TBP-associated Factors in the PCAF Histone Acetylase Complex

Kotani, Tomohiro; Zhang, X.; Schiltz, R. Louis; Ogryzko, Vasily; Howard, T.; Swanson, Mark J.; Vassilev, Alex; Zhang, H.; Yamauchi, Jun; Howard, Bruce H.; Qin, Jun; Nakatani, Yoshihiro

doi:10.1101/sqb.1998.63.493

Cited by 6 publications

(4 citation statements)

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“…In addition to Gcn5p, subunits of SAGA include several Spt proteins that are believed to bridge SAGA with the TATA-binding protein (TBP), an ATM/PI-3-kinase-related protein (Tra1), Ada proteins and a subset of TBP-associated factors (yTAF II s) [91,92]. Subsequent analyses have shown that PCAF and hGCN5 also function in distinct, but similar complexes, and each complex contains mammalian homologues of yAda, ySpt, yTra1 and yTAF proteins [93,94]. The yeast Esa1 protein also functions in a large, approximately 1 MDa multi-subunit complex containing yTra1 [85], and mammalian CBP/p300 has been shown to be component of RNA polymerase II holoenzyme [95,96].…”

Section: Histone Acetyltransferases and Transcriptional Activationmentioning

confidence: 99%

Chromatin remodeling enzymes: who's on first?

2001

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A central problem in the regulation of eukaryotic gene expression is understanding how gene-specific transcriptional activators orchestrate the recruitment of the myriad proteins that are required for transcription initiation. An emerging view indicates that activators must first target two types of chromatin remodeling enzyme to the promoter region: an ATP-dependent SWI/SNF-like complex and a histone acetyltransferase. These two enzymes appear to act synergistically to establish a local chromatin structure that is permissive for subsequent events. Furthermore, several recent studies indicate that the recruitment of chromatin remodeling enzymes must follow an obligatory, sequential order of events that is determined by either promoter context or cell-cycle position. Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled.

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Section: Histone Acetyltransferases and Transcriptional Activationmentioning

confidence: 99%

Chromatin remodeling enzymes: who's on first?

2001

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“…In yeast, ADA3/NGG1 is found as multisubunit complexes containing three to four additional ADA proteins and different TAFs and Spt (30,31,(33)(34)(35)(36). In mammalian cells, the majority of ADA3/NGG1 protein also seems to be complexed with Spt and TAF or TAF-like factors, making up several types of complexes (37)(38)(39)(40)(41). These complexes are thought to be functional homologs of the yeast ADA complexes (37,39,41).…”

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confidence: 99%

The Role of Transcriptional Corepressor Nif3l1 in Early Stage of Neural Differentiation via Cooperation with Trip15/CSN2

Akiyama

Fujisawa

Tashiro

et al. 2003

Journal of Biological Chemistry

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Mouse Nif3l1 gene is highly conserved from bacteria to human. Even though this gene is expressed throughout embryonic development, its biological function is still obscure. Here, we show that Nif3l1 participates in retinoic acid-primed neural differentiation of P19 embryonic carcinoma cells through cooperation with Trip15/CSN2, a transcriptional corepressor/component of COP9 signalosome. We isolated Nif3l1 cDNA from P19 cell cDNA library by a yeast two-hybrid screening using Trip15/CSN2 as a bait. This interaction was confirmed by a pull-down assay and an epitope-tagged coimmunoprecipitation. Although Nif3l1 was mainly detected in the cytoplasm, the translocation of Nif3l1 into the nuclei was observed in retinoic acid-primed neural differentiation of P19 cells and enhanced by the enforced expression of Trip15/CSN2. Furthermore, enforced expression of sense Nif3l1 RNA, but not antisense RNA, enhanced the neural differentiation of P19 cells accompanying the intense down-regulation of Oct-3/4 mRNA expression and the rapid induction of Mash-1 mRNA expression. Luciferase reporter assay showed that Nif3l1 could act as a transcriptional repressor and synergized the transcriptional repression by Trip15/CSN2. These results indicate that Nif3l1 implicates in neural differentiation through the cooperation with Trip15/CSN2.

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“…TFTC acetylates similar lysine residues to SAGA, and is in fact very similar in structure and subunit composition to mammalian SAGA (Brand et al 1999a,b;Cavusoglu et al 2003). Furthermore, PCAF also associates with multiple TAFs (Kotani et al 1998).…”

Section: The Saga Complex Contains Tbp-associated Factorsmentioning

confidence: 99%

The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole

Soffers

Workman

2020

Genes Dev.

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There are many large protein complexes involved in transcription in a chromatin context. However, recent studies on the SAGA coactivator complex are generating new paradigms for how the components of these complexes function, both independently and in concert. This review highlights the initial discovery of the canonical SAGA complex 23 years ago, our evolving understanding of its modular structure and the relevance of its modular nature for its coactivator function in gene regulation.

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TBP-associated Factors in the PCAF Histone Acetylase Complex

Cited by 6 publications

References 50 publications

Chromatin remodeling enzymes: who's on first?

Chromatin remodeling enzymes: who's on first?

The Role of Transcriptional Corepressor Nif3l1 in Early Stage of Neural Differentiation via Cooperation with Trip15/CSN2

The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole

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