MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

Lv, Fahui; Zhong, Youwen; Sang, Ling; Wu, Xiaoling

doi:10.18388/abp.2020_5499

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…We first identified the circ_0055976/miR‐1179/LDHA axis in HCC cells. Previous findings have identified the antitumor properties of miR‐1179 33,34 . In HCC, miR‐1179 could impair the invasion, proliferation, and migration of HCC cells, which might be related to miR‐1179/NUAK2 axis 35 or circFOXM1/miR‐1179/SPAG5 axis, 36 which was consistent with our findings.…”

Section: Discussionsupporting

confidence: 92%

“…Previous findings have identified the antitumor properties of miR-1179. 33,34 In HCC, miR-1179 could impair the invasion, proliferation, and migration of HCC cells, which might be related to miR-1179/NUAK2 axis 35 or circFOXM1/miR-1179/SPAG5 axis, 36 which was consistent with our findings. Moreover, we also confirmed miR-1179 could suppress anaerobic glycolysis in HCC cells.…”

Section: Discussionsupporting

confidence: 89%

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Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Chang,

Li,

Huang

et al. 2023

Environmental Toxicology

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BackgroundMatrine has been identified to have anticancer activity in hepatocellular carcinoma (HCC). Circ_0055976 was highly expressed in HCC. Here, we investigated the function and relationship of Matrine and circ_0055976 in HCC tumorigenesis.MethodsCell proliferation and invasion were detected using Cell Counting Kit‐8, 5‐Ethynyl‐2′‐deoxyuridine (EdU), colony formation and transwell assays, respectively. Cell aerobic glycolysis was evaluated by detecting glucose consumption, lactate production, and the ratios of ATP/ADP. Levels of genes and proteins were detected by quantitative real‐time polymerase chain reaction and Western blotting. The target relationship between miR‐1179 and circ_0055976 or lactate dehydrogenase A (LDHA) was analyzed by dual‐luciferase reporter assay. The mouse xenograft model was established to conduct the in vivo assay.ResultsMatrine suppressed HCC cell proliferation, invasion and anaerobic glycolysis in vitro. Circ_0055976 was highly expressed in HCC tissues and cells, and was reduced by Matrine treatment. Moreover, overexpression of circ_0055976 reversed the anticancer effects of Matrine in HCC cells. Mechanistically, circ_0055976/miR‐1179/LDHA formed an axis. Circ_0055976 knockdown or miR‐1179 overexpression impaired HCC cell proliferation, invasion, and anaerobic glycolysis, which were reversed by miR‐1179 inhibition or LDHA overexpression. Meanwhile, forced expression of LDHA abolished the regulatory effects of Matrine on HCC cells. In the clinic, Matrine impeded HCC tumor growth in vivo, and this effect was boosted after circ_0055976 silencing.ConclusionMatrine suppressed HCC cell proliferation, invasion, and anaerobic glycolysis via circ_0055976/miR‐1179/LDHA axis, providing a new insight into the clinical application of Matrine in HCC treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Chang,

Li,

Huang

et al. 2023

Environmental Toxicology

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Circ_0000263 facilitates the proliferation and inhibits the apoptosis of cervical cancer depending on the regulation of miR-1179/ABL2 axis

Zhang

Chen

et al. 2022

Reprod. Sci.

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An immune-related microRNA signature prognostic model for pancreatic carcinoma and association with immune microenvironment

Shen

Pan

et al. 2022

Sci Rep

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To establish a prognostic model based on immune-related microRNA (miRNA) for pancreatic carcinoma. Weighted correlation network analysis (WGCNA) was performed using the "WGCNA" package to find the key module genes involved in pancreatic carcinoma. Spearman correlation analysis was conducted to screen immune-related miRNAs. Uni- and multi-variate COX regression analyses were carried out to identify miRNAs prognostic for overall survival (OS) of pancreatic carcinoma, which were then combined to generate a prognostic model. Kaplan–Meier survival analysis, receiver operating characteristic (ROC) analysis, distribution plot of survival status in patients and regression analysis were collectively performed to study the accuracy of the model in prognosis. Target genes of the miRNAs in the model were intersected with the key module genes, and a miRNA–mRNA network was generated and visualized by Cytoscape3.8.0. TIMER analysis was conducted to study the abundance of immune infiltrates in tumor microenvironment of pancreatic carcinoma. Expression levels of immune checkpoint genes in subgroups stratified by the model were compared by Wilcoxon test. Gene Set Enrichment Analysis (GSEA) was performed to analyze the enriched signaling pathways between subgroups. Differential analysis revealed 1826 genes differentially up-regulated in pancreatic carcinoma and 1276 genes differentially down-regulated. A total of 700 immune-related miRNAs were obtained, of which 7 miRNAs were significantly associated with OS of patients and used to establish a prognostic model with accurate predictive performance. There were 99 mRNAs overlapped from the 318 target genes of the 7 miRNAs and the key modules genes analyzed by WGCNA. Patient samples were categorized as high or low risk according to the prognostic model, which were significantly associated with dendritic cell infiltration and expression of immune checkpoint genes (TNFSF9, TNFRSF9, KIR3DL1, HAVCR2, CD276 and CD80). GSEA showed remarkably enriched signaling pathways in the two subgroups. This study identified an immune-related 7-miRNA based prognostic model for pancreatic carcinoma, which could be used as a reliable tool for prognosis.

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MiR-1179 is downregulated in cervical cancer and its overexpression suppresses cancer cells invasion by targeting CHAF1A/ZEB1

Cited by 3 publications

References 27 publications

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Circ_0000263 facilitates the proliferation and inhibits the apoptosis of cervical cancer depending on the regulation of miR-1179/ABL2 axis

An immune-related microRNA signature prognostic model for pancreatic carcinoma and association with immune microenvironment

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