Chromatin remodeling enzymes: who's on first?

Fry, Christopher J.; Peterson, Craig L.

doi:10.1016/s0960-9822(01)00090-2

Cited by 244 publications

(164 citation statements)

References 121 publications

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“…Human BRG1 is approximately 74% identical to human BRM (Khavari et al, 1993), 52% identical to Drosophila BRM and 33% identical to yeast SWI2/ SNF2 (Fry and Peterson, 2001). The mammalian SWI/ SNF complexes contain, in addition to BRM or BRG1, 8-10 subunits, which are referred to as BRM-or BRG1-associated factors or BAFs (Wang et al, 1996a, b).…”

Section: Composition Of the Swi/snf Complexesmentioning

confidence: 99%

The SWI/SNF complex and cancer

2009

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The mammalian SWI/SNF complexes mediate ATPdependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

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Section: Composition Of the Swi/snf Complexesmentioning

confidence: 99%

The SWI/SNF complex and cancer

2009

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“…6,27,28 Based on this premise, we assessed whether the expression pattern of the main chromatin remodeling complexes [27][28][29] could explain the different maturation plasticity of analyzed cell populations. As reported in Figure 5, panel a, five different chromatin regulators belonging to the SWI/SNF ATPase family (SMARCA3, SMARCC1, SMARCE1, CHD4, CHD1L), the HDAC1 deacetylase, the MORF acetyl-transferase, two methyl-lysine binding proteins (HP1, CBX5) and the DNA methyl-transferase 3 B exhibited a downregulated expression in CD14 þ monocyte precursors.…”

Section: Chromatin Remodeling Complexesmentioning

confidence: 99%

Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14− and CD14+ human normal myeloid precursors

et al. 2005

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In spite of their apparently restricted differentiation potentiality, hematopoietic precursors are plastic cells able to transdifferentiate from a maturation lineage to another. To better characterize this differentiation plasticity, we purified CD14À and CD14 þ myeloid precursors generated by 'in vitro' culture of human CD34 þ hematopoietic progenitors. Morphological analysis of the investigated cell populations indicated that, as expected, they consisted of granulocyte and monocyte precursors, respectively. Treatment with differentiation inducers revealed that CD14À cells were bipotent granulo-monocyte precursors, while CD14 þ cells appeared univocally committed to a terminal macrophage maturation. Flow cytometry analysis demonstrated that the conversion of granulocyte precursors to the mono-macrophage maturation lineage occurs through a differentiation transition in which the granulocyte-related myeloperoxidase enzyme and the monocyte-specific CD14 antigen are coexpressed. Expression profiling evidenced that the observed trans-differentiation process was accompanied by a remarkable upregulation of the monocyte-related MafB transcription factor.

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“…Recently, the role of chromatin remodeling and histone modification has been implicated in the activation and repression of many eukaryotic genes (19). Several lines of evidence suggest that before activation, some form of Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322 chromatin remodeling of the MCP-1 gene takes place.…”

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confidence: 99%

Communication Between NF-κB and Sp1 Controls Histone Acetylation Within the Proximal Promoter of the Monocyte Chemoattractant Protein 1 Gene

Boekhoudt

Guo

Beresford

et al. 2003

The Journal of Immunology

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The induction of the monocyte chemoattractant protein 1 gene (MCP-1) by TNF occurs through an NF-κB-dependent distal regulatory region and an Sp1-dependent proximal regulatory region that are separated by 2.2 kb of sequence. To investigate how these regions coordinate activation of MCP-1 in response to TNF, experiments were performed to examine the role of coactivators, changes in local chromatin structure, and the acetylation of histones at the MCP-1 regulatory regions. An E1a-sensitive coactivator was found to be required for expression. In vivo nuclease sensitivity assays identified changes in response to TNF at both the proximal and distal regions that were dependent on the p65 subunit of NF-κB and Sp1. Chromatin immunoprecipitations used to analyze factor assembly and histone acetylation at the distal and proximal regions showed that Sp1 binding to and histone acetylation of the proximal region was dependent on NF-κB p65. Conversely, Sp1 assembly at the proximal region was required for p65 binding to and acetylation of the distal region, suggesting communication between the two regions during gene activation. These data and the NF-κB p65-dependent histone acetylation of a middle region sequence suggest a potential order for the assembly, acetylation and accessibility of the MCP-1 regulatory regions in response to TNF.

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Chromatin remodeling enzymes: who's on first?

Cited by 244 publications

References 121 publications

The SWI/SNF complex and cancer

The SWI/SNF complex and cancer

Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14− and CD14+ human normal myeloid precursors

Communication Between NF-κB and Sp1 Controls Histone Acetylation Within the Proximal Promoter of the Monocyte Chemoattractant Protein 1 Gene

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