Taurine Alleviates Experimental Colitis by Enhancing Intestinal Barrier Function and Inhibiting Inflammatory Response through TLR4/NF-κB Signaling
Jiaming Zheng,
Jinglin Zhang,
Yewen Zhou
et al.
Abstract:Taurine (Tau) is a semiessential amino acid in mammals
with preventive
and therapeutic effects on several intestinal disorders. However,
the exact function of taurine in ulcerative colitis (UC) is still
largely unclear. In this study, we used two taurine-deficient mouse
models (CSAD–/– and TauT–/– mice) to explore the influence of taurine on the progression of
UC in both dextran sulfate sodium (DSS)-induced colitis and LPS-stimulated
Caco-2 cells. We found that cysteine sulfinic acid decarboxylase (CSAD)
and t… Show more
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