Tc-99m HMPAO Leukocyte and Tc-99m Nanocolloid Scintigraphy in Posttraumatic Bone Infection

Papós, Miklós; Barát, Ferenc; Nárai, G; Dillmann, József; J, Láng; Csernay, L.

doi:10.1097/00003072-199807000-00005

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…When patients with slightly increased activity were regarded as being negative, the specificity increased to nearly 100%. 54 This is in agreement with a study by Papos et al, 55 which suggests both 99m Tc-NC and 99m…”

Section: Nuclear Medicine Techniques For Diagnosis Of Osteomyelitissupporting

confidence: 90%

Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Blazeski¹,

Kozloff

Scott³

2010

RMI

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Section: Nuclear Medicine Techniques For Diagnosis Of Osteomyelitissupporting

confidence: 90%

Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Blazeski¹,

Kozloff

Scott³

2010

RMI

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“…Other studies have applied a similar semiquantitative method, not only for prosthesis infection but also for soft tissue infection [ 161 ], post-traumatic osteomyelitis [ 176 ], and diabetic foot infection [ 35 ], or even with other radiopharmaceuticals such as FDG [ 34 , 35 , 177 ]. All studies were in agreement on the usefulness of semiquantitative evaluation of WBC accumulation in infected lesions over time.…”

Section: Consensus Statementsmentioning

confidence: 99%

Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement)

Signore

Sconfienza

Borens

et al. 2019

Eur J Nucl Med Mol Imaging

141

108

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Background For the diagnosis of prosthetic joint infection, real evidence-based guidelines to aid clinicians in choosing the most accurate diagnostic strategy are lacking. Aim and Methods To address this need, we performed a multidisciplinary systematic review of relevant nuclear medicine, radiological, orthopaedic, infectious, and microbiological literature to define the diagnostic accuracy of each diagnostic technique and to address and provide evidence-based answers on uniform statements for each topic that was found to be important to develop a commonly agreed upon diagnostic flowchart. Results and Conclusion The approach used to prepare this set of multidisciplinary guidelines was to define statements of interest and follow the procedure indicated by the Oxford Centre for Evidence-based Medicine (OCEBM). Electronic supplementary material The online version of this article (10.1007/s00259-019-4263-9) contains supplementary material, which is available to authorized users.

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“…The sensitivity of 3-phase bone imaging has been reported to be between 70% and 100%, with an average of 92%, whereas the average specificity might be as low as 32% (8). Because labeled leukocytes do not accumulate at the site of increased bone turnover, the addition of 99m Tc-hexamethylpropyleneamine oxime (HMPAO) white blood cell (WBC) imaging has been helpful in diagnosing bone infection in violated bones, such as after trauma, after surgery, and from diabetic foot infection (9)(10)(11). The overall 99m Tc-HMPAO WBC sensitivity and specificity are 88% and 91%, respectively, in osteomyelitis of previously violated bones (9,(12)(13)(14).…”

mentioning

confidence: 99%

The Value of Quantitative Uptake of 99mTc-MDP and 99mTc-HMPAO White Blood Cells in Detecting Osteomyelitis in Violated Peripheral Bones

Ballani

Al-Huda²,

Khan³

et al. 2007

Journal of Nuclear Medicine Technology

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Our objective in this study was to evaluate whether measurement of quantitative uptake of 99m Tc-methylene diphosphate (MDP) and 99m Tc-hexamethylpropyleneamine oxime (HMPAO) white blood cells (WBCs) is useful in detecting osteomyelitis in peripheral bony lesions. Methods: Twenty-four patients (12 men and 12 women; age range, 25-72 y) were referred for imaging because of clinically suspected osteomyelitis. They had a traumatic fracture (n 5 10), knee prosthesis (n 5 5), hip prosthesis (n 5 2), diabetic foot (n 5 4), or chronic osteomyelitis (n 5 3). Threephase bone scanning and 99m Tc-HMPAO WBC studies were performed on all patients within the same week. Regions of interest were drawn over the abnormal bony sites and the contralateral normal sites, and the abnormal-to-normal uptake ratios (A/N ratios) were obtained for both studies. Results: All patients had abnormal findings on 3-phase bone scanning, whereas 17 (71%) had abnormal findings on 99m Tc-HMPAO WBC studies, of which 15 were confirmed to be true-positive. In those 15 patients, the mean A/N ratios for 99m Tc-MDP and 99m Tc-HMPAO WBC were 3.0 6 1.6 (range, 1.3-6.2) and 1.8 6 0.3 (range, 1.4-2.2), respectively. In the other 9 patients, whose scan results were clinically confirmed to be true-negative, the mean A/N ratios for 99m Tc-MDP and 99m Tc-HMPAO WBC were 2.1 6 1.2 and 1.2 6 0.2, respectively. In the group with a 99m Tc-MDP A/N ratio greater than 2 (n 5 15), 87% (13/15) had a high 99m Tc-HMPAO WBC A/N ratio (.1.5), including 2 that were falsepositive. In the remaining 2 patients, one with chronic osteomyelitis and the other with a recent hip prosthesis, 99m Tc-HMPAO WBC ratios were normal. In the group with a bone A/N ratio of less than 2 (n 5 9), only 4 patients (44%) were true-positive for acute osteomyelitis. Conclusion: 99m Tc-MDP bone scanning alone, with an A/N ratio of more than 2, is useful in detecting osteomyelitis in violated bone except in the case of a recent hip prosthesis or chronic osteomyelitis.

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Tc-99m HMPAO Leukocyte and Tc-99m Nanocolloid Scintigraphy in Posttraumatic Bone Infection

Cited by 8 publications

References 13 publications

Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement)

The Value of Quantitative Uptake of 99mTc-MDP and 99mTc-HMPAO White Blood Cells in Detecting Osteomyelitis in Violated Peripheral Bones

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