Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Blazeski, Adriana; Kozloff, Kenneth M.; Scott, Peter J. H.

doi:10.2147/rmi.s9458

Cited by 3 publications

(1 citation statement)

References 77 publications

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“…It specifically binds to nonspecific cross-reacting antigen 95 (anti-NCA-95) and is labeled with metastable technetium 99 ( 99m Tc-Besilesomab) before its intravenous administration ( Signore et al, 2018 ; Blazeski et al, 2010 ). It binds with high affinity to receptors in neutrophil membranes and migrates with high specificity to areas of infection and inflammation, with a reduction in its activity in the bloodstream and the production of a low background uptake ( Richter et al, 2011 ; Signore et al, 2018 ; Blazeski et al, 2010 ; Gratz et al, 2012 ). Another part of the radiopharmaceutical is freely diffused towards infection sites due to the increase in blood flow ( Richter et al, 2011 ; Meller et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Semi-quantitative analysis with 99mTc-Besilesomab in musculoskeletal system infections

Guardia-Jimena,

Martínez-Valle Torres,

Arenas Aguaza

et al. 2023

Bone Reports

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Section: Introductionmentioning

confidence: 99%

Semi-quantitative analysis with 99mTc-Besilesomab in musculoskeletal system infections

Guardia-Jimena,

Martínez-Valle Torres,

Arenas Aguaza

et al. 2023

Bone Reports

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Differential diagnosis of diabetic neuroosteoarthropathy and osteomyelitis using medical imaging techniques

Dvoryanchikov,

Tokmakova,

Galstyan

et al. 2024

Endo Serg

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According to modern concepts, Charcot’s neuro-osteoarthropathy (Charcot’s foot) is considered as an aseptic inflammatory process in individuals with distal polyneuropathy, which leads to damage to bones and joints. Most often, Charcot’s foot is formed in patients with diabetes mellitus (DM) and affects the foot and ankle joint. Diabetic neuroosteoarthropathy (DNOAP) is divided into active and inactive stages. The typical clinical picture of the active stage of diabetic neuroosteoarthropathy is edema and hyperemia of the affected foot, with a temperature gradient of more than 2 °C compared with an unaffected foot. The nonspecific clinical picture of the active stage of diabetic neuroosteoarthropathy makes it difficult to diagnose and often leads to the need for differential diagnosis of the active stage of diabetic neuroosteoarthropathy and osteomyelitis, which is one of the most difficult issues in clinical practice. Early detection of these conditions is crucial, since treatment of the active stage of diabetic neuroosteoarthropathy can prevent irreversible deformity of the foot, and detection of osteomyelitis will allow timely antibiotic therapy. Signs of changes in bone and foot structures in the active stage of diabetic neuroosteoarthropathy in images obtained by computer X-ray, magnetic resonance and emission tomography may be similar to signs of osteomyelitis, which determines the importance of choosing an imaging method when examining a patient and developing an effective algorithm for early diagnosis of DNOAP. In this review, the main attention will be paid to the distinctive features of the active stage of diabetic neuroosteoarthropathy and osteomyelitis when using imaging research methods.

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Leukocyte and bacteria imaging in prosthetic joint infection

Glaudemans

Galli

Pacilio

et al. 2013

eCM

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There has been a significant increase in the number of joint prosthesis replacements worldwide. Although relatively uncommon, complications can occur with the most serious being an infection. Various radiological and nuclear imaging techniques are available to diagnose prosthetic joint infections (PJI). In this review article, we describe the pathophysiology of PJI, the principles of nuclear medicine imaging and the differences between Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET). The value of nuclear medicine techniques for clinical practice is also discussed.Then we provide an overview of the most often used radionuclide imaging techniques that may be helpful in diagnosing prosthetic joint infection: the 67 Ga-citrate, labelled white blood cells in vitro and in vivo (monoclonal antibodies directed against specific targets on the leukocytes), and 18 F-fluorodeoxyglucose ( 18 F-FDG). We describe their working methods, the pitfalls, and the interpretation criteria. Furthermore, we review recent advances in imaging bacteria, a molecular imaging method that holds promises for the detection of occult infections. We conclude proposing two diagnostic flow-charts, based on data in the literature, that could help the clinicians to choose the best nuclear imaging method when they have a patient with suspicion of or with proven PJI.

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Besilesomab for imaging inflammation and infection in peripheral bone in adults with suspected osteomyelitis

Cited by 3 publications

References 77 publications

Semi-quantitative analysis with 99mTc-Besilesomab in musculoskeletal system infections

Semi-quantitative analysis with 99mTc-Besilesomab in musculoskeletal system infections

Differential diagnosis of diabetic neuroosteoarthropathy and osteomyelitis using medical imaging techniques

Leukocyte and bacteria imaging in prosthetic joint infection

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