2010
DOI: 10.2147/rmi.s9458
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Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

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“…It specifically binds to nonspecific cross-reacting antigen 95 (anti-NCA-95) and is labeled with metastable technetium 99 ( 99m Tc-Besilesomab) before its intravenous administration ( Signore et al, 2018 ; Blazeski et al, 2010 ). It binds with high affinity to receptors in neutrophil membranes and migrates with high specificity to areas of infection and inflammation, with a reduction in its activity in the bloodstream and the production of a low background uptake ( Richter et al, 2011 ; Signore et al, 2018 ; Blazeski et al, 2010 ; Gratz et al, 2012 ). Another part of the radiopharmaceutical is freely diffused towards infection sites due to the increase in blood flow ( Richter et al, 2011 ; Meller et al, 2010 ).…”
Section: Introductionmentioning
confidence: 99%
“…It specifically binds to nonspecific cross-reacting antigen 95 (anti-NCA-95) and is labeled with metastable technetium 99 ( 99m Tc-Besilesomab) before its intravenous administration ( Signore et al, 2018 ; Blazeski et al, 2010 ). It binds with high affinity to receptors in neutrophil membranes and migrates with high specificity to areas of infection and inflammation, with a reduction in its activity in the bloodstream and the production of a low background uptake ( Richter et al, 2011 ; Signore et al, 2018 ; Blazeski et al, 2010 ; Gratz et al, 2012 ). Another part of the radiopharmaceutical is freely diffused towards infection sites due to the increase in blood flow ( Richter et al, 2011 ; Meller et al, 2010 ).…”
Section: Introductionmentioning
confidence: 99%