Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF- β 1/Smad pathway

Weng, Hongbo; Han, Wenxue; Xiong, Yanwen; Jin, Zhouhui; Zhang, Lan; Liu, Cheng; Zhang, Xuemei; Peng, Wen

doi:10.1016/s1875-5364(18)30034-7

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…STRING is a database used for analyzing protein-protein associations. GO enrichment analysis can elucidate which GO terms are over-represented or under-represented in the aspect of biological processes, molecular functions, and cellular components 13,14. The obtained potential targets of P. elata were analyzed via GO enrichment analysis, and target-pathway networks were constructed via the STRING database.…”

Section: Discussionmentioning

confidence: 99%

“…The rats were anesthetized using 10% chloral hydrate. The rat model for cerebral ischemia and reperfusion injury was prepared using Longa’s suture method 13. It was established by modified middle cerebral artery occlusion (MCAO).…”

Section: Methodsmentioning

confidence: 99%

“…The neurological status was assessed after the animal was awake and 24 h after the injury according to the Zea-longa scoring system 13. A score of 0 was given to normal animals with no symptoms and no signs of neurological deficit.…”

Section: Methodsmentioning

confidence: 99%

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Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

Niu¹,

Zhang²,

Li³

et al. 2019

DDDT

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ObjectiveThe aim of this study was to identify the active anti-ischemic components of Pterocypsela elata (P. elata) using a network pharmacology approach to construct an effective component anti-cerebral ischemic target network and systematically analyze this medicinal material.MethodsPharmacological studies have shown that P. elata has an obvious effect against cerebral ischemia. To identify the potential targets, 14 components of P. elata were docked to each structural element of the targets in the DRAR-CPI database by reverse docking technology. We then compared the identified potential targets with FDA-approved targets for stroke/cerebral infarction treatment in the DrugBank database and identified the active components of P. elata and their potential targets for stroke/cerebral infarction treatment. The active component-target networks were constructed using Cytoscape 3.5.1 software. The target protein-protein interactions were analyzed using the STRING database. KEGG pathway analysis and gene ontology (GO) enrichment analysis were performed through the Database for Annotation, Visualization and Integrated Discovery (DAVID).ResultsThere were 14 active components identified from P. elata and 21 potential targets identified for cerebral ischemia treatment, including carbonic anhydrase 2, ribosyldihydronicotinamide dehydrogenase, cholinesterase, and glutathione S-transferase P. The main involved pathways include metabolic pathways, complement and coagulation cascades and steroid hormone biosynthesis.ConclusionThrough a network pharmacology approach, we predicted the active components of P. elata and their potential targets for cerebral ischemia treatment. Our results provide new perspectives and clues for further studies on the anti-cerebral ischemia mechanism of P. elata.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

Niu¹,

Zhang²,

Li³

et al. 2019

DDDT

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“…Numerous studies have indicated that TGF-β target regulators such as resveratrol (RSV), Salvia miltiorrhiza, Taxus chinensis, and calcitriol improve fibrosis in DN via complex signaling pathways (Yu et al, 2015;Qiao et al, 2017;Weng et al, 2018;Xiang et al, 2018).…”

Section: The Contribution Of Tgf-β In Dnmentioning

confidence: 99%

An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy

Cao

Zhao

Chen

et al. 2021

Front. Cell Dev. Biol.

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Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by its complex pathogenesis, higher risk of mortality, and the lack of effective diagnosis and treatment methods. Many studies focus on the diagnosis and treatment of diabetes mellitus (DM) and have reported that the pathophysiology of DN is very complex, involving many molecules and abnormal cellular activities. Given the respective pivotal roles of NF-κB, Nrf2, and TGF-β in inflammation, oxidative stress, and fibrosis during DN, we first review the effect of posttranslational modifications on these vital molecules in DN. Then, we describe the relationship between these molecules and related abnormal cellular activities in DN. Finally, we discuss some potential directions for DN treatment and diagnosis. The information reviewed here may be significant in the design of further studies to identify valuable therapeutic targets for DN.

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“…Diabetic nephropathy (DN), one of serious diabetic microvascular complications of diabetes mellitus, is regarded as a dominative cause of end-stage renal disease. 1,2 It was reported that patients with DN could result in end-stage renal failure and disability worldwide with high mortality, affecting approximately 40% of diabetic patients. 3,4 Therefore, DN raised great concern in researchers in this field.…”

Section: Introductionmentioning

confidence: 99%

Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study

Jiang

Zhang

et al. 2021

Clinical Laboratory Analysis

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Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF- β 1/Smad pathway

Cited by 18 publications

References 30 publications

<p>Network pharmacology study on the active components of <em>Pterocypsela elata</em> and the mechanism of their effect against cerebral ischemia</p>

<p>Network pharmacology study on the active components of <em>Pterocypsela elata</em> and the mechanism of their effect against cerebral ischemia</p>

An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy

Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study

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