Taurine‐induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation

Cappelli, Ana Paula Gameiro; Zoppi, Cláudio C.; Barbosa-Sampaio, Helena Cristina; Costa, J. Pinto da; Protzek, André Otávio Peres; Morato, Priscila Neder; Boschero, Antônio Carlos; Carneiro, Everardo M.

doi:10.1111/liv.12291

Cited by 28 publications

(30 citation statements)

References 42 publications

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“…In our study, rats fed a LP diet showed lower body weight and similar biochemical parameters as in several other studies [7,8,54,55], demonstrating that these rats were a suitable model. Although insulinemia was reduced, glycemia was unchanged in rats fed either a LP or NP diet.…”

Section: Discussionsupporting

confidence: 82%

Low-protein diet disrupts the crosstalk between the PKA and PKC signaling pathways in isolated pancreatic islets

Lippo

Batista

Rezende

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Discussionsupporting

confidence: 82%

Low-protein diet disrupts the crosstalk between the PKA and PKC signaling pathways in isolated pancreatic islets

Lippo

Batista

Rezende

et al. 2015

The Journal of Nutritional Biochemistry

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“…Tau also reduced superoxide production in the mitochondria of cardiomyocytes by enhancing electron transport chain activity (Jong et al 2012). Protein-restricted mice supplemented with Tau showed better redox balance and a reduction in ER stress markers such as p-PERK and BIP (Batista et al 2013a, b;Cappelli et al 2013). In accordance with all these studies, we herein report that Tau supplementation decreased the fold change in genes related to the unfolded protein response, apoptosis, and the ER stress pathway in the hypothalamus of the RHT and CHT mice (Tables 5, 6), which may contribute to better leptin signaling in these groups.…”

Section: Discussionmentioning

confidence: 98%

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

et al. 2015

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Malnutrition programs the neuroendocrine axis by disruption of food-intake control, leading to obesity. Taurine (Tau) is neuroprotective and improves anorexigenic actions in the hypothalamus. We evaluated the hypothalamic gene-expression profile and food-intake control in protein-restricted mice submitted to a high-fat diet (HFD) and Tau supplementation. Mice were fed on a control (14 % protein-C) or a protein-restricted diet (6 % protein-R) for 6 weeks. Thereafter, mice received, or not, HFD for 8 weeks (CH and RH) with or without 5 % Tau supplementation (CHT and RHT). Protein restriction led to higher food intake, but calories were matched to controls. Excessive calorie intake occurred in HFD mice and this was prevented by Tau supplementation only in the CH group. Additionally, RH and CH mice developed hypothalamic leptin resistance, which was prevented by Tau. Global alterations in the expressions of genes involved in hypothalamic metabolism, cellular defense, apoptosis and endoplasmic reticulum stress pathways were induced by dietary manipulations and Tau treatment. The orexigenic peptides NPY and AgRP were increased by protein restriction and lowered by the HFD. The anorexigenic peptide Pomc was increased by HFD, and this was prevented by Tau only in CH mice. Thus, food intake was disrupted by dietary protein restriction and obesity. HFD-induced alterations were not enhanced by previous protein deficiency, but the some beneficial effects of Tau supplementation upon food intake were blunted by protein restriction. Tau effects upon feeding behavior control are complex and involve interactions with a vast gene network, preventing hypothalamic leptin resistance.

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“…Recent studies from our group have demonstrated that Tau supplementation in obese mice induced by an HFD improves glucose tolerance and insulin sensitivity, which are impaired by obesity Camargo et al 2013 ;Cappelli et al 2014 ;Vettorazzi et al 2014 ). This improvement can be explained by a decrease in insulin hypersecretion (Vettorazzi et al 2014 ;Ribeiro et al 2012 ) and an increase in hepatic and muscle AKT phosphorylation Ribeiro et al 2012 ) seen in obese mice fed a HFD.…”

Section: Discussionmentioning

confidence: 79%

The Effect of Taurine Supplementation on Glucose Homeostasis: The Role of Insulin-Degrading Enzyme

et al. 2015

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Taurine‐induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation

Abstract: Our data provide evidence for an association between TAU-induced improved glycaemic control because of PTEN inactivation and higher AKT phosphorylation. These effects seem to be related with altered hepatic redox balance in obese mice, and this effect is impaired by protein malnutrition.

Cited by 28 publications

References 42 publications

Low-protein diet disrupts the crosstalk between the PKA and PKC signaling pathways in isolated pancreatic islets

Low-protein diet disrupts the crosstalk between the PKA and PKC signaling pathways in isolated pancreatic islets

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

The Effect of Taurine Supplementation on Glucose Homeostasis: The Role of Insulin-Degrading Enzyme

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