Taurine promotes B‐cell activation by interaction with the V_H/V_L framework regions of B‐cell receptor

Abstract

Taurine (Tau) is a special sulphur-containing amino acid and has been widely used as a dietary supplement. Although Tau exists in lymphocytes in large quantities, the physiological significance of Tau to modulate human immunity is unknown. In the present study, we first found that Tau regulates the B-cell receptor (BCR)-mediated signal transduction and induces the B cells activation. The IgG production of mice after ovalbumin immunization was also increased by Tau administration. Moreover, the isothermal titration calorimetry and surface plasmon resonance analysis have shown that Tau specifically bound to the IgG2a-BCR. The Tau could bind to IgG F(ab 0 ) 2 regions via fluorescence spectroscopy analysis. In the molecular docking analysis, Tau bound to the framework regions (FRs) of variable region of the heavy chains (V H ) and in the light chains (V L ) of IgG2a-BCR. Our results suggested that Tau could improve the activation of B cells by interaction with the V H /V L FRs of BCR.

Taurine Alleviates Experimental Colitis by Enhancing Intestinal Barrier Function and Inhibiting Inflammatory Response through TLR4/NF-κB Signaling

“…The impaired intestinal epithelial barrier can result in increased intestinal permeability, consequently exposing the host to pathogens and eliciting inflammatory responses. Taurine has the ability to affect the function of various immune cells, including T regulatory cells, B cells, macrophages, and neutrophils, thereby regulating immune responses. , Research demonstrated that taurine may play a preventive role in colitis by inhibiting the expression of macrophage inflammatory protein 2, which could reduce neutrophil infiltration and subsequent tissue damage. , In a mouse model of AOM/DSS-induced colon cancer, taurine exhibited anticarcinogenic effects, suggesting its therapeutic potential against colon cancer . In the present study, we explored the impact of taurine deficiency on the development of UC.…”

“…Taurine has the ability to affect the function of various immune cells, including T regulatory cells, B cells, macrophages, and neutrophils, thereby regulating immune responses. 60,61 Research demonstrated that taurine may play a preventive role in colitis by inhibiting the expression of macrophage inflammatory protein 2, which could reduce neutrophil infiltration and subsequent tissue damage. 30,31 In a mouse model of AOM/DSS-induced colon cancer, taurine exhibited anticarcinogenic effects, suggesting its therapeutic potential against colon cancer.…”