TB meets COPD: An emerging global co-morbidity in human lung disease

O'Toole, Ronan; Shukla, Shakti D.; Walters, E. Haydn

doi:10.1016/j.tube.2015.08.005

Cited by 41 publications

(43 citation statements)

References 47 publications

(57 reference statements)

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“…There are, however, limited published data, some from longitudinal studies, suggesting that both relationships exist. [26][27][28][29] However, in spite of these limitations we suggest that our study serves as an important first step towards investigating differ ences between TOPD and more common forms of COPD.…”

Section: Researchmentioning

confidence: 94%

Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

et al. 2017

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Background. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype. Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB. Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (<-950 HU), gas trapping (<-860 HU) and fibrosis (>-200 HU). Findings in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features. Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33) or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Δ=-17.7%; p=0.001) and inspiratory capacity (Δ=-21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Δ=+6.2% (p=0.021), +0.36% (p=0.017) and +3.5% (p=0.098), respectively). Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related COPD and warrant further study.

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Section: Researchmentioning

confidence: 94%

Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

et al. 2017

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“…Despite a remarkable drop in TB incidence over the past century in Western Europe, TB remains a considerable health issue among foreign-born residents and recent immigrants from endemic countries,2 as well as in certain groups of socially marginalised citizens 3 4. In addition to the well-described correlation between HIV infection and TB,5 previous studies have documented a correlation between TB and diabetes,6 7 alcohol abuse,8 smoking9 10 and COPD 11. Previously, an association between TB and lung cancer has also been reported,12 although it may to a large extent represent shared risk factors.…”

Section: Introductionmentioning

confidence: 95%

Comorbidities, mortality and causes of death among patients with tuberculosis in Denmark 1998–2010: a nationwide, register-based case–control study

Fløe

Hilberg

Wejse

et al. 2017

Thorax

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“…There is growing evidence of a bi-directional relationship between TB and chronic obstructive lung disease (COPD) (18). Smoking is a major, well-established risk factor for COPD (1920) and it is also known that smoking increases the risk of TB (2122).…”

Section: Discussionmentioning

confidence: 99%

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

Choi

Lee

et al. 2017

J Korean Med Sci

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Tuberculosis (TB) is associated with an increased risk of chronic lung impairment. The aim of this study was to compare the clinical characteristics and lung functions according to definition of past TB. We used the population-based, Korea National Health and Nutrition Examination Survey (KNHANES) (2008–2012) to analyze 13,522 subjects age 40 years or older who underwent spirometry and chest X-ray (CXR). Subjects with TB lesions on CXR (with or without a history of TB) were older, more likely to be male, ever smokers, and of low socioeconomic status than subjects with only a history of TB or without evidence of TB. Airflow obstruction (AFO) was associated with only a history of TB (odds ratio [OR] 1.53, 95% confidence interval [CI] 0.95–2.46), only TB lesion on CXR (OR 2.37, 95% CI 1.80–3.12), and both a history and TB lesions on CXR (OR 4.47, 95% CI 3.07–6.51) after adjustment for gender, age, body mass index, education, income, and smoking amount (P for trend < 0.001). Spirometric restriction was associated with only a history of TB (OR 1.29, 95% CI 0.80–2.08), only TB lesions on CXR (OR 2.03, 95% CI 1.49–2.76), and both a history and TB lesions on CXR (OR 2.65, 95% CI 1.74–4.05) after adjustment for the above variables (P for trend < 0.001). How to define past TB in population study affects the magnitude of association between past TB and respiratory dysfunction. Without considering TB lesions on CXR, the association between TB and respiratory dysfunction could be underestimated.

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TB meets COPD: An emerging global co-morbidity in human lung disease

Cited by 41 publications

References 47 publications

Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

Comorbidities, mortality and causes of death among patients with tuberculosis in Denmark 1998–2010: a nationwide, register-based case–control study

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

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