ␥␦ T cells have been implicated in antiviral immune responses on the basis of their selective expansion in the peripheral blood of patients infected with HIV, CMV, EBV, and HSV (17)(18)(19)(20)(21).…”

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confidence: 99%

γδ+ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection

Barcy¹,

Rosa²,

Vieira³

et al. 2008

The Journal of Immunology

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Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV−HHV-8+ and HIV−HHV-8− infected human individuals. αβ+ T cells from HHV-8-infected individuals displayed a significantly higher percentage of differentiated effector cells among both CD4+ and CD8+ T cell subsets. HHV-8 infection was associated with significant expansion of γδ+ Vδ1 T cells expressing a differentiated effector cell phenotype in peripheral blood. In vitro stimulation of PBMC from HHV-8-infected individuals with either infectious viral particles or different HHV-8 viral proteins resulted in γδ Vδ1 T cell activation. In addition, γδ Vδ1 T cells displayed a strong reactivity against HHV-8-infected cell lines and prevented the release of infectious viral particles following the induction of lyric replication. These data indicate that γδ T cells play a role in both innate and adaptive T cell responses against HHV-8 in immunocompetent individuals.

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TCR gamma delta Cells: A Specialized T Cell Subset in the Immune System

Cited by 25 publications

References 0 publications

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma

γδ+ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection

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