Tc-99m Sestamibi Before and During Treatment in a Patient With Sarcoidosis and Persistent Hyperparathyroidism

Ac, Fröberg; Ww, de Herder; H, Jaap Bonjer; Ep, Krenning; H, Yoe Oei; Dj, Kwekkeboom

doi:10.1097/00003072-200005000-00006

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…13 We report a case of cervical lymph node sarcoidosis misdiagnosed as parathyroid adenoma. Accumulation of MIBI in hilar lymph nodes and in pulmonary interstitial fibrosis in sarcoidosis has been reported previously; [14][15][16] other cases of sarcoidosis have been misinterpreted as primary hyperparathyroidism before the MIBI was introduced into clinical practice. 12,13 A case of active sarcoid mimicking a mediastinal parathyroid adenoma on MIBI scan was previously described by Klieger.…”

Section: Introductionmentioning

confidence: 83%

“…The precise uptake mechanism in sarcoidosis is unknown. 15 Lymph nodes with sarcoid involvement are found in 23% to 37% of patients with sarcoidosis. 13 Accumulation of MIBI in hilar lymph node and in pulmonary interstitial fibrosis in sarcoidosis has been reported previously.…”

Section: Discussionmentioning

confidence: 99%

“…13 Accumulation of MIBI in hilar lymph node and in pulmonary interstitial fibrosis in sarcoidosis has been reported previously. [14][15][16] It is a rare to observe other lymph nodes outside the chest showing increased uptake. 14 Before the introduction of MIBI scanning into clinical practice, cases of sarcoidosis misinterpreted as primary hyperparathyroidism have been described.…”

Section: Discussionmentioning

confidence: 99%

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Cervical Lymph Node Sarcoidosis Mimicking a Parathyroid Adenoma: A Clinical Case

Calò

Pisano

Tatti

et al. 2013

Clin Med Insights Case Rep

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We report a case of cervical lymph node sarcoidosis misdiagnosed as parathyroid adenoma. This is the second case described in the literature in which lymph node sarcoidosis was misdiagnosed as parathyroid adenoma on Tc-99m sestamibi (MIBI) scan, the first case localized in the neck. A 64-year-old woman presented with a hypercalcemia. Neck ultrasonography revealed a paratracheal hypoechoic mass of 15 mm with peripheral vascularization. MIBI scan and SPECT/CT identified a MIBI-positive area corresponding to the nodule detected by ultrasonography suggestive for a lower right parathyroid adenoma. A mass interpreted as the lower parathyroid was excised associated to a total thyroidectomy. Pathologic examination revealed a granulomatous lymph node consistent with active sarcoidosis. Sarcoidosis should be suspected as a cause of unexplained hypercalcemia and the differential diagnosis of hypercalcemia, even in presence of MIBI uptake, must include sarcoidosis localized in an isolated cervical lymph node.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cervical Lymph Node Sarcoidosis Mimicking a Parathyroid Adenoma: A Clinical Case

Calò

Pisano

Tatti

et al. 2013

Clin Med Insights Case Rep

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“…MIBI накапливается и в гиперметаболических узлах ЩЖ, опухолях из окси-фильных клеток, метастазах рака ЩЖ, раке молоч-ной железы, а также в лимфатических узлах при ту-беркулезе и саркоидозе [20][21][22][23][24][25]. Учитывая разное накапение MIBI при саркоидозе до начала и в про-цессе лечения, предлагалось использовать данный метод для оценки эффективности терапии [26].…”

Section: Discussionunclassified

Difficulties of differential diagnostics of primary hyperparathyroidism and sarcoidosis of cervical lymph nodes

Severskaya

Северская²,

Semin

et al. 2015

Probl Endokrinol (Mosk)

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A case of isolated sarcoidosis of cervical lymph nodes is reported that was first erroneously interpreted as parathyroid adenoma. The patient was a 70 year-old woman presenting with hypercalcemia and elevated blood parathormone level. The ultrasound study showed the presence of a tissue mass measuring 1.5 cm in the projection of the inferior right parathyroid gland. The scintigraphic study with 99mTc MIBI demonstrated the accumulation of the radiopharmacological agent in the tissue mass that was identified as an adenoma of the parathyroid gland. The surgical removal of this neoplasm together with the adjacent lymph nodes resulted in the normalization of the blood calcium and parathormone levels. The histological study revealed sarcoidosis of lymph nodes in the absence of lesions in other organs. A literature review of the problem pertaining to hypercalcemia associated with sarcoidosis of cervical lymph nodes is presented with special reference to the difficulties encountered in differential diagnostics of this condition.

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“…Malignant lymphadenopathy has been shown to accumulate 99m Tc‐MIBI in metastatic melanoma and breast, thyroid, or pelvic malignancy. The 99m Tc‐MIBI is also taken up by mediastinal lymph nodes in sarcoidosis 26–30 . Cutaneous KS is often complicated by venous stasis of the extremities, face and genitals.…”

Section: Discussionmentioning

confidence: 99%

^99mTc‐MIBI imaging of cutaneous AIDS‐associated Kaposi's sarcoma

et al. 2007

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Tc-99m Sestamibi Before and During Treatment in a Patient With Sarcoidosis and Persistent Hyperparathyroidism

Cited by 3 publications

References 10 publications

Cervical Lymph Node Sarcoidosis Mimicking a Parathyroid Adenoma: A Clinical Case

Cervical Lymph Node Sarcoidosis Mimicking a Parathyroid Adenoma: A Clinical Case

Difficulties of differential diagnostics of primary hyperparathyroidism and sarcoidosis of cervical lymph nodes

^99mTc‐MIBI imaging of cutaneous AIDS‐associated Kaposi's sarcoma

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