TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression

Sun, Shangfeng; Yang, Xiuxiu; Qin, Xingping; Yan-hua, Zhao

doi:10.1007/s00709-020-01480-6

Cited by 20 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, CHAF1A was demonstrated to interact with TCF4, which promotes gastric carcinogenesis (Zheng et al, 2018), while β-catenin/ TCF4 complex can induce the EMT-activator ZEB1 to regulate tumor invasion (Sánchez-Tilló et al, 2011). Moreover, TCF4 can regulate ZEB1/ZEB2 expression in drug resistance and stemness of colorectal cancer (Sun et al, 2020). These studies indicated that a regulatory mechanism might exist for CHAF1A and ZEB1.…”

Section: Introductionmentioning

confidence: 86%

MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

Zhong

Sang

et al. 2021

Acta Biochim Pol

View full text Add to dashboard Cite

The anticancer effect of miR-1179 has been extensively studied in many tumors. The mechanism of miR-1179 action in cervical cancer, however, remains largely unknown. In the present study, miR-1179 was downregulated in both cervical cancer cell lines and cancer tissues. In addition, miR-1179 mimic suppressed cancer cells invasion and epithelial-mesenchymal transition (EMT) in cervical cancer SiHa and Caski cells. We found that chromatin assembly factor 1 subunit A (CHAF1A) might be a direct target of miR-1179 and could be regulated by miR-1179. Furthermore, CHAF1A shRNA suppressed the cervical cancer cells invasion and the expression of EMT-promoted proteins. Reversely, CHAF1A overexpression not only promoted cervical cancer cells invasion but also upregulated the level of Zinc finger E‐box binding protein 1 (ZEB1), an EMT-related protein. The induction of ZEB1 could be counteracted by miR-1179 overexpression. It was observed that in cervical cancer patients’ tissues, miR-1179 was downregulated while the pathway of CHAF1A/ZEB1 was upregulated. In summary, our research indicated that the miR-1179 might regulate CHAF1A/ZEB1 axis and inhibit the invasion of cervical cancer cells.

show abstract

Section: Introductionmentioning

confidence: 86%

MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

Zhong

Sang

et al. 2021

Acta Biochim Pol

View full text Add to dashboard Cite

show abstract

“…As the p‐type silicon has achieved market‐oriented production, its preparation process and properties would be no longer discussed here. In recent years, ZnO has attracted great attention due to its low cost, facile preparation technique, and eco‐friendly properties . This section focuses on the doped p‐type ZnO nanomaterials and introduces other doped p‐type semiconductors briefly.…”

Section: Common P‐type Semiconductor Materialsmentioning

confidence: 99%

Photoelectric Detectors Based on Inorganic p‐Type Semiconductor Materials

et al. 2018

View full text Add to dashboard Cite

Photoelectric detectors are the central part of modern photodetection systems with numerous commercial and scientific applications. p-Type semiconductor materials play important roles in optoelectronic devices. Photodetectors based on p-type semiconductor materials have attracted a great deal of attention in recent years because of their unique properties. Here, a comprehensive summary of the recent progress mainly on photodetectors based on inorganic p-type semiconductor materials is presented. Various structures, including photoconductors, phototransistors, homojunctions, heterojunctions, p-i-n junctions, and metal-semiconductor junctions of photodetectors based on inorganic p-type semiconductor materials, are discussed and summarized. Perspectives and an outlook, highlighting the promising future directions of this research field, are also given.

show abstract

“…For instance, Zhou et al 14 reported that ZEB1 could recruit DNMT3A and HDAC1 and induce the hypermethylation of the neurogenin 3 (Ngn3) promotor, and thus enhance the cancer stemness in breast cancer cells. Also, Sun et al 15 indicated that ZEB1 is involved in the TCF‐4 induced CSC properties. However, it remains not clear whether miR‐186‐5p and ZEB1 affect the CSC properties in OC.…”

Section: Introductionmentioning

confidence: 99%

Expression of Concern: LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR‐186‐5p/ZEB1 axis

Zhan

Chen

Yao

2020

Cell Biochemistry & Function

View full text Add to dashboard Cite

LncRNA TUG1 has been rarely studied in ovarian cancer (OC), our objective was to explore the role of TUG1 in the regulation of malignant phenotypes of OC. Vectors of sh-TUG1, miR-186-5p and pcDNA-ZEB1 were, respectively, constructed and used to infect OC cells. MTT and transwell assays were applied for representing cell proliferation and invasion, respectively. Sphere formation experiment was used to detect the stemness of OC cells. Western blotting and qRT-PCR were employed for detecting the expression of multiple biomarkers on protein and RNA levels, respectively. The luciferase assay was performed to reveal the interactions between miR-186-5p and TUG1 or ZEB1. The silencing of TUG1 and upregulation of miR-186-5p both suppressed the cell proliferation, invasion and cancer stem cell (CSC) properties. Additionally, luciferase assay verified that miR-186-5p directly binds TUG1 and ZEB1. Moreover, overexpression of ZEB1 rescued the impact on the proliferation, invasion and stemness of TUG1 silencing in OC. TUG1 sponges miR-186-5p to release ZEB1 and promotes the proliferation, invasion and stemness of OC cells, suggesting that TUG1 could be a potential therapeutic target for OC therapy. Significance of the study: LncRNA TUG1 could promote proliferation, invasion and stemness of ovarian cancer cells. Our study first discovered that TUG1 play a tumourigenic role in ovarian cancer by regulating stemness of cancer cells. Mechanism research exhibited the regulation role of TUG1 in ovarian cancer cells was miR-186-5p/ZEB1 axis depended. These results provided a new perspective to understand the pathogenesis and development of ovarian cancer; it will offer new evidence for better diagnosis and treatment therapy of ovarian cancer.

show abstract

TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression

Cited by 20 publications

References 26 publications

MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

Photoelectric Detectors Based on Inorganic p‐Type Semiconductor Materials

Expression of Concern: LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR‐186‐5p/ZEB1 axis

Contact Info

Product

Resources

About