2019
DOI: 10.3390/pathogens8040205
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Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report

Abstract: Investigation of the microbial community in the female reproductive tract has revealed that the replacement of a community dominated by Lactobacillus with pathogenic bacteria may be associated with implantation failure or early spontaneous abortion in patients undergoing assisted reproductive technology (ART) treatment. Herein we describe taxonomically and functionally the endometrial microbiome of an infertile patient with repeated reproductive failures (involving an ectopic pregnancy and two clinical miscarr… Show more

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Cited by 40 publications
(39 citation statements)
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References 30 publications
(42 reference statements)
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“…(2) the integrity of the epithelial barrier could be impaired; and (3) the microbial-secreted metabolites and the inflammation triggered by TLR activation could lead to suppression and/or overgrowth of specific bacteria [30]. The potential molecular functions of the endometrial microbes were linked to cell metabolism, motility, genetic information, immune system, and signalling processes in the NGS studies [5,20]. Regardless of all these hypotheses, future studies are needed to identify the basal uterine microbiota, its diversity and its functions and interactions with the endometrium.…”
Section: Possible Function Of Microbes In the Uterusmentioning
confidence: 99%
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“…(2) the integrity of the epithelial barrier could be impaired; and (3) the microbial-secreted metabolites and the inflammation triggered by TLR activation could lead to suppression and/or overgrowth of specific bacteria [30]. The potential molecular functions of the endometrial microbes were linked to cell metabolism, motility, genetic information, immune system, and signalling processes in the NGS studies [5,20]. Regardless of all these hypotheses, future studies are needed to identify the basal uterine microbiota, its diversity and its functions and interactions with the endometrium.…”
Section: Possible Function Of Microbes In the Uterusmentioning
confidence: 99%
“…Atopobium [6,[8][9][10], Bacteroides [12], Betaproteobacteria [12], Bifidobacterium [5,[8][9][10][11]13,104], Burkholderia [7], Chitinophagaceae [12], Corynebacterium [104], Escherichia/Shigella [10,12], Flavobacterium [4], Gardnerella [5][6][7][8][9][10][11]13], Lactobacillus [4][5][6][7][8][9][10][11]13,104], Megasphaera [9,10], Pelomonas [12], Prevotella [8][9][10][11]13], Pseudoalteromonas [5], Rhodanobacter [5], Sneathia [8,9], Staphylococcus [8]…”
Section: Healthymentioning
confidence: 99%
See 1 more Smart Citation
“…Aside from the assessment of the embryo´s mutational/chromosomal status, additional genetic tests assessing fertility, based on high-throughput techniques such as NGS, are beyond the scope of an ordinary clinical practice to increase the reproductive chances of a couple, i.e., endometrial receptivity analysis and more recently, endometrial microbiome test [ 14 , 15 ].…”
Section: The Reproductive Journeymentioning
confidence: 99%
“…Prenatal screening is the risk estimation of fetal aneuploidies based on high-resolution ultrasound scans, in order to assess ultrasonographic markers including nuchal translucency, combined with biochemical determinations in maternal blood samples of free beta-subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in the first trimester, and the alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (βhCG) in the second trimester [ 15 ]. If this risk of congenital defect is high, invasive procedures such as chorionic villus sampling (CVS) or amniocentesis are recommended [ 16 ].…”
Section: The Reproductive Journeymentioning
confidence: 99%