Tb-Doped core–shell–shell nanophosphors for enhanced X-ray induced luminescence and sensitization of radiodynamic therapy

Ren, Yufu; Rosch, Justin G.; Landry, Michel; Winter, Hayden; Khan, Syamantak; Pratx, Guillem; Sun, Conroy

doi:10.1039/d0bm00897d

Cited by 16 publications

(21 citation statements)

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“…The first strategy explored was co-doping with a sensitizer ion. The incorporation of sensitizer ions into a nanomaterial represents a facile route to improved luminescence intensity with no additional synthetic steps, thus improving the potential for applications relative to more complex approaches such as dye sensitization or multishell architectures. , …”

Section: Resultsmentioning

confidence: 99%

“…The incorporation of sensitizer ions into a nanomaterial represents a facile route to improved luminescence intensity with no additional synthetic steps, thus improving the potential for applications relative to more complex approaches such as dye sensitization or multishell architectures. 45,46 With respect to Eu 3+ -doped materials, sensitization using Gd 3+ is well established for photoluminescence. Gd 3+ has been demonstrated to sensitize Eu 3+ via quantum cutting through two sequential energy transfer events.…”

Section: Sqmentioning

confidence: 99%

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Investigating the Fundamental Material Properties That Influence the Radioluminescence of Lanthanide-Doped Nanoparticles

et al. 2022

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The rapid development of radioluminescent nanomaterials has left uncertainties in how their properties compare to bulk materials or other luminescent nanoparticles. The effects of material density and effective atomic number, activator concentration, co-doped sensitization, and core/ shell architectures were examined, with a focus on LiLuF 4 nanoparticles doped with Eu 3+ . Varying material density and effective atomic number were found to affect the exciton recombination efficiency and subsequent excitation of activator ions. Given the indirect excitation processes in radioluminescence, we observed that the dependence on dopant concentration is highly specific to the choice of the activator ion and host composition. Strategies to enhance the radioluminescence efficiency were explored through co-doping with a sensitizer ion or core/shell architectures. Demonstrated herein, co-doping is a viable strategy to improve radioluminescence; however, the effect is highly dependent on the sensitizer−activator ion combination, as well as the population efficiency of the sensitizer. Core/shell structures were effective in improving the efficiency of individual activator ions in the lattice; however, the enhancement may not compensate for the addition of nonluminescent shell material. The results provide insight on the development of radioluminescent nanoparticles and their relationship to the properties that govern other luminescence processes.

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Section: Resultsmentioning

confidence: 99%

Section: Sqmentioning

confidence: 99%

Investigating the Fundamental Material Properties That Influence the Radioluminescence of Lanthanide-Doped Nanoparticles

et al. 2022

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“…Under X-ray irradiation, SrAl 2 O 4 :Eu 2+ nanoscintillators emitted visible photons, which subsequently photoactivated merocyanine 540 to generate cytotoxic singlet oxygen ( 1 O 2 ). This X-ray induction method overcame the shallow penetration limitation associated with conventional light sources for PDT. , Scintillating nanoparticles with various compositions, such as SrAl 2 O 4 :Eu 2+ , LaF 3 :Tb/Ce, Tb 2 O 3 , NaGdF 4 :Tb, NaCeF 4 :Gd/Tb, and Gd 2 (WO 4 ) 3 :Tb, have proven effective as X-ray transducers when combined with organic photosensitizers for PDT. − …”

Section: Technological Applicationsmentioning

confidence: 99%

Rare-Earth Doping in Nanostructured Inorganic Materials

et al. 2022

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Impurity doping is a promising method to impart new properties to various materials. Due to their unique optical, magnetic, and electrical properties, rare-earth ions have been extensively explored as active dopants in inorganic crystal lattices since the 18th century. Rare-earth doping can alter the crystallographic phase, morphology, and size, leading to tunable optical responses of doped nanomaterials. Moreover, rare-earth doping can control the ultimate electronic and catalytic performance of doped nanomaterials in a tunable and scalable manner, enabling significant improvements in energy harvesting and conversion. A better understanding of the critical role of rare-earth doping is a prerequisite for the development of an extensive repertoire of functional nanomaterials for practical applications. In this review, we highlight recent advances in rare-earth doping in inorganic nanomaterials and the associated applications in many fields. This review covers the key criteria for rare-earth doping, including basic electronic structures, lattice environments, and doping strategies, as well as fundamental design principles that enhance the electrical, optical, catalytic, and magnetic properties of the material. We also discuss future research directions and challenges in controlling rare-earth doping for new applications.

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“…In addition, the production of ROS utilized its toxicity to damage DNA either via direct ionization or indirect free radicals generation. [ 214 ] The X‐ray‐activated nano scintillators for inner‐bed cancer treatment could generate reactive cytotoxicity species, for example, nitrogen or reactive oxygen, via a heat transformation of X‐ray high energy to low energy photons. Heavy metals, such as tantalum, can generate photoelectrons and auger electrons by irradiating X‐ray waves.…”

Section: Exo‐stimuli‐responsive Nanoparticles (Ex‐srnps) For Smart Dr...mentioning

confidence: 99%

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Zhang

Lin

Lin³

et al. 2021

Advanced Science

137

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Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates and dose-limiting toxicity remain as major dilemmas for immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with immunotherapy offer the possibility to amplify anti-tumor immune responses, where the weak acidity, high concentration of glutathione, overexpressions of enzymes, and reactive oxygen species, and external stimuli in tumors act as triggers for controlled drug release. This review highlights the design of srNPs based on tumor microenvironment and/or external stimuli to combine with different anti-tumor drugs, especially the immunoregulatory agents, which eventually realize synergistic immunotherapy of malignant primary or metastatic tumors and acquire a long-term immune memory to prevent tumor recurrence. The authors hope that this review can provide theoretical guidance for the construction and clinical transformation of smart srNPs for controlled drug delivery in synergistic cancer immunotherapy.

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Tb-Doped core–shell–shell nanophosphors for enhanced X-ray induced luminescence and sensitization of radiodynamic therapy

Abstract: The development of radiation responsive materials, such as nanoscintillators, enables a variety of exciting new theranostic applications. In particular, the ability of nanophosphors to serve as molecular imaging agents in...

Cited by 16 publications

References 58 publications

Investigating the Fundamental Material Properties That Influence the Radioluminescence of Lanthanide-Doped Nanoparticles

Investigating the Fundamental Material Properties That Influence the Radioluminescence of Lanthanide-Doped Nanoparticles

Rare-Earth Doping in Nanostructured Inorganic Materials

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

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