Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways

Das, Joydeep; Ghosh, Jyotirmoy; Manna, Prasenjit; Sinha, Mahua; Sil, Parames C.

doi:10.1016/j.toxlet.2009.03.001

Cited by 188 publications

(113 citation statements)

References 48 publications

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“…(32)(33)(34). Moreover, there have been reports showing that taurine was capable of suppressing apoptosis through the mitochondrial pathway in retinal ganglion cells (35), hepatocytes (36), and testicular tissue (37). In the present study, with taurine treatment, the serum deprivation-induced release of cytochrome c from the mitochondria was reduced Figure 5.…”

Section: Discussionsupporting

confidence: 52%

Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Zhang¹,

Zhou²,

Chen³

et al. 2011

Braz J Med Biol Res

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Taurine has positive effects on bone metabolism. However, the effects of taurine on osteoblast apoptosis in vitro have not been reported. The aim of this study was to investigate the activity of taurine on apoptosis of mouse osteoblastic MC3T3-E1 cells. The data showed that 1, 5, 10, or 20 mM taurine resulted in 16.7, 34.2, 66.9, or 63.75% reduction of MC3T3-E1 cell apoptosis induced by the serum deprivation (serum-free α-MEM), respectively. Taurine (1, 5, or 10 mM) also reduced cytochrome c release and inhibited activation of caspase-3 and -9, which were measured using fluorogenic substrates for caspase-3/caspase-9, in serum-deprived MC3T3-E1 cells. Furthermore, taurine (10 mM) induced extracellular signal-regulated kinase (ERK) phosphorylation in MC3T3-E1 cells. Knockdown of the taurine transporter (TAUT) or treatment with the ERK-specific inhibitor PD98059 (10 μM) blocked the activation of ERK induced by taurine (10 mM) and abolished the anti-apoptotic effect of taurine (10 mM) in MC3T3-E1 cells. The present results demonstrate for the first time that taurine inhibits serum deprivation-induced osteoblast apoptosis via the TAUT/ERK signaling pathway

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Section: Discussionsupporting

confidence: 52%

Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Zhang¹,

Zhou²,

Chen³

et al. 2011

Braz J Med Biol Res

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“…The exact mechanism by which arsenic exerts its toxic effect is not clear. Indeed, some studies suggest that As III exert its toxicity by generating reactive oxygen species (ROS) and thereby oxidative stress (Chang et al, 2007) and ultimately apoptosis (Das et al, 2009;Prakash et al, 2011;Khan et al, 2013;Kumar et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Concurrent Administration of Curcumin Mitigates Arsenic - and Chlorpyrifos - induced Apoptosis in Rat Thymocytes

Prakash¹

2014

Adv. Anim. Vet. Sci.

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The present study was undertaken to evaluate the arsenic and chlorpyrifos-induced apoptosis alone or in combination. In addition, the ameliorative efficacy of curcumin on as and/or chlorpyrifos-induced apoptosis in rat thymocytes in vivo. Adult male Wistar rats weighing 80-100g were divided into nine groups containing seven animals in each. The rats were fed with arsenic (20 ppm) in drinking water, chlorpyrifos (5 mg/kg body wt.), curcumin (100 mg/kg body wt.) and their combination for 28 days. After 28 days of exposure period, animals were sacrificed with cervical dislocation and thymus was collected to harvest the thymocytes and further reactive oxygen species (ROS) generation (by using non fluorescent DCFH-DA), % apoptotic DNA (by using propidium iodide) and mitochondrial transmembrane potential (by using DiOC 6 ) were evaluated using Becton Dickenson Flowcytometer. The results showed that, the chlorpyrifos-induced per cent apoptotic DNA content (15.75±1.38), cells with loss of ψ Δm (16.70±1.33) and ROS generation (23.93±1.18) were significantly higher than the arsenic alone (10.95±1.05), (13.75±1.44) and (21.86±0.84) respectively, at given doses due to increased production of ROS. Arsenic and chlorpyrifos in combination potentiated the induction of apoptosis than their alone effect, however concurrent administration of curcumin considerably inhibited the induction of apoptosis by scavenging free radicals.All copyrights reserved to Nexus® academic publishers

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“…However, the mechanism(s) by which arsenic impairs male reproductive function remains unclear. Emerging evidence from the literature supports the role of free radical and reactive oxygen species (ROS) mediated oxidative stress in the pathophysiology of As-mediated organ injury and cell death (Das et al 2009). Very little is, however, known about the use of antioxidants as the possible preventive or curative agents that can be targeted as therapeutic tools in testicular abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…The repeated use of arsenic is as herbicides, insecticides, rodenticides and food preservatives (Mehranjani and Hemadi 2007). Though adverse, on the other hand, reality relics that a large number of populations in some areas of the world are drinking arsenic-contaminated ground water and the number of cases torment from As-induced organ dysfunctions are increasing terrifically (Das et al 2009). Arsenic is a major environmental chemical and a known reproductive toxicant via the depression of spermatogenesis and androgenesis in males (Morakinyo et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In the testes enhanced production of ROS causes significant alteration in tissue physiology, spermatogenic process or induces oxidative damage to DNA, which is potential risk to offspring (Sharma and Kumar 2011). At the same time, renewed attention has been created due to the therapeutic application of arsenic in the treatment of lymphoid and hemopoietic neoplasms such as acute promyelocytic leukemia (Das et al 2009). Arsenic has been found to impair male reproductive function like spermatogenesis and testosterone release, inhibited testicular enzyme function, and reduced the weight of the male sex organs (Sarkar et al 1991) probably by inducing oxidative stress (Chang et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Diallyl trisulfide (DATS) abrogates arsenic induced testicular oxidative stress in rats

Prabu

Sumedha

2014

International Journal of Pharmacology and Toxicology

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Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways

Cited by 188 publications

References 48 publications

Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine transporter/ERK signaling pathway

Concurrent Administration of Curcumin Mitigates Arsenic - and Chlorpyrifos - induced Apoptosis in Rat Thymocytes

Diallyl trisulfide (DATS) abrogates arsenic induced testicular oxidative stress in rats

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